Rb family-independent activating E2F increases genome stability, promotes homologous recombination, and decreases non-homologous end joining [0.03%]
Rb家族独立激活的E2F可增加基因组稳定性、促进同源重组并减少非同源末端连接
Xun Pei,Elbert Du,Zhentao Sheng et al.
Xun Pei et al.
The retinoblastoma protein Rb is a prototype tumor suppressor inactivated in a variety of cancers. In addition to deregulated cell proliferation, Rb inactivation also causes genome instability that contributes to tumorigenesis. Although the...
Simulations of sea urchin early development delineate the role of oriented cell division in the morula-to-blastula transition [0.03%]
海胆早期发育的模拟界定了定向细胞分裂在囊胚向原肠胚过渡中的作用
Lawrence Bodenstein
Lawrence Bodenstein
The sea urchin morula to blastula transition has long been thought to require oriented cell divisions and blastomere adherence to the enveloping hyaline layer. In a computer simulation model, cell divisions constrained by a surface plane di...
Charles A Ettensohn
Charles A Ettensohn
The cell behaviors associated with gastrulation in sea urchins have been well described. More recently, considerable progress has been made in elucidating gene regulatory networks (GRNs) that underlie the specification of early embryonic te...
Zebrafish Pax1a and Pax1b are required for pharyngeal pouch morphogenesis and ceratobranchial cartilage development [0.03%]
咽袋形态发生和鳃弓软骨发育需要斑马鱼Pax1a和Pax1b基因
Yu-Hsiu Liu,Tz-Chi Lin,Sheng-Ping L Hwang
Yu-Hsiu Liu
Pharyngeal arches are derived from all three germ layers and molecular interactions among the tissue types are required for proper development of subsequent pharyngeal cartilages; however, the mechanisms underlying this process are not full...
Disconnect between the developing eye and craniofacial prominences in the avian embryo [0.03%]
鸟类胚胎眼睛与颅面隆起之间的分离现象
Jamil Jomaa,Jessica Martínez-Vargas,Shadya Essaili et al.
Jamil Jomaa et al.
In the amniote embryo, the upper jaw and nasal cavities form through coordinated outgrowth and fusion of craniofacial prominences. Adjacent to the embryonic prominences are the developing eyes, which abut the maxillary and lateral nasal pro...
Transcriptome analysis of axolotl oropharyngeal explants during taste bud differentiation stages [0.03%]
墨西哥钝口螈口腔咽部味蕾分化时期的转录组分析
Priya Kohli,Lauren Marazzi,Deborah Eastman
Priya Kohli
The Mexican salamander, Ambystoma mexicanum (Axolotl), is an excellent vertebrate model system to understand development and regeneration. Studies in axolotl embryos have provided important insights into taste bud development. Taste bud spe...
Claudin-7b and Claudin-h are required for controlling cilia morphogenesis in the zebrafish kidney [0.03%]
Claudin-7b 和 Claudin-h 对斑马鱼肾脏纤毛形态发生是必需的
Miaomiao Jin,Donglian Wang,Wenyan Xu et al.
Miaomiao Jin et al.
Claudins are a family of proteins which are the most important components of the tight junctions. The location of Claudins on the renal tubule epithelial determines its paracellular transport characteristics, but whether Claudins have other...
Jinsung Lim,Chong Pyo Choe
Jinsung Lim
The segment-polarity gene engrailed is required for segmentation in the early Drosophila embryo. Loss of Engrailed function results in segmentation defects that vary in severity from pair-rule phenotypes to a lawn phenotype lacking in obvio...
Regulation of Numb during planar cell polarity establishment in the Drosophila eye [0.03%]
Numb在果蝇眼睛平面细胞极性建立过程中的调控作用
Pedro M Domingos,Andreas Jenny,Keon F Combie et al.
Pedro M Domingos et al.
The establishment of planar cell polarity (PCP) in the Drosophila eye requires correct specification of the R3/R4 pair of photoreceptor cells, determined by a Frizzled mediated signaling event that specifies R3 and induces Delta to activate...
Editorial "MOD" [0.03%]
编者按：“模”不虚传
Roberto Mayor
Roberto Mayor