Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate [0.03%]
小鼠原肠运动：组织模式、细胞谱系决定及多样化的协调作用
Evan S Bardot,Anna-Katerina Hadjantonakis
Evan S Bardot
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and ectoderm. During gastrulation, a spatiotemporally controlled s...
Sylvia A Hilliard,Yuwen Li,Angelina Dixon et al.
Sylvia A Hilliard et al.
The antagonism between Mdm2 and its close homolog Mdm4 (also known as MdmX) and p53 is vital for embryogenesis and organogenesis. Previously, we demonstrated that targeted disruption of Mdm2 in the Hoxb7+ ureteric bud (Ub) lineage, which gi...
Second heart field-specific expression of Nkx2-5 requires promoter proximal interaction with Srf [0.03%]
Nkx2-5第二心脏场特异性表达需要与Srf的启动子附近相互作用
Christopher D Clark,Kyu-Ho Lee
Christopher D Clark
The cardiac homeobox transcription factor Nkx2-5 is a major determinant of cardiac identity and cardiac morphogenesis. Nkx2-5 operates as part of a complex and mutually reinforcing network of early transcription factors of the homeobox, GAT...
Regulation of axial and head patterning during planarian regeneration by a commensal bacterium [0.03%]
一种内共生细菌对涡虫再生过程中轴极和头部图案形成的调节作用
Katherine B Williams,Johanna Bischof,Frederick J Lee et al.
Katherine B Williams et al.
Some animals, such as planaria, can regenerate complex anatomical structures in a process regulated by genetic and biophysical factors, but additional external inputs into regeneration remain to be uncovered. Microbial communities inhabitin...
Wancong Zhang,Hanxing Zhao,Jiasheng Chen et al.
Wancong Zhang et al.
Background: Recent studies have shown that lipid metabolism was abnormal during the formation of cleft palate. However, the composition of these lipid species remains unclear. ...
Long noncoding RNA XIST regulates osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting miR-9-5p [0.03%]
长链非编码RNA XIST通过靶向miR-9-5p调节人骨髓间充质干细胞成骨分化功能
Chenying Zheng,Chunxiao Bai,Qi Sun et al.
Chenying Zheng et al.
This study aimed to investigate whether X inactivate-specific transcript (XIST) regulated the expression of tissue non-specific alkaline phosphatase (ALPL) through miR-9-5p to promote osteogenic differentiation of human bone marrow-derived ...
Postnatal development in the rat: Changes in Na+ flux, sodium pump molecular activity and membrane lipid composition [0.03%]
大鼠产后发育过程中钠离子转运、钠泵分子活性和膜脂组成的变化
Paul L Else
Paul L Else
The cellular mechanisms underpinning changes in metabolism during postnatal development in young mammals have not been extensively examined. This study examines changes in sodium pump capacity (Na+, K+-ATPase activity), number and molecular...
Binary fission in Trichoplax is orthogonal to the subsequent division plane [0.03%]
三倍体刺参种间杂交后代的胚雄株的产生及遗传组成分析
Jorge Zuccolotto-Arellano,Rodrigo Cuervo-González
Jorge Zuccolotto-Arellano
Asexual reproduction in Trichoplax occurs mainly by binary fission and occasionally by the budding of epithelial spheres called "swarmers". The process that leads to binary fission and the mechanisms involved in this segregation are practic...
MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 α inhibitor (HIF1AN) [0.03%]
microRNA-1-3p通过与缺氧诱导因子1α抑制剂(HIF1AN)互作促进MC3T3-E1细胞成骨分化
Long Zhou,Min Qiu,Lei Yang et al.
Long Zhou et al.
Studies have proved that miRNAs participate in the regulation of osteoblast differentiation (OD), and abnormal expression of miRNAs is related with various states of OD. In this study, we investigated the role of miRNA-1-3p in OD using MC3T...
HYDIN loss-of-function inhibits GATA4 expression and enhances atrial septal defect risk [0.03%]
功能丧失型HYDIN通过抑制GATA4的表达增强房间隔缺损风险
Yu Cao,Junying Guo,Jinping Zhang et al.
Yu Cao et al.
Background: Mutations affecting cardiac structural genes can lead to congenital heart diseases (CHDs). Axonemal Central Pair Apparatus Protein (HYDIN) is a ciliary protein previously linked to congenital cardiomyopathy. H...