Activation of PPARα by gemfibrozil lowers tau-associated neuropathology in the MAPT mouse model of Alzheimer's disease [0.03%]
贝特类药物通过激活PPARα降低tau蛋白相关病变：来自MAPT小鼠模型的研究证据
Moumita Majumder,Debashis Dutta,Ramesh K Paidi et al.
Moumita Majumder et al.
The current dogma states that inhibiting tau accumulation and its associated neuropathologies might be a relevant strategy to prevent neuronal loss and cognitive dysfunction in Alzheimer's disease (AD). The present study demonstrates the th...
APOE4 exacerbates post-stroke cognitive impairments and Aβ deposition in a photothrombotic mouse model [0.03%]
APOE4在光凝血小鼠模型中加重卒中的认知功能障碍和淀粉样蛋白沉积
Xiang-Yu Liu,Jia-Xing Yuan,Cheng Wu et al.
Xiang-Yu Liu et al.
Background: Apolipoprotein E4 (APOE4) is considered a potential risk factor for post-stroke cognitive impairment (PSCI); however, clinical evidence remains conflicting and the mechanisms are poorly understood. Amyloid-β ...
ZFP36 attenuates neuronal apoptosis and pyroptosis through inhibiting TXNIP/NLRP3 pathway in hypoxic-ischemic brain damage [0.03%]
ZFP36通过抑制TXNIP/NLRP3途径缓解缺氧缺血性脑损伤中的神经元凋亡和焦亡
Hengjiang Guo,Yan Jiang,Zhiqing Gu et al.
Hengjiang Guo et al.
Hypoxic-ischemic brain damage (HIBD) is a major cause of neonatal mortality and long-term neurological impairment. Neuroinflammation plays a critical role in neuronal injury following HIBD. Zinc finger protein 36 (ZFP36), an RNA-binding pro...
Effects of anodal transcranial direct current stimulation over the right posterior parietal cortex on Simon task and flanker task performance [0.03%]
阳极经颅直流电刺激对右半球顶叶皮层的工作记忆及注意控制的影响
Sho Kojima,Kako Tanabe,Mitsuki Todoroki et al.
Sho Kojima et al.
Introduction: Stimulus-response compatibility (SRC) tasks test cognitive judgment by requiring discrimination between relevant and irrelevant information. This study explored the effects of anodal transcranial direct curr...
Hyperandrogenism associated deregulation of hippocampal adipokines may contribute to impaired memory function in mice [0.03%]
与多囊卵巢综合征相关的海马脂肪细胞因子异常可能导致小鼠记忆功能受损
Ayushmita Dutta,Rahul Kumar,Guruswami Gurusubramanian et al.
Ayushmita Dutta et al.
The elevated androgens and is called as hyperandrogenemia. Despite endocrinological imbalances, hyperandrogenism has also been linked to slight impairment in the cognitive functions along with depression and anxiety. Since the hippocampus r...
ZNF655-mediated neuroprotection in cerebral ischemia-reperfusion injury via Akt/Nrf2 pathway modulation [0.03%]
锌指蛋白655通过调节Akt/Nrf2信号通路介导脑缺血再灌注损伤的神经保护作用
Wanyi Wei,Zongkai Wu,Yuehong Yue et al.
Wanyi Wei et al.
Background: Cerebral ischemia-reperfusion injury (CIRI) involves complex pathological processes, including oxidative stress, inflammatory responses, and apoptosis. Zinc finger protein 655 (ZNF655) is implicated in the reg...
An organ-on-a-chip investigation into dose-dependent, temporal dynamic effects of radiosurgery on the blood-brain barrier and its immunological response [0.03%]
一项关于放射外科手术对血脑屏障及其免疫反应的剂量依赖性和时间动态效应的器官芯片研究
Adam D Yock,Jacquelyn A Brown,John Eley et al.
Adam D Yock et al.
Purpose: This work used an organ-on-a-chip (OOC) model of the blood-brain barrier (BBB) to study effects of clinical radiation on barrier permeability and cytokine concentrations. ...
Evolution of users' subjective experience over three training sessions with an EEG Motor-Imagery Brain-Computer Interface (MI-BCI) [0.03%]
基于三节训练课程的脑电图运动想象脑机接口的用户主观体验演变规律研究
Aline Roc,Léna Kolodzienski,Pauline Dreyer et al.
Aline Roc et al.
Motor Imagery-based Brain-Computer Interfaces (MI-BCIs) have been shown to be promising for numerous applications, including sport training and entertainment for healthy users, but also for improving or restoring functions in neurological a...
Spatiotemporal profiling of endocytic regulators in the immunosuppressive TAM microenvironment of glioma [0.03%]
胶质瘤免疫抑制性TAM微环境的内吞调节剂时空谱型分析
Shi Hua,Yanhao Cheng,Dai Chao et al.
Shi Hua et al.
Endocytosis plays a pivotal role in shaping the immunosuppressive landscape of gliomas, yet its spatial dynamics within the tumor microenvironment remain incompletely understood. Here, we integrated single-cell and spatial transcriptomic an...
Abdulkerim Darendeli,Mathew Yarossi,Spencer Lake Jakobs-Skolik et al.
Abdulkerim Darendeli et al.
The generation of muscle force is a key component of movement. Force is generated by increasing the number and firing rates of motor units (MU), but limited information is available on the corticospinal (CS) recruitment gain across the spec...