Cochlear stem/progenitor cells from a postnatal cochlea respond to Jagged1 and demonstrate that notch signaling promotes sphere formation and sensory potential [0.03%]
耳蜗干细胞/前体细胞响应JAGGED1信号并表现出 notch 信号促进球形上清的形成和感觉潜能
Etienne Savary,Jean Charles Sabourin,Julien Santo et al.
Etienne Savary et al.
Hair cells and supporting cells of the mammalian cochlea terminally differentiate during development. Recent in vitro evidence suggests the presence of hair cell progenitors in the postnatal cochlea. Phenotypic properties of these cells and...
Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species [0.03%]
RET异构体功能和标志基因在肠神经系统中的表达在不同种类的脊椎动物中是保守的
Tiffany A Heanue,Vassilis Pachnis
Tiffany A Heanue
The enteric nervous system (ENS) derives from migratory neural crest cells that colonize the developing gut tube, giving rise to an integrated network of neurons and glial cells, which together regulate important aspects of gut function, in...
Pofut1 is required for the proper localization of the Notch receptor during mouse development [0.03%]
Pofut1的表达对于子鼠发育过程中Notch受体的正常定位是必需的
Yoshiaki Okamura,Yumiko Saga
Yoshiaki Okamura
Protein O-fucosyltransferase 1 (Pofut1), which catalyzes the addition of O-linked fucose to the EGF domains of the Notch receptor, is indispensable for Notch signaling activation. However, the mechanism of action of Pofut1 in mice is still ...
Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development [0.03%]
刺猬信号和Dpp信号在果蝇眼发育形态发生缝期诱导Cadherin Cad86C的表达
Karin Schlichting,Christian Dahmann
Karin Schlichting
During Drosophila eye development, cell differentiation is preceded by the formation of a morphogenetic furrow, which progresses across the epithelium from posterior to anterior. Cells within the morphogenetic furrow are apically constricte...
The hangover gene negatively regulates bouton addition at the Drosophila neuromuscular junction [0.03%]
晕醉基因通过抑制突触 bouton 的形成负调控果蝇神经肌肉接头的可塑性
Isabel Schwenkert,Rouven Eltrop,Natalja Funk et al.
Isabel Schwenkert et al.
The synaptic growth of neurons during the development and adult life of an animal is a very dynamic and highly regulated process. During larval development in Drosophila new boutons and branches are added at the glutamatergic neuromuscular ...
Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice [0.03%]
SHOX2缺失导致小鼠颞下颌关节发育不良和强直
Shuping Gu,Na Wei,Ling Yu et al.
Shuping Gu et al.
The temporomandibular joint (TMJ) is a unique synovial joint whose development differs from the formation of other synovial joints. Mutations have been associated with the developmental defects of the TMJ only in a few genes. In this study,...
Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo [0.03%]
蛋白酶体缺失时观察到秀丽隐杆线虫胚胎细胞特异性分裂轴的对称重组
Yuki Sugiyama,Asuka Nishimura,Shigeo Ohno
Yuki Sugiyama
A fertilised Caenorhabditis elegans embryo shows an invariable pattern of cell division and forms a multicellular body where each cell locates to a defined position. Mitotic spindle orientation is determined by several preceding events incl...
Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo [0.03%]
小鼠胚胎内胚层祖细胞的区域化及肠孔的发生学发育规律
Vanessa Franklin,Poh Lynn Khoo,Heidi Bildsoe et al.
Vanessa Franklin et al.
This fate-mapping study reveals that the progenitors of all major parts of the embryonic gut are already present in endoderm of the early-head-fold to early-somite stage (1-9 somites) mouse embryo. The anterior endoderm contributes primaril...
A functional screen for genes involved in Xenopus pronephros development [0.03%]
美洲牛蛙前肾发育相关基因的功能筛选研究
Jun-ichi Kyuno,Karine Massé,Elizabeth A Jones
Jun-ichi Kyuno
In Xenopus, the pronephros is the functional larval kidney and consists of two identifiable components; the glomus, the pronephric tubules, which can be divided into four separate segments, based on marker gene expression. The simplicity of...
Comparative Study
Mechanisms of development. 2008 Jul;125(7):571-86. DOI:10.1016/j.mod.2008.03.001 2008
bHLH-PAS family transcription factor methoprene-tolerant plays a key role in JH action in preventing the premature development of adult structures during larval-pupal metamorphosis [0.03%]
甲基 fene 耐受蛋白（molting hormone 作用的效应因子）通过阻止幼虫-蛹变态期成虫结构过早形成而发挥关键作用
R Parthasarathy,Anjiang Tan,Subba R Palli
R Parthasarathy
The biological actions of juvenile hormones are well studied; they regulate almost all aspects of an insect's life. However, the molecular actions of these hormones are not well understood. Recent studies in the red flour beetle, Tribolium ...