Dual blockade of PKA and NF-κB inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis [0.03%]
PKA和NF-κB双重阻滞可抑制H2 relaxin介导的去势抵抗性前列腺癌亚系的生长并诱导其凋亡
Ruth L Vinall,Christopher M Mahaffey,Ryan R Davis et al.
Ruth L Vinall et al.
We previously demonstrated that H2 relaxin (RLN2) facilitates castrate-resistant (CR) growth of prostate cancer (CaP) cells through PI3K/Akt/β-catenin-mediated activation of the androgen receptor (AR) pathway. As inhibition of this pathway...
Novel approaches to quantify estradiol-induced loss of ERβ1 protein in older mouse ovarian surface epithelium: new tools to assess the role of ER protein subtypes in predisposing to ovarian epithelial cancer? [0.03%]
用于量化雌二醇诱导的老年小鼠卵巢表面上皮ERβ1蛋白丢失的新方法：评估ER蛋白亚型在易患卵巢上皮癌中的作用的新工具？
Linda S M Gulliver,Peter R Hurst
Linda S M Gulliver
Loss of estrogen receptor-beta (ERβ) occurs in ovarian epithelial cancer (OEC), a cancer of mainly older women. OEC is linked epidemiologically to hormone replacement therapy, predominantly with estrogen-only formulations. This study intro...
The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice [0.03%]
他莫昔芬和鱼油对多瘤中T转基因鼠乳腺癌发生的影响
Andrea Manni,Haifang Xu,Sharlene Washington et al.
Andrea Manni et al.
In these experiments, we tested the hypothesis that inhibition of the estrogen receptor (ER) with Tamoxifen and activation of PPARγ with fish oil (FO) rich in omega-3 (n-3; known PPAR agonists) inhibit the development of hormone-independen...
Dietary fat, fiber, and carbohydrate intake and endogenous hormone levels in premenopausal women [0.03%]
绝经前妇女的膳食脂肪、纤维和碳水化合物摄入与体内激素水平的关系
Xiaohui Cui,Bernard Rosner,Walter C Willett et al.
Xiaohui Cui et al.
The authors conducted a cross-sectional study to investigate the associations of fat, fiber, and carbohydrate intake with endogenous estrogen, androgen, and insulin-like growth factor (IGF) levels among 595 premenopausal women. Overall, no ...
Expression and in vitro functions of the ghrelin axis in endometrial cancer [0.03%]
胃泌素在子宫内膜癌中的表达及体外功能研究
Jenny N T Fung,Inge Seim,Dengfeng Wang et al.
Jenny N T Fung et al.
Ghrelin is a peptide hormone produced in the stomach and a range of other tissues, where it has endocrine, paracrine and autocrine roles in both normal and disease states. Ghrelin has been shown to be an important growth factor for a number...
Sujit Basu,Donald J Tindall
Sujit Basu
Prostate cancer represents a major health problem in men worldwide. Androgens are required for the growth and maintenance of the prostate. Androgens act by binding to the androgen receptor (AR), a nuclear receptor transcription factor prese...
Estrogen receptor alpha phosphorylated at tyrosine 537 is associated with poor clinical outcome in breast cancer patients treated with tamoxifen [0.03%]
雌激素受体α酪氨酸537磷酸化与乳腺癌患者他莫昔芬治疗预后不良有关
Georgios P Skliris,Zoann Nugent,Peter H Watson et al.
Georgios P Skliris et al.
A phospho-tyrosine 537-ERα (p-Y537-ERα) antibody was validated for immunohistochemistry of formalin-fixed paraffin-embedded human breast cancer biopsies and used to interrogate multiple ER positive breast cancer cases present on tissue mi...
CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas [0.03%]
CTNNB1基因突变、垂体转录因子以及MicroRNA表达在骨硬化性颅咽管瘤发病机制中的作用
Marina Lanciotti Campanini,Leandro Machado Colli,Beatriz Maria Carvalho Paixao et al.
Marina Lanciotti Campanini et al.
Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis. The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, ...
Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin? [0.03%]
基因表达谱分析揭示鸡卵巢癌差异表达的基因：支持卵管起源说？
Lindsey S Treviño,James R Giles,Wei Wang et al.
Lindsey S Treviño et al.
Ovarian cancer has a high mortality rate due, in part, to the lack of early detection and incomplete understanding of the origin of the disease. The hen is the only spontaneous model of ovarian cancer and can therefore aid in the identifica...
Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events [0.03%]
卵巢癌细胞中的膜孕酮受体(mPR/PAQR)表达及其介导的孕酮信号事件
Nathan J Charles,Peter Thomas,Carol A Lange
Nathan J Charles
The high mortality rates associated with ovarian cancer are largely due to a lack of highly effective treatment options for advanced stage disease; a time when initial diagnosis most commonly occurs. Recent evidence suggests that the steroi...