Paternal isodisomy of chromosome 2 in a child with bile salt export pump deficiency [0.03%]
父系二体性2号染色体上胆盐出口泵缺乏患儿的基因型分析
Isabella Giovannoni,Alessandra Terracciano,Fabrizio Gennari et al.
Isabella Giovannoni et al.
We describe a child with progressive familial intrahepatic cholestasis (PFIC) of type 2 inherited as uniparental isodisomy of chromosome 2. Bile salt export pump (BSEP) deficiency is a severe, genetically determined subtype PFIC caused by m...
Dietary fish oil regulates gene expression of cholesterol and bile acid transporters in mice [0.03%]
膳食鱼油调节小鼠胆固醇和胆汁酸转运蛋白的基因表达
Toshinori Kamisako,Yuji Tanaka,Takanori Ikeda et al.
Toshinori Kamisako et al.
Aim: Fish oil rich in n-3 polyunsaturated fatty acids is known to affect hepatic lipid metabolism. Several studies have demonstrated that fish oil may affect the bile acid metabolism as well as lipid metabolism, whereas ...
Influence of chronic stress on the compositions of hepatic cholesterol and triglyceride in male Wistar rats fed a high fat diet [0.03%]
慢性应激对高脂膳食Wistar大鼠肝脏胆固醇和甘油三酯含量的影响
Siyuan Gao,Xue Han,Jihua Fu et al.
Siyuan Gao et al.
Aim: We determined the influence of chronic stress (CS) on the compositions of hepatic cholesterol and triglyceride (TG) in rats fed a high fat diet (HFD). ...
Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2 [0.03%]
基于应答的慢性丙型肝炎患者高HCV-RNA（基因2型）治疗方案研究
Yasunori Yamaguchi,Akihiro Tamori,Yasuhito Tanaka et al.
Yasunori Yamaguchi et al.
Aim: We evaluated the efficacy of response-guided therapy in patients with hepatitis C virus (HCV) genotype 2. Methods: We studied 10...
Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma [0.03%]
非癌性肝组织中c-Jun氨基末端激酶活化预测肝细胞癌肝切除术后高复发风险
Satoru Hagiwara,Masatoshi Kudo,Hobyung Chung et al.
Satoru Hagiwara et al.
Aim: Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer deaths worldwide. Hepatic resection is the mainstay of curative treatment for early stage HCC. Although c-Jun N-terminal kinase (JNK) activat...
Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma [0.03%]
肝癌超老年患者肝脏切除术的疗效分析
Shinichiro Yamada,Mitsuo Shimada,Hidenori Miyake et al.
Shinichiro Yamada et al.
Aim: The aim of this study was to investigate the characteristics of super-elderly hepatocellular carcinoma (HCC) patients aged 80 years or more who underwent hepatectomy and to clarify whether elderly patients with HCC ...
ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score [0.03%]
与Child-Turcotte-Pugh评分和终末期肝病模型评分相比，ADAMTS13活性可能是肝硬化患者累计生存率的预测指标
Hiroaki Takaya,Masahito Uemura,Yoshihiro Fujimura et al.
Hiroaki Takaya et al.
Aim: Decreased plasma ADAMTS13 activity (ADAMTS13:AC) results in accumulation of unusually large von Willebrand factor multimers and platelet thrombi formation. Our aim was to evaluate whether ADAMTS13:AC is a prognostic...
Effect of interferon therapy on first and second recurrence after resection of hepatitis C virus-related hepatocellular carcinoma [0.03%]
干扰素治疗对乙肝相关性肝癌术后第一次和第二次复发的影响
Masayuki Sakae,Shoji Kubo,Shigekazu Takemura et al.
Masayuki Sakae et al.
Aim: Several investigators have shown that interferon (IFN) therapy can suppress the recurrence of hepatocellular carcinoma (HCC) after curative treatment. We investigated the effect of IFN therapy on the first and secon...
Association between transforming growth factor-β1 polymorphisms and hepatocellular cancer risk: A meta-analysis [0.03%]
转化生长因子-β1基因多态性与肝细胞癌发病风险的相关性：一项荟萃分析
Tian-Xin Xiang,Na Cheng,Xi-Nv Li et al.
Tian-Xin Xiang et al.
Aim: The association between transforming growth factor-β1 (TGF-β1) gene polymorphisms and hepatocellular cancer (HCC) risk has been widely reported, but results were somewhat controversial. To derive a more precise es...
Usefulness of Technetium-99 m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease [0.03%]
99mTc-MIBI肝闪烁显像在评价非酒精性脂肪肝病活动度中的作用研究
Kosei Masuda,Masafumi Ono,Mitsutaka Fukumoto et al.
Kosei Masuda et al.
Aim: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD). Therefore, it is important to evaluate disease activity and distinguish NASH from simple steatosis in NAFLD. T...