Effects of interferon therapy on development of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis: A meta-analysis of randomized controlled trials [0.03%]
干扰素治疗对肝炎C相关肝硬化患者肝癌发展的效果：随机对照试验的meta分析研究
Li-Shuai Qu,Hong Chen,Xiao-Ling Kuai et al.
Li-Shuai Qu et al.
Aim: The role of interferon (IFN) therapy on prevention of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related cirrhosis remains controversial. This meta-analysis aimed to determine whether IF...
Ca(2+) /calmodulin- dependent protein kinase II mediates transforming growth factor-β-induced hepatic stellate cells proliferation but not in collagen α1(I) production [0.03%]
钙/钙调素依赖性蛋白激酶II介导转化生长因子-β诱导的肝星状细胞增殖但不参与胶原α1(I)生成
Ping An,Yihao Tian,Mingkai Chen et al.
Ping An et al.
Aim: Hepatic stellate cells (HSC) are the major players in hepatic fibrosis. As a most potent mitogen, transforming growth factor-β (TGF-β) strongly activates HSC and increases intracellular Ca(2+) concentration. Here,...
Ti Zhang,Heping Liu,Cihui Zhu et al.
Ti Zhang et al.
Aim: Although thioredoxin 1 (TXN) has pleiotropic cellular functions as a redox-sensitive protein, very little is known about its role in tumor survival and growth under hypoxia. MHCC97H hepatocellular carcinoma cells ha...
Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis [0.03%]
骨髓和肝脏在肝纤维化发病机制中的相互作用
Yutaka Inagaki,Reiichi Higashiyama
Yutaka Inagaki
Recent advances in the technologies of both molecular biology and regenerative medicine have made it possible to identify bone marrow (BM)-derived cells migrating into various fibrotic organs including the liver. A number of studies have re...
Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats [0.03%]
脑芬对脂多糖诱导大鼠肝细胞凋亡的抑制作用及线粒体信号通路的影响研究
Jun-Hua Fan,Guo-Gang Feng,Lei Huang et al.
Jun-Hua Fan et al.
Aim: Lipopolysaccharide (LPS) causes apoptosis of hepatocytes, which is probably mediated by inflammatory substances released from Kupffer cells (KCs). Recently, we have reported that naofen, a newly found intracellular ...
Risk factors for mother-to-child transmission of hepatitis C virus: Maternal high viral load and fetal exposure in the birth canal [0.03%]
母亲高病毒载量和胎儿在产道内暴露是母子垂直传播丙型肝炎病毒感染的危险因素
Jun Murakami,Ikuo Nagata,Toshiyuki Iitsuka et al.
Jun Murakami et al.
Aim: Mother-to-child transmission (MTCT) is the major transmission pathway of hepatitis C virus (HCV) in children. However, its risk factors remain unsettled for introduction of putative intervention. ...
Follow up of the 987 blood donors found with hepatitis C virus infection over 9-18 years [0.03%]
987名丙型肝炎病毒感染血浆捐献者长期随访研究
Junko Matsuo,Masaaki Mizui,Hajime Okita et al.
Junko Matsuo et al.
Aim: To follow up blood donors found with hepatitis C virus (HCV) infection, to improve the outcome by antiviral treatments. Methods: ...
Comparison of the metabolic profiling of hepatitis B virus-infected cirrhosis and alcoholic cirrhosis patients by using (1) H NMR-based metabonomics [0.03%]
~ ~(1)H
Suwen Qi,Zhiguang Tu,Xin Ouyang et al.
Suwen Qi et al.
Aim: The aims of the present study were to depict the serum metabolic characteristics of hepatitis B virus (HBV)-infected cirrhosis and alcoholic cirrhosis patients, and to find the specific serum biomarkers associated w...
Factor XIII Val34Leu mutation accelerates the development of fibrosis in patients with chronic hepatitis B and C [0.03%]
因慢性乙型和丙型肝炎导致纤维化发展的患者中因子ⅩⅢ Val34Leu突变加速了纤维化的发展
Kathelijne Dik,Joep de Bruijne,R Bart Takkenberg et al.
Kathelijne Dik et al.
Aim: There is considerable variation in liver fibrosis stage and progression to cirrhosis among patients with chronic hepatitis B (CHB) or C (CHC). Coagulation pathway activity due to genetic variations could influence t...
Late-evening snack with branched-chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma [0.03%]
射频消融治疗肝细胞癌后的晚间含支链氨基酸点心可改善肝功能
Daisuke Morihara,Kaoru Iwata,Takayuki Hanano et al.
Daisuke Morihara et al.
Aim: This prospective study was designed to examine whether consumption of a branched-chain amino acid (BCAA)-enriched nutrient mixture as a late-evening snack (LES) helps maintain and/or improve liver functioning in liv...