The discovery of the fundamental role of VEGF in the development of the vascular system [0.03%]
血管生成素在血管发育中的作用的发现
Domenico Ribatti
Domenico Ribatti
In the 1980', vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) was identified and shown to be a key regulator of endothelial cell proliferation and migration, and vascular permeability. The essenti...
Michelle Kanther,Alexandra Scalici,Azman Rashid et al.
Michelle Kanther et al.
The zebrafish offers powerful advantages as a model system for examining the growth of the skull vault and the formation of cranial sutures. The zebrafish is well suited for large-scale genetic screens, available in large numbers, and conti...
The Hedgehog receptor Patched1 regulates proliferation, neurogenesis, and axon guidance in the embryonic spinal cord [0.03%]
刺猬基因受体Patched1调节胚胎脊髓的增殖、神经发生和轴突导向
Angelo Iulianella,Danielle Stanton-Turcotte
Angelo Iulianella
The formation of the vertebrate nervous system depends on the complex interplay of morphogen signaling pathways and cell cycle progression to establish distinct cell fates. The Sonic hedgehog (Shh) signaling pathway is well understood to pr...
In vivo assessment of gonad status, secondary sex characteristics and spawning in transparent Casper zebrafish [0.03%]
透明Casper斑马鱼体内性腺状态、第二性征和产卵的评估
Nikki Brantley,Charles A Lessman
Nikki Brantley
Important aspects of vertebrate reproduction, such as gametogenesis, involve changes in organs found deep internally and thus not easily studied directly in most living vertebrates due to obscuring pigment and overlying tissues. Transparent...
An in vitro model of region-specific rib formation in chick axial skeleton: Intercellular interaction between somite and lateral plate cells [0.03%]
鸡轴向骨架区段特异性肋骨形成的体外模型：节片细胞与侧板细胞间的细胞间相互作用
Kaoru Matsutani,Koji Ikegami,Hirohiko Aoyama
Kaoru Matsutani
The axial skeleton is divided into different regions based on its morphological features. In particular, in birds and mammals, ribs are present only in the thoracic region. The axial skeleton is derived from a series of somites. In the thor...
EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions [0.03%]
EGL-38/Pax在Caenorhabditis elegans产卵系统中通过EGF通路依赖和非依赖功能协调发育过程
Allison M Webb Chasser,Ryan W Johnson,Helen M Chamberlin
Allison M Webb Chasser
Paired box (Pax) proteins function as regulators of coordinated development in organogenesis by controlling factors such as cell growth and differentiation necessary to organize multiple cell types into a single, cohesive organ. Previous wo...
EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions [0.03%]
EGL-38/Pax通过EGF通路依赖和非依赖功能调节杆形秀丽隐杆线虫产卵系统发育
Allison M Webb Chasser,Ryan W Johnson,Helen M Chamberlin
Allison M Webb Chasser
Paired box (Pax) proteins function as regulators of coordinated development in organogenesis by controlling factors such as cell growth and differentiation necessary to organize multiple cell types into a single, cohesive organ. Previous wo...
Long-label-retaining mammary epithelial cells are created early in ductal development and distributed throughout the branching ducts [0.03%]
长标签保留乳腺上皮细胞在导管发育早期形成并分布在分支导管中
Lauren E Ragle,Robert D Bruno,Corinne A Boulanger et al.
Lauren E Ragle et al.
Long-label retention has been used by many to prove Cairns' immortal strand hypothesis and to identify potential stem cells. Here, we describe two strategies using 5-ethynl-2'-deoxyuridine (EdU) to identify and understand the distribution o...
Use of in vitro electroporation and slice culture for gene function analysis in the mouse embryonic spinal cord [0.03%]
体内电转染和组织切片培养在小鼠胚胎脊髓基因功能分析中的应用
Shuanqing Li,Yunxiao Li,Han Li et al.
Shuanqing Li et al.
The spinal cord is an important part of the central nervous system (CNS). At present, the expression of the exogenous gene in the spinal cord of the embryonic mouse needs in utero spinal cord electroporation, but the success rate of this te...
Nicole Le Douarin and the use of quail-chick chimeras to study the developmental fate of neural crest and hematopoietic cells [0.03%]
Nicole Le Douarin及她利用拟鸡-小鸡嵌合体研究神经嵴和造血细胞的发育命运的工作
Domenico Ribatti
Domenico Ribatti
The quail-chick chimera marking system, devised in 1969, gave a new impetus to the analysis of cell migrations and interactions in the developing nervous, immune and hematopoietic systems. The method is based on the observation that the con...