Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma [0.03%]
男性乳腺癌和女性乳腺癌肿瘤内的雌二醇浓度及诱导基因表达的比较研究
Kiyoshi Takagi,Takuya Moriya,Masafumi Kurosumi et al.
Kiyoshi Takagi et al.
It is speculated that estrogens play important roles in the male breast carcinoma (MBC) as well as the female breast carcinoma (FBC). However, estrogen concentrations or molecular features of estrogen actions have not been reported in MBC, ...
Comparative Study
Hormones & cancer. 2013 Feb;4(1):1-11. DOI:10.1007/s12672-012-0126-6 2013
Sang-Hyuk Chung,Myeong Kyun Shin,Kenneth S Korach et al.
Sang-Hyuk Chung et al.
The major etiological factor for cervical cancer is the high-risk human papillomavirus (HPV), which encodes E6 and E7 oncogenes. However, HPV is not sufficient, and estrogen has been proposed as an etiological cofactor for the disease. Its ...
IGFBP-3 nuclear localization predicts human prostate cancer recurrence [0.03%]
IGFBP-3核定位用于预测人类前列腺癌复发
David B Seligson,Hong Yu,Sheila Tze et al.
David B Seligson et al.
Insulin-like growth factor binding protein-3 (IGFBP-3) is a pro-apoptotic, anti-metastasic, and anti-angiogenic protein. Low serum IGFBP-3 has been associated with risk of more aggressive prostate cancer (PCa). We investigated the impact of...
Body size in relation to urinary estrogens and estrogen metabolites (EM) among premenopausal women during the luteal phase [0.03%]
黄体期前绝经妇女身体质量与尿雌激素及雌激素代谢物关系的研究
Jing Xie,A Heather Eliassen,Xia Xu et al.
Jing Xie et al.
Estrogen metabolism profiles may play an important role in the relationship between body size and breast carcinogenesis. Previously, we observed inverse associations between current body mass index (BMI) and plasma levels of parent estrogen...
Medullary thyroid cancer--current treatment strategy, novel therapies and perspectives for the future [0.03%]
髓样甲状腺癌的治疗策略、新疗法及未来展望
Masahiro Sugawara,Tran Ly,Jerome M Hershman
Masahiro Sugawara
Medullary thyroid cancer (MTC), an uncommon and slow-growing tumor, is difficult to eradicate when metastasis or recurrence develops. This review describes therapeutic approaches to patients with recurrent sporadic MTC, management of advanc...
Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant [0.03%]
ERΔ3转基因小鼠中宁诱导的乳腺癌基因发生抑制作用研究
Vicki L Davis,Firdos Shaikh,Katie M Gallagher et al.
Vicki L Davis et al.
The estrogen receptor α (ERα) splicing variant with an in-frame deletion of exon 3 (ERΔ3) is frequently expressed in the normal breast, but its influence on tumorigenesis has not been explored. In vitro, ERΔ3 has dominant negative activ...
Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation [0.03%]
雷洛昔芬通过雌激素受体依赖性诱导凋亡和抑制增殖来抑制RT4尿路上皮癌细胞的生长
Kristi L Hoffman,Seth P Lerner,Carolyn L Smith
Kristi L Hoffman
Bladder cancer is the fifth most common type of cancer in the USA, with over 70,000 new cases diagnosed each year. Treatment often involves invasive surgical therapies, as chemotherapy alone is often ineffective and associated with high rec...
Effects of omega-3 fatty acids on progestin stimulation of invasive properties in breast cancer [0.03%]
欧米伽-3脂肪酸对孕酮刺激乳腺癌侵袭特性的影响
Michael R Moore,Rebecca A King
Michael R Moore
Clinical studies have shown that progestins increase breast cancer risk in hormone replacement therapy, while we and others have previously reported that progestins stimulate invasive properties in progesterone receptor (PR)-rich human brea...
Migraine history, nonsteroidal anti-inflammatory drug use, and risk of postmenopausal endometrial cancer [0.03%]
偏头痛史、非甾体抗炎药使用与绝经后子宫内膜癌风险的关系
Amanda I Phipps,Garnet L Anderson,Barbara B Cochrane et al.
Amanda I Phipps et al.
Endometrial cancer is primarily a hormonally mediated disease. As such, factors that mediate or reflect exposure to estrogens, or that mediate response to such exposure, may plausibly be associated with endometrial cancer risk. History of m...
Multicenter Study
Hormones & cancer. 2012 Dec;3(5-6):240-8. DOI:10.1007/s12672-012-0117-7 2012
The Cancer BioChip System: a functional genomic assay for anchorage-independent three-dimensional breast cancer cell growth [0.03%]
癌细胞芯片系统：评估乳腺癌细胞悬液培养的功能基因组筛选实验平台
Rula A Abbud-Antaki,Joie N Marhefka,Aimee L DeLuca et al.
Rula A Abbud-Antaki et al.
Advances in genomic research have revealed that each patient has their own unique tumor profile. While silencing RNA (siRNA) screening tests can identify which genes drive tumor cell growth, results obtained from these assays have been limi...