Effects of oestrogen on microRNA expression in hormone-responsive breast cancer cells [0.03%]
雌激素对激素反应性乳腺癌细胞中微小核糖核酸表达的影响
Lorenzo Ferraro,Maria Ravo,Giovanni Nassa et al.
Lorenzo Ferraro et al.
Oestrogen receptor alpha (ERα) is a ligand-dependent transcription factor that mediates oestrogen effects in hormone-responsive cells. Following oestrogenic activation, ERα directly regulates the transcription of target genes via DNA bind...
Frequent germ-line mutations of the MEN1, CASR, and HRPT2/CDC73 genes in young patients with clinically non-familial primary hyperparathyroidism [0.03%]
MEN1、CASR和HRPT2/CDC73基因在年轻不具有家族史原发性甲状旁腺功能亢进症患者中发生频繁的遗传变异
Lee F Starker,Tobias Akerström,William D Long et al.
Lee F Starker et al.
Familial primary hyperparathyroidism (FPHPT) may occur due to an underlying germ-line mutation in the MEN1, CASR, or HRPT2/CDC73 genes. The disease may be undiagnosed in the absence of a history suggestive of FHPT. Young PHPT patients (≤45...
Gary D Hammer,Martin Fassnacht,Enzo Lalli
Gary D Hammer
Steroid profiling by gas chromatography-mass spectrometry and high performance liquid chromatography-mass spectrometry for adrenal diseases [0.03%]
气相色谱-质谱法和高效液相色谱-质谱法肾上腺疾病皮质醇类固醇谱分析
Jeffrey G McDonald,Susan Matthew,Richard J Auchus
Jeffrey G McDonald
The ability to measure steroid hormone concentrations in blood and urine specimens is central to the diagnosis and proper treatment of adrenal diseases. The traditional approach has been to assay each steroid hormone, precursor, or metaboli...
Michael J Demeure,Kimberly J Bussey,Lawrence S Kirschner
Michael J Demeure
Standard chemotherapy for adrenocortical cancer currently is under evaluation in the context of the recently completed FIRM-ACT evaluating the combination of mitotane with either streptozocin or etoposide, cisplatin, and doxorubicin. New ag...
Therapeutic management of advanced adrenocortical carcinoma: what do we know in 2011? [0.03%]
2011年关于肾上腺皮质癌的治疗管理我们知道了多少？
E Baudin,S Leboulleux,A Al Ghuzlan et al.
E Baudin et al.
The prognosis of advanced adrenocortical carcinoma (ACC) is dismal but heterogeneous. In 2011, mitotane is the only drug approved in Europe and US for the treatment of advanced ACC. Mitotane exerts both antisecretory and antiproliferative e...
Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression [0.03%]
乳腺癌进展中HGF/Met信号转导对Brk和Sam68的作用机制研究
Alessia Locatelli,Kristopher A Lofgren,Andrea R Daniel et al.
Alessia Locatelli et al.
Signal transduction pathways downstream of receptor tyrosine kinases (RTKs) are often deregulated during oncogenesis, tumor progression, and metastasis. In particular, the peptide growth factor hormone, hepatocyte growth factor (HGF), and i...
Beyond castration-defining future directions in the hormonal treatment of prostate cancer [0.03%]
去势之外：前列腺癌内分泌治疗未来发展方向
Saroj Niraula,Kim Chi,Anthony Michael Joshua
Saroj Niraula
It is now almost 70 years since Charles Huggins described the relationship between testosterone and the prostate gland. Arguably defining one of the first targeted therapies, the reduction of testosterone to castrate levels remains unaltere...
A debate on laparoscopic versus open adrenalectomy for adrenocortical carcinoma [0.03%]
后腹腔镜与开放手术治疗肾上腺皮质癌的争论
Francesco Porpiglia,Barbra S Miller,Matteo Manfredi et al.
Francesco Porpiglia et al.
Adrenocortical cancer (ACC) is a rare disease that is difficult to treat. Surgery remains the primary treatment modality and the only chance for cure in these patients. Since the early 1990s, laparoscopic adrenalectomy (LA) has replaced ope...
S Hahner,A Sundin
S Hahner
Due to broader use of conventional imaging techniques, adrenal tumors are detected with increasing frequency comprising a wide variety of different tumor entities. Despite improved conventional imaging techniques, a significant number of ad...