Circulating sex hormones and mammographic breast density among postmenopausal women [0.03%]
绝经后妇女血液循环中的性激素与乳腺密度的关系
Brian L Sprague,Amy Trentham-Dietz,Ronald E Gangnon et al.
Brian L Sprague et al.
The use of breast density as an intermediate or predictive marker of breast cancer risk is limited by an incomplete understanding of the etiology of breast density. High blood levels of endogenous estrogens and androgens are associated with...
Challenges and pitfalls in the management of parathyroid carcinoma: 17-year follow-up of a case and review of the literature [0.03%]
甲状旁腺癌的管理挑战和陷阱：一例长达17年的随访及文献回顾
Janneke E Witteveen,Harm R Haak,Job Kievit et al.
Janneke E Witteveen et al.
A 29-year-old man presented to his primary care physician with nausea, severe weight loss and muscle weakness. He had a hard, fixed neck swelling. He was severely hypercalcaemic with 10-fold increased parathyroid hormone (PTH) concentration...
Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers [0.03%]
雌激素、孕酮和表皮生长因子受体信号传导介导正常大鼠乳腺和依赖激素的大鼠乳腺癌中的Amphiregulin的作用
Anastasia Kariagina,Jianwei Xie,Jeffrey R Leipprandt et al.
Anastasia Kariagina et al.
Both estrogen (E) and progesterone (P) are implicated in the etiology of human breast cancer. Defining their mechanisms of action, particularly in vivo, is relevant to the prevention and therapy of breast cancer. We investigated the molecul...
Estrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner [0.03%]
雌激素通过凋亡抑制蛋白(IAP)依赖的方式促进乳腺癌细胞的存活
Adina Stanculescu,Leslie A Bembinster,Kristina Borgen et al.
Adina Stanculescu et al.
The estrogen receptor (ER) is a major prognostic and therapeutic marker that is expressed in nearly 75% of breast tumors. We have previously shown that the presence of inflammatory mediators can alter the genomic function of the estrogen re...
16 kDa prolactin reduces angiogenesis, but not growth of human breast cancer tumors in vivo [0.03%]
16千道尔顿的催乳素减少人乳腺癌肿瘤的血管生成但并不影响其生长
J M Faupel-Badger,E Ginsburg,J M Fleming et al.
J M Faupel-Badger et al.
Prolactin (PRL) is a peptide hormone necessary for normal growth and development of the human breast. In addition, high levels of PRL in plasma correlate with increased risk of breast cancer, especially among postmenopausal women. Several i...
Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes [0.03%]
静默的皮质促性腺细胞瘤：临床和细胞特征及长期预后分析
Odelia Cooper,Anat Ben-Shlomo,Vivien Bonert et al.
Odelia Cooper et al.
Silent corticotrophins adenomas (SCAs) are clinically silent and non-secreting but immunostain positively for ACTH. We hypothesize that SCAs comprise both corticotroph and gonadotroph characteristics. Cohort analysis from 1994-2008 with fol...
Mouse prostate cancer cell lines established from primary and postcastration recurrent tumors [0.03%]
原发性和去势复发性小鼠前列腺肿瘤细胞系的建立
Chun-Peng Liao,Mengmeng Liang,Michael B Cohen et al.
Chun-Peng Liao et al.
The clinical course of prostate cancer is grouped into two broad phases. The first phase, which is the growth of the androgen-dependent cancer (AD-Ca) responds well to androgen depletion treatment while the second phase, that could be terme...