Maria Alexiadis,Natalie Eriksson,Stacey Jamieson et al.
Maria Alexiadis et al.
Granulosa cell tumors of the ovary (GCT) represent ~5% of malignant ovarian tumors. The adult form is defined by a mutation in the FOXL2 gene. GCT exhibit many of the features of normal proliferating granulosa cells. We have profiled the ex...
Testosterone regulates tight junction proteins and influences prostatic autoimmune responses [0.03%]
睾酮调节紧密连接蛋白并影响前列腺自身免疫反应
Jing Meng,Elahe A Mostaghel,Funda Vakar-Lopez et al.
Jing Meng et al.
Testosterone and inflammation have been linked to the development of common age-associated diseases affecting the prostate gland including prostate cancer, prostatitis, and benign prostatic hypertrophy. We hypothesized that testosterone reg...
Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation [0.03%]
芳香化酶抑制剂治疗后人类乳腺癌中5α-还原酶类型2表达增加及其与肿瘤细胞增殖降低的相关性研究
Niramol Chanplakorn,Pongsthorn Chanplakorn,Takashi Suzuki et al.
Niramol Chanplakorn et al.
Tumor cell proliferation and progression of breast cancer are influenced by female sex steroids. However, not all breast cancer patients respond to aromatase inhibitors (AI), and many patients become unresponsive or relapse. Recent studies ...
Randomized Controlled Trial
Hormones & cancer. 2011 Feb;2(1):73-81. DOI:10.1007/s12672-010-0062-2 2011
Prostate cancer stem cells: do they have a basal or luminal phenotype? [0.03%]
前列腺癌干细胞：它们是基底样表型还是腔上皮表型？
Norman J Maitland,Fiona M Frame,Euan S Polson et al.
Norman J Maitland et al.
The prostate is a luminal secretory tissue whose function is regulated by male sex hormones. Castration produces involution of the prostate to a reversible basal state, and as the majority of prostate cancers also have a luminal phenotype, ...
Jonathan J Li
Jonathan J Li
Expression and relevance of TRPS-1: a new GATA transcription factor in breast cancer [0.03%]
TRPS-1的表达及其在乳腺癌中的意义：一种新的GATA转录因子
Jie Qing Chen,Yi Bao,Jennifer Litton et al.
Jie Qing Chen et al.
GATA transcription factor family members have been found to play a critical role in the differentiation of many tissue types. For example, GATA-3 has been found to be highly correlated with estrogen receptor α (ER) expression and is emergi...
Discovery and validation of breast cancer early detection biomarkers in preclinical samples [0.03%]
乳腺癌早期诊断生物标志物的鉴定与验证（源自临床前样本）
Christopher I Li
Christopher I Li
Despite the widespread use of mammography for breast cancer screening, breast cancer remains the most common cause of cancer-related mortality among women worldwide. The identification of blood-based biomarkers useful for the early detectio...
Functional significance of Aurora kinase A regulatory interactions with p53-ERα complex in human breast cancer cells [0.03%]
乳腺癌细胞中Aurora激酶A与p53-雌激素受体α复合物相互作用的功能意义
Hiroshi Katayama,Subrata Sen
Hiroshi Katayama
Aurora kinase A (Aurora-A), a proto-oncogenic mitosis-regulating serine/threonine kinase, is frequently overexpressed in human breast cancer. While the kinase has been shown to cause functional inactivation of tumor suppressor protein p53, ...
Aberrant activation of cell cycle regulators, centrosome amplification, and mitotic defects [0.03%]
细胞周期调节物活化异常、中心体放大和有丝分裂缺陷
Kenji Fukasawa
Kenji Fukasawa
The centrosome that functions as a microtubule organizing center of a cell plays a key role in formation of bipolar mitotic spindles. Cells normally have either one (unduplicated) or two (duplicated) centrosomes. However, loss of the mechan...
Breast cancer stem cells and their role in resistance to endocrine therapy [0.03%]
乳腺癌干细胞及其在内分泌治疗抵抗中的作用
Ciara S O&#x;Brien,Gillian Farnie,Sacha J Howell et al.
Ciara S O&#x;Brien et al.
Developmentally, tumours can be viewed as aberrant versions of normal tissues. For example, tumours often retain differentiation markers of their tissue of origin. In addition, there is evidence that they contain cancer stem-like cells (CSC...