Fenretinide stimulates the apoptosis of hepatic stellate cells and ameliorates hepatic fibrosis in mice [0.03%]
芬retenidine通过促进肝星状细胞的凋亡改善小鼠肝脏纤维化
Jin Qian,Jin Sheng Zhang,Xue Qing Wang et al.
Jin Qian et al.
Aim: To investigate whether fenretinide, a clinically proved apoptosis-inducing chemopreventive agent in tumor cells, can induce apoptosis in hepatic stellate cells (HSCs) and resolve hepatic fibrosis. ...
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis [0.03%]
肝癌中EphA2、MMP-9和CD34阳性微血管密度的高表达：对肿瘤进展及预后的影响
Pu Yang,Weijie Yuan,Jiantai He et al.
Pu Yang et al.
Aim: To investigate the expression of erythropoietin-producing hepatocellular (Eph)A2 receptor, matrix metalloproteinase (MMP)-9, and angiogenesis in hepatocellular carcinoma (HCC), in order to reveal their expression cor...
Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms [0.03%]
间充质干细胞抑制肝星状细胞增殖及其可能机制研究
Jing Wang,Chunjing Bian,Lianming Liao et al.
Jing Wang et al.
Aim: During fibrosis, hepatic stellate cells (HSCs) undergo a complex activation process characterized by increased proliferation and extracellular matrix deposition. Previous studies have suggested that mesenchymal stem ...
Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment [0.03%]
替比夫定治疗中乙肝病毒DNA和血清ALT水平与YMDD突变及突破性乙型肝炎的相关性研究
Mariko Kobayashi,Fumitaka Suzuki,Norio Akuta et al.
Mariko Kobayashi et al.
Aim: Continuous lamivudine treatment is associated with high frequency of drug resistance. We analyzed the incidence of tyrosine-methionine-aspartate-aspartate (YMDD) motif mutant and breakthrough hepatitis (BTH) in hepat...
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection [0.03%]
APOBEC3A和APOBEC3B基因结构变异在慢性乙型肝炎病毒感染中作用的研究进展
Hiromi Abe,Hidenori Ochi,Toshiro Maekawa et al.
Hiromi Abe et al.
Aim: Human APOBEC3 deaminases induce G to A hypermutation in nascent DNA strand of hepatitis B virus (HBV) genomes and seem to operate as part of the innate antiviral immune system. We analyzed the importance of APOBEC3A ...
Prolonged treatment with pegylated interferon alpha 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan [0.03%]
佩加素干扰素α-2b联合利巴韦林对日本临床真实世界慢性丙型肝炎基因1型晚期治疗应答患者的持续病毒学应答的影响
Sumio Watanabe,Nobuyuki Enomoto,Kazuhiko Koike et al.
Sumio Watanabe et al.
Aim: This study was conducted to clarify the factors related to sustained virological response (SVR) to pegylated interferon alpha 2b (PEG-IFN) plus ribavirin (RBV) combination therapy administered for 48 weeks in patient...
Altered regulation of extrinsic apoptosis pathway in HCV-infected HCC cells enhances susceptibility to mapatumumab-induced apoptosis [0.03%]
丙型肝炎病毒感染的肝癌细胞中调节凋亡通路的改变使其易发生mapatumumab诱导的凋亡
Xiaozhen Zhang,Astrid C Frank,Christine M Gille et al.
Xiaozhen Zhang et al.
Background: Hepatitis C virus (HCV)-infected patients, including those co-infected with human immunodeficiency virus (HIV), are at increased risk of developing hepatocellular carcinoma (HCC). We evaluated the ability of a...
Hematoporphyrin derivative-mediated photodynamic therapy inhibits tumor growth in human cholangiocarcinoma in vitro and in vivo [0.03%]
血卟啉衍生物介导的光动力疗法抑制人胆管癌的体内和体外增殖
Liang-Qi Cao,Ping Xue,Hai-Wu Lu et al.
Liang-Qi Cao et al.
Aim: To investigate the effects of hematoporphyrin derivative-mediated photodynamic therapy (HPD-PDT) on cell growth in human cholangiocarcinoma in vitro and in vivo, as well as the underlying mechanisms of these effects....
Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure [0.03%]
肝炎相关急性-on-慢性肝功能衰竭患者肝脏免疫细胞外渗及隔绝作用的研究
Zhengsheng Zou,Dongping Xu,Baosen Li et al.
Zhengsheng Zou et al.
Aims: This study attempts to characterize the feature of immunologically competent cells (ICCs) and evaluate its clinical implication in patients with acute-on-chronic liver failure (ACLF) in relation to chronic hepatitis...