Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review [0.03%]
非洲裔美国妇女乳腺癌的城乡社区及居住因素：系统评价研究
Brandi Patrice Smith,Zeynep Madak-Erdogan
Brandi Patrice Smith
Residential characteristics in urban neighborhoods impact health and might be important factors contributing to health disparities, especially in the African American population. The purpose of this systematic review is to understand the re...
Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer [0.03%]
甲状腺激素通过促进β-连环素活化和细胞增殖参与结直肠癌发生发展的作用机制研究
Yee-Shin Lee,Yu-Tang Chin,Ya-Jung Shih et al.
Yee-Shin Lee et al.
Thyroid hormone status has long been implicated in cancer development. Here we investigated the role of thyroxine (T4) in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant), as well as the primary cultures of cancer...
Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats [0.03%]
醋酸阿比特龙联合NVP-BEZ235对大鼠前列腺肿瘤进展的协同抑制作用
Bianca Facchim Gonçalves,Silvana Gisele Pegorin de Campos,Wagner José Fávaro et al.
Bianca Facchim Gonçalves et al.
Use of drug combinations that target different pathways involved in the development and progression of prostate cancer (PCa) has emerged as an alternative to overcome the resistance caused by drug monotherapies. The antiandrogen abiraterone...
Elevated Aromatase (CYP19A1) Expression Is Associated with a Poor Survival of Patients with Estrogen Receptor Positive Breast Cancer [0.03%]
雌激素受体阳性乳腺癌患者中芳烃酶(CYP19A1)高表达与预后不良相关
Andrea Friesenhengst,Tamara Pribitzer-Winner,Heidi Miedl et al.
Andrea Friesenhengst et al.
Genetic variants in CYP19A1, the gene encoding aromatase, have been reported to be associated with circulating estrogen concentrations, a key risk factor for breast cancer. The mechanism underlying this association is still unclear; it has ...
Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models [0.03%]
小鼠模型中肥胖与甲状腺癌发生发展的机制联系
Won Gu Kim,Sheue-Yann Cheng
Won Gu Kim
Recent compelling epidemiological studies indicate a strong association of obesity with thyroid cancer. Obesity has been shown to promote thyroid cancer progression and exacerbate poor outcome in thyroid cancer patients. However, the molecu...
Fasting Blood Glucose Level in Locally Advanced Non-Small Cell Lung Cancer: a New Prognostic Factor? [0.03%]
空腹血糖水平与局部晚期非小细胞肺癌预后的关系研究
Esra Korkmaz Kirakli,Ufuk Yilmaz,Hasan Yilmaz et al.
Esra Korkmaz Kirakli et al.
Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival ...
Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer [0.03%]
利用不同的依赖性：如何识别和针对雄激素受体阳性与四重阴性乳腺癌
Jessica L Christenson,Jane B Trepel,Haythem Y Ali et al.
Jessica L Christenson et al.
The androgen receptor (AR) is a promising therapeutic target for a subset of triple-negative breast cancers (TNBCs) in which AR is expressed. However, the mechanistic action of AR and the degree to which primary and metastatic tumors depend...
Kimberly A Bertrand,A Heather Eliassen,Susan E Hankinson et al.
Kimberly A Bertrand et al.
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal ...
Vladimir Djedovic,Yoo-Young Lee,Alexandra Kollara et al.
Vladimir Djedovic et al.
Adjuvant glucocorticoid treatment is routinely used in the treatment of ovarian cancer to mitigate the undesirable side effects of chemotherapy, thereby enhancing tolerability to higher cytotoxic drug doses and frequency of treatment cycles...
Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers [0.03%]
脂联素、瘦素和胰岛素信号通路受体作为子宫内膜癌分型标志物的研究
Evan L Busch,Marta Crous-Bou,Jennifer Prescott et al.
Evan L Busch et al.
Developing a system of molecular subtyping for endometrial tumors might improve insight into disease etiology and clinical prediction of patient outcomes. High body mass index (BMI) has been implicated in development of endometrial cancer t...