Phenobarbital versus valproate for generalized convulsive status epilepticus in adults. An updated systematic review and meta-analysis [0.03%]
苯巴比妥与丙戊酸治疗成人全身强直阵挛性癫痫持续状态的系统评价和Meta分析
Umair Ul Haq,Neha Majeed,Nisha Kumari et al.
Umair Ul Haq et al.
Ganaxolone in Epilepsy: Insights into a Neurosteroid-Based Therapy [0.03%]
ganaxolone在癫痫治疗中的应用——基于神经甾体的治疗方法新见解
Giovanni Battista Dell&#x;Isola,Margherita Siciliano,Gianluca D&#x;Onofrio et al.
Giovanni Battista Dell&#x;Isola et al.
Neurological and neuropsychiatric disorders, particularly drug-resistant epilepsies and rare genetic syndromes such as CDKL5 deficiency disorder, pose significant therapeutic challenges. Ganaxolone (GNX), a synthetic neurosteroid and positi...
CREB3L4 upregulates SIRT4 expression to increase GABA/glutamate ratio and mitochondrial homeostasis for epilepsy suppression [0.03%]
CREB3L4通过上调SIRT4表达增加GABA/谷氨酸比率和线粒体稳态以抑制癫痫发作
Haoyu Liu,Qiannan Song,Jiayi Jin et al.
Haoyu Liu et al.
Background: cAMP response element-binding protein 3-like transcription factor 4 (CREB3L4) serves as an important transcriptional regulatory factor and plays a crucial role in neurological diseases, however, its specific m...
Standardization of preclinical methodologies for discovery and validation of circulating microRNA biomarkers for post-traumatic epileptogenesis - Lessons learned from the EpiBioS4Rx Project 1 [0.03%]
EpiBioS4Rx项目中用于发现和验证创伤后癫痫发生循环微小核糖核酸生物标志物的临床前方法标准化的经验教训
Noora Puhakka,Mette Heiskanen,Xavier Ekolle Ndode-Ekane et al.
Noora Puhakka et al.
Objective: To analyze the success of harmonization and standardization of plasma miRNA biomarker discovery and validation for post-traumatic epilepsy (PTE) in the EpiBioS4Rx international multicenter project. ...
Bridging surface and depth: A systematic review of seizure patterns in simultaneous scalp and stereo-EEG [0.03%]
连接头皮和深度：同时进行头皮和立体脑电图的癫痫发作模式系统回顾
Cristiana Santos,Daniel Filipe Borges,Joana Isabel Soares
Cristiana Santos
Background: Drug-resistant epilepsy often requires invasive monitoring. Although simultaneous scalp EEG and stereo EEG are increasingly used together, their added value for preoperative evaluation and surgical planning re...
Dynamic functional connectivity variability in the thalamocortical circuit: Insights from Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTs) [0.03%]
丘脑皮层环路中的动态功能连接变化性：来自中央中颞棘波自限性癫痫（SeLECT）的见解
Ahmed Ameen Fateh,Abla Smahi,Muhammad Hassan et al.
Ahmed Ameen Fateh et al.
Background: Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTs) is a dominant childhood epilepsy form characterized by seizures originating from the brain's centrotemporal region. Crucially, unlocking the neural dy...
Aditi Goyal,Shilpa Rao,Mariamma Philip et al.
Aditi Goyal et al.
Background: Focal cortical dysplasia (FCD) is a common cause of focal epilepsy, however pathophysiology of epileptogenesis in FCD remains unresolved. Emerging evidence suggests that dysfunctional astrocytes are key player...
Periodic limb movements among persons with epilepsy: A retrospective polysomnographic study [0.03%]
癫痫患者的周期性四肢运动障碍：一项回顾性的多导睡眠图研究
Manav Jain,Laurel Charlesworth,Helen Driver et al.
Manav Jain et al.
Introduction: Persons with epilepsy (PWE) frequently contend with disrupted sleep related to multiple seizure related as well as other factors like medications and comorbidities. Such disturbances often lead to fragmented...
Clinical and EEG characteristics of sleep-related hypermotor epilepsy in children [0.03%]
儿童睡眠相关过度运动性癫痫的临床和脑电图特征
Xinru Tan,Hailang Liu,Yan Li et al.
Xinru Tan et al.
Background: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy with nocturnal hypermotor seizures. Although SHE was redefined in 2014, comprehensive pediatric studies are still lacking for this disorder. To addre...