Extended RET gene analysis in patients with apparently sporadic medullary thyroid cancer: clinical benefits and cost [0.03%]
对散发性甲状腺髓样癌患者的RET基因扩展分析：临床效益和费用
Susan C Lindsey,Ilda S Kunii,Fausto Germano-Neto et al.
Susan C Lindsey et al.
RET sequencing has become an important tool in medullary thyroid cancer (MTC) evaluation and should be performed even in the absence of family history of MTC. The most commonly studied exons in index cases are 8, 10, 11, and 13-16. To addre...
Somatic mutation analysis of the SDHB, SDHC, SDHD, and RET genes in the clinical assessment of sporadic and hereditary pheochromocytoma [0.03%]
SDHB、SDHC、SDHD和RET基因体细胞突变分析在散发性和遗传性嗜铬细胞瘤临床评估中的作用
Alexander Weber,Michael M Hoffmann,Hartmut P H Neumann et al.
Alexander Weber et al.
Systemic analysis of somatic mutations of other susceptibility genes in syndromic tumors as well as apparently sporadic tumors in well-characterized specimens is lacking. Its clinical relevance has not been studied. Our objective was to det...
Apigenin induces apoptosis and blocks growth of medroxyprogesterone acetate-dependent BT-474 xenograft tumors [0.03%]
阿普菲宁可诱导类固醇抗性BT-474异种移植物的凋亡并阻断其生长
Benford Mafuvadze,Yayun Liang,Cynthia Besch-Williford et al.
Benford Mafuvadze et al.
Recent clinical and epidemiological evidence shows that hormone replacement therapy (HRT) containing both estrogen and progestin increases the risk of primary and metastatic breast cancer in post-menopausal women while HRT containing only e...
Systematic review and meta-analysis of insulin therapy and risk of cancer [0.03%]
系统评价和荟萃分析：胰岛素治疗与癌症风险的关系
Mohsen Janghorbani,Mohsen Dehghani,Mohammad Salehi-Marzijarani
Mohsen Janghorbani
Recent epidemiological studies suggest that treatment with insulin may promote cancer growth. The present systematic review and meta-analysis of published observational studies was conducted to assess the risk of cancer during treatment wit...
Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients [0.03%]
双阳性FOXA1和FOXP1免疫反应与他莫昔芬治疗的乳腺癌患者有利预后相关性分析
Nobuhiro Ijichi,Takashi Shigekawa,Kazuhiro Ikeda et al.
Nobuhiro Ijichi et al.
Breast cancer is primarily a hormone-dependent tumor that can be regulated by the status of the steroid hormones estrogen and progesterone. Forkhead box A1 (FOXA1) is a member of the forkhead box transcription factor family and functions as...
Growth hormone-releasing hormone receptor splice variant 1 is frequently expressed in oral squamous cell carcinomas [0.03%]
生长激素释放激素受体剪接变异型1在舌鳞状细胞癌中的表达分布及其临床意义研究
Nikolina Dioufa,Elena Farmaki,Andrew V Schally et al.
Nikolina Dioufa et al.
The expression of growth hormone-releasing hormone (GHRH) splice variant 1 (SV1) receptor in neoplastic lesions of the oral cavity was assessed. The sensitivity of HaCaT keratinocytes to GHRH analogs was also evaluated. Thirty-three benign ...
Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors [0.03%]
雄性激素抗性可增加雌性小鼠DMBA诱导的乳腺肿瘤易感性
Ulla Simanainen,Yan Ru Gao,Kirsty A Walters et al.
Ulla Simanainen et al.
Hormones, notably estrogens, are pivotal in the origins of breast cancer but androgenic effects, while supported by persistence of AR expression in breast cancers, remain controversial. This study determined the role of the androgen actions...
Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors [0.03%]
膜孕酮受体（mPR）介导乳腺癌细胞中的孕酮诱导的抗肿瘤作用并在人乳腺肿瘤中表达
Gwen E Dressing,Rebecca Alyea,Yefei Pang et al.
Gwen E Dressing et al.
Membrane progesterone receptors (mPRs) have been detected in breast cancer cells and tissues, but their roles in cancer progression remain unclear. Here, we demonstrate the localization, signaling, and antiapoptotic actions of mPRs in two n...
Glucocorticoids regulate gene expression and repress cellular proliferation in human uterine leiomyoma cells [0.03%]
糖皮质激素调节人类子宫平滑肌瘤细胞的基因表达和抑制细胞增殖
Shannon Whirledge,Darlene Dixon,John A Cidlowski
Shannon Whirledge
Sex hormones and growth factors have been implicated in the pathogenesis of uterine leiomyomas. The uterus is also an abundant source of the glucocorticoid receptor but its role and function have been largely ignored. Human samples of uteri...
Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer [0.03%]
雌激素受体beta在早期与晚期非小细胞肺癌中的不同作用
Sri Navaratnam,Georgios Skliris,Gefei Qing et al.
Sri Navaratnam et al.
Although women have an increased susceptibility to lung cancer, they also have a favorable clinical outcome. This may in part be due to female specific genetic and hormonal factors. In the present study, expression of ER-beta was investigat...