Jian Jiao,Jiangbin Wang,Matii Sallberg
Jian Jiao
Hepatits C virus (HCV) is an enveloped virus with positive-sense single-stranded RNA genome that causes both acute and persistent infections associated with chronic hepatitis, cirrhosis and hepatocellular carcinoma, which needs fully functi...
Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis [0.03%]
HCV核心区域氨基酸替换对多阶段肝癌发生的影响
Takasuke Fukuhara,Kazuki Takeishi,Takeo Toshima et al.
Takasuke Fukuhara et al.
Aim: The core protein of hepatitis C virus (HCV) has multiple functions for not only viral replication but also hepatocellular carcinogenesis. A significant association of the substitutions in the core region with hepatoc...
Interstitial chemotherapy using thermosensitive gel-coated ricin in nude mice bearing a human hepatoma [0.03%]
裸鼠人肝癌模型的夹心热敏凝胶制剂蓖麻毒素局部化疗
Zhi-Kui Chen,Li-Wu Lin,Yinghong Yang et al.
Zhi-Kui Chen et al.
Aim: To investigate the anti-tumor effects and mechanisms of interstitial chemotherapy using intra-tumor injection of thermosensitive gel-coated ricin in nude mice bearing a human hepatoma. ...
Susceptibility to experimental biliary atresia linked to different hepatic gene expression profiles in two mouse strains [0.03%]
与两种小鼠品系不同的肝基因表达模式相联系的实验性胆道闭锁易感性
Johannes Leonhardt,Joachim F Kuebler,Carmen Turowski et al.
Johannes Leonhardt et al.
Aim: To compare hepatic gene expression during the development of experimental biliary atresia (BA) in two different mouse strains. Methods: ...
Role of Kupffer cells in the outgrowth of colorectal cancer liver metastases [0.03%]
库普弗细胞在结直肠癌肝转移灶生长中的作用
Konstantinos A Paschos,Ali W Majeed,Nigel C Bird
Konstantinos A Paschos
Colorectal cancer is one of the commonest malignancies in the "developed" world. The liver constitutes the main host organ for its distant metastases which, when present, augur a bad prognosis for the disease. Kupffer cells (KCs) are macrop...
Antiangiogenesis gene armed tumor-targeting adenovirus yields multiple antitumor activities in human HCC xenografts in nude mice [0.03%]
武装抗血管生成基因的肿瘤靶向腺病毒治疗人类肝癌裸鼠移植瘤疗效研究
Lin Fang,Ying-Yan Pu,Xiao-Cui Hu et al.
Lin Fang et al.
Aim: Gene therapy represents a promising therapeutic strategy for hepatocellular carcinoma (HCC). To improve the ratio of killing efficacy on tumor cells to side-effect on normal cells, we constructed an oncolytic adenovi...
Development of HCC in patients receiving adefovir dipivoxil for lamivudine-resistant hepatitis B virus mutants [0.03%]
替比夫定耐药的乙肝病毒患者接受阿德福韦二吡呋oxil治疗后发生肝细胞癌的发展情况
Tetsuya Hosaka,Fumitaka Suzuki,Masahiro Kobayashi et al.
Tetsuya Hosaka et al.
Aim: To identify factors for the development of hepatocellular carcinoma (HCC) in the patients who receive adefovir add-on lamivudine for treatment of lamivudine-resistant hepatitis B virus (HBV) mutants. ...
Molecular targets for liver cancer therapy: From screening of target genes to clinical trials [0.03%]
肝癌治疗的分子靶标研究：从靶基因筛选到临床试验
Yutaka Midorikawa,Yasuyuki Sugiyama,Hiroyuki Aburatani
Yutaka Midorikawa
Cancer arises from the accumulation of genetic alterations, and the inactivation of oncogenes, or recovery of suppressor genes, are promising strategies for cancer treatment. Genome-based drug research starts with identification of target g...
Cholestasis enhances liver ischemia/reperfusion-induced coagulation activation in rats [0.03%]
胆汁郁积增强肝缺血/再灌注大鼠凝血激活反应
Jaap J Kloek,Marcel Levi,Michal Heger et al.
Jaap J Kloek et al.
Aim: Cholestasis is associated with increased morbidity and mortality in patients undergoing major liver surgery. An additional risk is induced when vascular inflow occlusion is applied giving rise to liver ischemia/reper...
Role of angiotensin II in liver fibrosis-induced portal hypertension and therapeutic implications [0.03%]
肝纤维素诱导的门脉高压症中血管紧张素Ⅱ的作用及治疗意义
Alejandro Lugo-Baruqui,José Francisco Muñoz-Valle,Sigifredo Arévalo-Gallegos et al.
Alejandro Lugo-Baruqui et al.
Angiotensin II (AT-II) is a peptide that plays an important role in the renin-angiotensin-aldosterone (RAA) system. Traditionally, the RAA system has been related with states of systemic hypertension and hypoperfusion as a counterbalance me...