Highly active antiretroviral therapy improved persistent lamivudine-resistant viremia in acute hepatitis B virus genotype Ae infection with coinfection of human immunodeficiency virus [0.03%]
高效抗逆转录病毒治疗可改善人免疫缺陷病毒共感染的乙型肝炎e基因型Ae急性感染者拉米夫定耐药病毒血症持续存在的问题
Mashu Aizawa,Akihito Tsubota,Kiyotaka Fujise et al.
Mashu Aizawa et al.
A 57-year-old man developed acute hepatitis B virus (AHB), caused by HBV genotype Ae. Lamivudine (LAM) therapy was started at 8 months after the disease onset, because the infection was persistent, but not self-limited. Despite LAM therapy,...
Evaluation for clinical utility of GPC3, measured by a commercially available ELISA kit with Glypican-3 (GPC3) antibody, as a serological and histological marker for hepatocellular carcinoma [0.03%]
甘帕克汀-3抗体商品化酶联免疫吸附试验盒检测甘帕克汀-3对肝细胞癌的临床应用价值评估研究
Eisuke Yasuda,Takashi Kumada,Hidenori Toyoda et al.
Eisuke Yasuda et al.
Aims: We evaluated the clinical utility of glypican-3 (GPC3), which has been proposed as a potential novel tumor marker for hepatocellular carcinoma (HCC), as a serological and histological marker for HCC. ...
Dendritic cells fused with allogeneic hepatocellular carcinoma cell line compared with fused autologous tumor cells as hepatocellular carcinoma vaccines [0.03%]
异基因肝癌细胞系融合树突状细胞疫苗与自体肿瘤融合细胞疫苗的比较研究
Jing-Yue Yang,Da-Yong Cao,Long-Yang Ma et al.
Jing-Yue Yang et al.
Purpose: To investigate the specific antitumor responses against autologous hepatocellular carcinoma (HCC) cells of dendritic cells (DCs) fused with allogeneic HCC cell line, and evaluated the feasibility of BEL7402 as an...
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet [0.03%]
利用甲硫氨酸和卵磷脂缺乏性饮食喂养的叙利亚仓鼠肝组织中,卡莫西姆酶抑制剂可预防非酒精性脂肪性肝炎发生
Keitaro Tashiro,Shinji Takai,Denan Jin et al.
Keitaro Tashiro et al.
Aim: Mast cells may be involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). The mast cell protease chymase contributes to the formation of angiotensin II and matrix metalloproteinase (MMP)-9, both of which...
Portal vein thrombosis in Egyptian patients with liver cirrhosis: Role of methylenetetrahydrofolate reductase C677T gene mutation [0.03%]
门静脉血栓形成在埃及肝硬化患者中的发病情况及甲基四氢叶酸还原酶C677T基因突变的作用
Mamdouh Ahmed Gabr,Sahar Saad El-Din Bessa,Enas Arafa El-Zamarani
Mamdouh Ahmed Gabr
Aim: The pathogenesis of non-malignant portal vein thrombosis (PVT) in cirrhotic patients is not clearly defined. This case-control study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR) C677T ...
Effect of genipin on cholestasis induced by estradiol-17beta-glucuronide and lithocholate-3-O-glucuornide in rats [0.03%]
牻牛儿酮对雌二醇-葡萄糖醛酸苷和鹅去氧胆酸-葡萄糖醛酸苷致大鼠肝胆汁淤积的影响
Hideaki Goto,Hajime Takikawa
Hideaki Goto
Aim: Genipin is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in the bile canalicular membrane, thereby causing choleresis by the increased the biliary excretion of glutathione, which has be...
Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): The HLA-DRB1polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC [0.03%]
日本原发性胆汁肝硬化的HLA-DRB1多态性分析：HLA-DRB1多态性决定抗核抗体对原发性胆汁性肝硬化疾病发展的相对危险度
Minoru Nakamura,Michio Yasunami,Hisayoshi Kondo et al.
Minoru Nakamura et al.
Aims: Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis (PBC). However, the association of human leukocyte antigen (HLA) polymorphisms with these risk fa...
Identification of a novel biomarker for oxidative stress induced by hydrogen peroxide in primary human hepatocytes using the 2-nitrobenzenesulfenyl chloride isotope labeling method [0.03%]
一种新型生物标志物的鉴定：在人肝细胞中使用2-硝基苯磺烯氯化物同位素标记法鉴定由过氧化氢诱导的氧化应激生物标志物
Yoichiro Takami,Hirofumi Uto,Tsutomu Tamai et al.
Yoichiro Takami et al.
Aim: Oxidative stress is involved in the progression of non-alcoholic steatohepatitis (NASH). However, there are few biomarkers that are easily measured and accurately reflect the disease states. The aim of this study was...
Kojiro Michitaka,Atsushi Hiraoka,Misaki Kume et al.
Kojiro Michitaka et al.
Aim: The aim of this study is to clarify the amino acid imbalance in patients with chronic hepatitis (CH) as well as those with liver cirrhosis (LC). Meth...