Estrogen and progesterone in normal mammary gland development and in cancer [0.03%]
雌激素和孕酮在正常乳腺发育及癌症发生中的作用
John Stingl
John Stingl
There is emerging evidence that the mammary epithelium in both mice and humans is arranged as a hierarchy that spans from stem cells to differentiated hormone-sensing, milk-producing and myoepithelial cells. It is well established that estr...
Letter from the editor [0.03%]
主编来信
Jonathan J Li
Jonathan J Li
Alcohol exposure in utero leads to enhanced prepubertal mammary development and alterations in mammary IGF and estradiol systems [0.03%]
宫内接触酒精导致小鼠青春期前乳腺过度发育并影响其乳腺IGF和雌二醇系统
Tiffany A Polanco,Catina Crismale-Gann,Wendie S Cohick
Tiffany A Polanco
Exposure to alcohol during fetal development increases susceptibility to mammary cancer in adult rats. This study determined if early changes in mammary morphology and the insulin-like growth factor (IGF)/estradiol axis are involved in the ...
Expression of NHERF1 in colonic tumors induced by 1,2-dimethylhydrazine in rats is independent of plasma ovarian steroids [0.03%]
NHERF1在1,2-二甲基肼诱导的大鼠结肠肿瘤中的表达与血浆卵巢甾体无关
Mariana Troncoso,F Darío Cuello Carrión,Elina Guiñazu et al.
Mariana Troncoso et al.
In normal embryonic fibroblasts, the Na(+)/H(+) exchanger regulator factor 1 (NHERF1) stabilizes E-cadherin/β-catenin binding and the lack of NHERF1 expression promotes cell transformation thus acting as a tumor suppressor gene. We here te...
Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis [0.03%]
孕激素受体B诱导BIRC3以保护子宫内膜癌细胞免受AP1-59介导的凋亡影响
Nikki L Neubauer,Erin C Ward,Parin Patel et al.
Nikki L Neubauer et al.
Progesterone is a growth inhibitory hormone in the endometrium. While progestins can be used for the treatment of well-differentiated endometrial cancers, resistance to progestin therapy occurs for reasons that remain unclear. We have previ...
Inhibitory effects of calcitriol on the growth of MCF-7 breast cancer xenografts in nude mice: selective modulation of aromatase expression in vivo [0.03%]
1,25-二羟基维生素D3对MCF-7乳腺癌移植瘤生长的抑制作用及其对体内芳香化酶表达的选择性调节作用
Srilatha Swami,Aruna V Krishnan,Jennifer Y Wang et al.
Srilatha Swami et al.
Calcitriol (1,25-dihydroxyvitamin D(3)), the hormonally active metabolite of vitamin D, exerts many anticancer effects in breast cancer (BCa) cells. We have previously shown using cell culture models that calcitriol acts as a selective arom...
Luteinizing hormone receptor deficiency increases the susceptibility to alkylating agent-induced lymphomagenesis in mice [0.03%]
黄体生成素受体缺乏增加小鼠对烷基化剂诱导的淋巴瘤发生的易感性
Yinghao Yu,Fangping Yuan,Xian Li et al.
Yinghao Yu et al.
Previous studies have revealed a close link between luteinizing hormone (LH)/human chorionic gonadotropin (hCG) signaling and oncogenesis in gonadal and nongonadal tissues. To investigate whether genetic ablation of LH receptor (Lhr) affect...
Robert Treat Chatterton Jr,Noah P Parker,Mito Habe-Evans et al.
Robert Treat Chatterton Jr et al.
Lavage of the ductal systems of the breast provides fluid (DLF) containing hormones and products of hormone actions that may represent more accurately the composition of the breast than samples collected from blood or urine. The present stu...
Aniek Janssen,Geert J Kops,René H Medema
Aniek Janssen
One of the most common hallmarks of cancer cells is aneuploidy or an abnormal number of chromosomes. This abnormal chromosome content is a consequence of chromosome missegregation during mitosis, a defect that is seen more frequently in tum...
Hsing-Jien Kung
Hsing-Jien Kung
Tyrosine kinases play significant roles in tumor progression and therapy resistance. Inhibitors of tyrosine kinases are on the forefront of targeted therapy. For prostate cancer, tyrosine kinases play an additional role in the development o...