β-Cell specific transcription factors in the context of diabetes mellitus and β-cell regeneration [0.03%]
糖尿病和β细胞再生背景下的β细胞特异性转录因子
Sivasangari Balakrishnan,Sugasini Dhavamani,Chidambaram Prahalathan
Sivasangari Balakrishnan
All pancreatic cell populations arise from the standard gut endoderm layer in developing embryos, requiring a regulatory gene network to originate and maintain endocrine lineages and endocrine function. The pancreatic organogenesis is regul...
P311 regulates distal lung development via its interaction with several binding proteins [0.03%]
P311通过与多种结合蛋白的相互作用调控远端肺发育
Yu Liu,Xiaohai Zhou,Naiyue Hu et al.
Yu Liu et al.
Little is known about the molecular mechanisms underlying alveolar development. P311, a putative neuronal protein originally identified for its high expression during neuronal development, has once been reported to play a potential role in ...
The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae [0.03%]
抗癫痫药物丙戊酸盐导致斑马鱼胚胎颅面骨骼畸形
I G E Gebuijs,J R Metz,J Zethof et al.
I G E Gebuijs et al.
Valproic acid (VPA) is an anti-epileptic drug known to cause congenital craniofacial abnormalities, including orofacial clefts (OFC). The exact mechanisms by which VPA leads to craniofacial skeletal malformations are poorly understood. In t...
Changes in characteristics of murine hair follicles and tissue stem cells by aging [0.03%]
衰老对小鼠毛囊特性及组织干细胞的影响
Kimihiko Sugaya
Kimihiko Sugaya
The aging process is closely related to the organization of stem cells, and skin is thought to be one of the suitable models for its investigation. We have focused on the murine hair follicle to verify this idea because it shows typical agi...
Gastrulation in Drosophila melanogaster: Genetic control, cellular basis and biomechanics [0.03%]
果蝇的原肠胚形成：基因调控、细胞基础与生物力学
Elham Gheisari,Mostafa Aakhte,H-Arno J Müller
Elham Gheisari
Gastrulation is generally understood as the morphogenetic processes that result in the spatial organization of the blastomere into the three germ layers, ectoderm, mesoderm and endoderm. This review summarizes our current knowledge of the m...
Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians [0.03%]
球核海葵（Nematostella vectensis）和其他腔肠动物的原肠胚形成及胚层形成
Ulrich Technau
Ulrich Technau
Among the basally branching metazoans, cnidarians display well-defined gastrulation processes leading to a diploblastic body plan, consisting of an endodermal and an ectodermal cell layer. As the outgroup to all Bilateria, cnidarians are an...
CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy [0.03%]
CFTR缺乏在斑马鱼胚胎发生过程中导致心脏发育不良并与扩张型心肌病相关
Yanyan Liu,Ziyuan Lin,Mingfeng Liu et al.
Yanyan Liu et al.
Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, w...
Guillermo Serrano Nájera,Cornelis J Weijer
Guillermo Serrano Nájera
Gastrulation consists in the dramatic reorganisation of the epiblast, a one-cell thick epithelial sheet, into a multilayered embryo. In chick, the formation of the internal layers requires the generation of a macroscopic convection-like flo...
Ashley E E Bruce,Rudolf Winklbauer
Ashley E E Bruce
The Brachyury gene encodes a transcription factor that is conserved across all animals. In non-chordate metazoans, brachyury is primarily expressed in ectoderm regions that are added to the endodermal gut during development, and often form ...
Wing patterning in faster developing Drosophila is associated with high ecdysone titer and wingless expression [0.03%]
发育较快的果蝇翅膀图案与高浓度蜕皮激素及wingless表达有关
Namita Chauhan,Nidhi Krishna Shrivastava,Namita Agrawal et al.
Namita Chauhan et al.
'Developmental robustness' is the ability of biological systems to maintain a stable phenotype despite genetic, environmental or physiological perturbations. In holometabolous insects, accurate patterning and development is guaranteed by al...