Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice [0.03%]
甘精胰岛素和NPH胰岛素以相似程度增加糖尿病小鼠结肠上皮细胞增殖和异常隐窝灶的形成
Jutta M Nagel,Jürgen Staffa,Ingrid Renner-Müller et al.
Jutta M Nagel et al.
The insulin analog glargine has a higher binding affinity than regular insulin for the insulin-like growth factor 1 receptor in vitro, raising questions about increased mitogenicity in vivo. Observational studies in humans have recently rep...
MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer [0.03%]
微RNA连接雌激素受体α状态和乳腺癌中的Dicer水平
Dawn R Cochrane,Diana M Cittelly,Erin N Howe et al.
Dawn R Cochrane et al.
To identify microRNAs (miRNAs) associated with estrogen receptor (ESR1) status, we profiled luminal A, ESR1+ breast cancer cell lines versus triple negative (TN), which lack ERα, progesterone receptor and Her2/neu. Although two thirds of t...
Chun-Peng Liao,Helty Adisetiyo,Mengmeng Liang et al.
Chun-Peng Liao et al.
For a study of interactions between the cancer-associated fibroblasts (CAFs) and the putative prostate cancer stem cells (CSCs), we used a conditional Pten deletion mouse model of prostatic adenocarcinoma to isolate both CAF cultures and CS...
Suppression of metastatic murine ovarian cancer cells by transduced embryonic progenitor cells [0.03%]
胚胎前体细胞转导后抑制小鼠卵巢癌细胞转移
Masaki Mandai,Junzo Hamanishi,Kaoru Abiko et al.
Masaki Mandai et al.
Ovarian cancer is the leading cause of death among gynecological malignancies. Chemotherapy alone is not sufficient to achieve long-term survival of the patient with advanced stage ovarian cancer. Although cancer immune therapy has long bee...
Antonio F Saad,Wei Hu,Anil K Sood
Antonio F Saad
Multiple genetic alterations play a role in the pathogenesis of ovarian cancer. Although many key proteins and pathways involved in ovarian carcinogenesis and metastasis have been discovered, knowledge of the early steps leading to malignan...
Christopher I Li
Christopher I Li
There are several histologic types of breast cancer that beyond their histopathologic differences have distinct clinical characteristics. However, it is unclear how histology is related to risk of mortality particularly when differences in ...
In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer [0.03%]
孕期接触双酚A或己烯雌酚可增加乳腺EZH2表达：一种环境内分泌干扰物通过表观遗传机制导致乳腺癌的途径
Leo F Doherty,Jason G Bromer,Yuping Zhou et al.
Leo F Doherty et al.
Diethylstilbestrol (DES) and bisphenol-A (BPA) are estrogen-like endocrine-disrupting chemicals that induce persistent epigenetic changes in the developing uterus. However, DES exposure in utero is also associated with an increased risk of ...
Sharon H Chou,Sofia Tseleni-Balafouta,Hyun-Seuk Moon et al.
Sharon H Chou et al.
Adiponectin has been proposed to be a mediator of obesity-associated malignancies and to have direct antineoplastic effects acting via adiponectin receptors AdipoR1 and AdipoR2. We describe herein the expression of AdipoR1 and AdipoR2 in se...
2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells [0.03%]
2-甲氧基雌二醇抑制乳腺癌细胞中孕酮依赖性组织因子的表达和活性
Marisol Quezada,Jorge Diaz,Soledad Henriquez et al.
Marisol Quezada et al.
2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol with antiangiogenic and antitumor properties, although its mechanisms of action remain unclear. Progestins in hormone replacement therapy increase the risk of breast can...
Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review [0.03%]
来曲唑治疗子宫内膜间质肉瘤复发1例及文献复习
Vonetta T Sylvestre,Charles J Dunton
Vonetta T Sylvestre
Endometrial stromal sarcomas are rare tumors that recur long after initial excision. We report a case of recurrent endometrial stromal sarcoma treated with the aromatase inhibitor letrozole and an overview of research completed to date. A 5...