FDG PET in the management of patients with adrenal masses and adrenocortical carcinoma [0.03%]
肾上腺肿瘤和肾上腺皮质癌患者的18F-FDG PET检查
Désirée Deandreis,Sophie Leboulleux,Caroline Caramella et al.
Désirée Deandreis et al.
Adrenocortical carcinoma (ACC) is a rare tumor with aggressive behavior, high recurrence rate, and rapid evolution. Surgery is the only curative modality, while systemic treatments such as mitotane and chemotherapy associated to locoregiona...
Estrogen receptor-beta mediates the protective effects of aromatase induction in the MMTV-Her-2/neu x aromatase double transgenic mice [0.03%]
雌二醇受体介导了在MMTV-Her-2 / neu ×芳香化酶双重转基因小鼠中的芳香化酶诱导的保护作用-beta
Hareesh B Nair,Rao P Perla,Nameer B Kirma et al.
Hareesh B Nair et al.
Breast cancers amplified for the tyrosine kinase receptor Her-2/neu constitute ~30% of advanced breast cancer cases, and are characterized by hormone independence and aggressive growth, implicating this pathway in breast oncogenesis. The in...
Conventional imaging in adrenocortical carcinoma: update and perspectives [0.03%]
肾上腺皮质癌的常规影像学检查：更新与展望
William F Young Jr
William F Young Jr
The objectives of this study were to review how conventional imaging for adrenocortical carcinoma has evolved over the past 100 years and to highlight the current role for computed tomography (CT) and magnetic resonance imaging (MRI). Using...
The Weiss score and beyond--histopathology for adrenocortical carcinoma [0.03%]
维斯评分之外——肾上腺皮质癌的组织病理学研究
Mauro Papotti,Rossella Libè,Eleonora Duregon et al.
Mauro Papotti et al.
The pathological diagnosis of adrenocortical carcinoma (ACC) is still challenging for its rarity and the presence of special variants (pediatric, oncocytic, myxoid, and sarcomatoid). It is based on the recognition at light microscopy of at ...
Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene [0.03%]
ESR2基因启动子多态性功能表征
Santosh Philips,Alexandra Richter,Steffi Oesterreich et al.
Santosh Philips et al.
The ESR2 gene encodes the estrogen receptor beta protein. Several studies have shown that genetic variants in the ESR2 gene are associated with a variety of clinical phenotypes. However, very little is known about the functional significanc...
Alfredo Berruti,Paola Sperone,Elisa Bellini et al.
Alfredo Berruti et al.
Metronomic chemotherapy is the administration of cytotoxic drugs at low doses, on a frequent or continuous schedule, with no extended interruption. This treatment approach can target tumor cells indirectly since it can affect the endotheliu...
PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures [0.03%]
PI3K和Erk信号通路在BMP7诱导的PC-3前列腺癌细胞上皮间质转化中的作用：二维和三维培养体系的研究
Minyoung Lim,Cheng-Ming Chuong,Pradip Roy-Burman
Minyoung Lim
We reported previously that bone morphogenetic protein 7 (BMP7) could induce epithelial-mesenchymal transition (EMT) in PC-3 prostate cancer cells grown in tissue culture plates. In this study, we examined BMP7-induced morphological and mol...
FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer [0.03%]
FOXP1通过调控乳腺癌细胞增殖影响他莫昔芬治疗乳腺癌患者的五年无病生存率
Takashi Shigekawa,Nobuhiro Ijichi,Kazuhiro Ikeda et al.
Takashi Shigekawa et al.
Breast cancer is primarily a hormone-dependent tumor that can be regulated by the status of steroid hormones, including estrogen and progesterone. Forkhead box P1 (FOXP1) is a member of the forkhead box transcription factor family and has b...
A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D [0.03%]
氯喹和维生素D通过在乳腺肿瘤细胞中切换自噬类型以达到放射增敏作用
Eden N Wilson,Molly L Bristol,Xu Di et al.
Eden N Wilson et al.
Calcitriol or 1,25-dihydroxyvitamin D3, the hormonally active form of vitamin D, as well as vitamin D analogs, has been shown to increase sensitivity to ionizing radiation in breast tumor cells. The current studies indicate that the combina...
A five-gene model predicts clinical outcome in ER+/PR+, early-stage breast cancers treated with adjuvant tamoxifen [0.03%]
五个基因模型可预测雌激素受体阳性/孕激素受体阳性、早期乳腺癌患者的他莫昔芬辅助治疗效果
Daniel Alan Kerr nd,James L Wittliff
Daniel Alan Kerr nd
Primary breast carcinomas expressing both estrogen and progesterone receptors are most likely to respond to tamoxifen therapy, especially in patients with early-stage lesions. However, certain patients exhibit clinicopathologic features sug...