Xenopus slc7a5 is essential for notochord function and eye development [0.03%]
Slc7a5对非洲爪蟾脊索功能及眼发育至关重要
Tomohisa Katada,Hiroyuki Sakurai
Tomohisa Katada
slc7a5 (also known as LAT1), largely accepted as an amino acid transporter, has been shown to play important roles in cancer and developmental processes. Because knockout mice of Slc7a5 are embryonically lethal due to placental defects, it ...
Juan R Riesgo-Escovar,Roberto Mayor,Pablo Wappner et al.
Juan R Riesgo-Escovar et al.
MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin [0.03%]
miR-203a在乳腺干细胞分枝形态发生和上皮间充质转化过程中差异表达并抑制过氧化物酶体生成蛋白PERP的表达
Eirikur Briem,Zuzana Budkova,Anna Karen Sigurdardottir et al.
Eirikur Briem et al.
MicroRNAs regulate developmental events such as branching morphogenesis, epithelial to mesenchymal transition (EMT) and its reverse process mesenchymal to epithelial transition (MET). In this study, we performed small RNA sequencing of a br...
Znfl1s are essential for patterning the anterior-posterior axis of zebrafish posterior hindbrain by acting as direct target genes of retinoic acid [0.03%]
咽部尾端 Hindbrain Rhombomere 的模式形成需要 Znfl1 基因直接响应视黄酸的作用
Jingyun Li,Yingmin Zhao,Luqingqing He et al.
Jingyun Li et al.
RA (retinoic acid) signaling is essential for the patterning the hindbrain of vertebrates. Although hundreds of potential RA targets genes are identified, the ones other than hox genes playing roles in patterning anterior-posterior axis of ...
γ-Tubulin small complex formation is essential for early zebrafish embryogenesis [0.03%]
γ-微管蛋白小亚基的形成对斑马鱼早期胚胎发育至关重要
Luis Pouchucq,Cristian A Undurraga,Ricardo Fuentes et al.
Luis Pouchucq et al.
The centrosomal protein γ-tubulin is part of the cytoplasmic γ-tubulin small (γ-TuSCs) and large complexes (γ-TuRCs). Both, molecular and cellular evidence indicate that γ-tubulin plays a central role in microtubule nucleation and mito...
David Muñoz,Héctor Castillo,Juan Pablo Henríquez et al.
David Muñoz et al.
The main purpose of regenerative biology is to improve human health by exploiting cellular and molecular mechanisms favoring tissue repair. In recent years, non-mammalian vertebrates have emerged as powerful model organisms to tackle the pr...
Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats [0.03%]
囊性纤维化大鼠的输精管和附睾丢失非阻塞性输精管和附睾丢失在囊性纤维化大鼠中的作用
Z E Plyler,S E Birket,B D Schultz et al.
Z E Plyler et al.
This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (meso...
Cochlear connexin 30 homomeric and heteromeric channels exhibit distinct assembly mechanisms [0.03%]
cochlera(connexin 30同源和异源通道表现出不同的装配机制)
Jean Defourny,Nicolas Thelen,Marc Thiry
Jean Defourny
Many of the mutations in GJB2 and GJB6, which encode connexins 26 and 30 (Cx26 and Cx30), impair the formation of membrane channels and cause autosomal syndromic and non-syndromic hearing loss. In cochlear non-sensory supporting cells, Cx26...
Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals [0.03%]
突触蛋白4(Cog4)对于前庭神经发育中半规管上皮外伸和延伸的必要性
Aurélie Clément,Bernardo Blanco-Sánchez,Judy L Peirce et al.
Aurélie Clément et al.
The semicircular canals in the inner ear sense angular acceleration. In zebrafish, the semicircular canals develop from epithelial projections that grow toward each other and fuse to form pillars. The growth of the epithelial projections is...
Jitterbug/Filamin and Myosin-II form a complex in tendon cells required to maintain epithelial shape and polarity during musculoskeletal system development [0.03%]
肌腱细胞中的Jitterbug/Filamin和Myosin-II复合体在肌肉骨骼系统发育过程中维持上皮形状和极性所必需
Catalina Manieu,Gonzalo H Olivares,Franco Vega-Macaya et al.
Catalina Manieu et al.
During musculoskeletal system development, mechanical tension is generated between muscles and tendon-cells. This tension is required for muscle differentiation and is counterbalanced by tendon-cells avoiding tissue deformation. Both, Jbug/...