Advanced Adrenocortical Carcinoma (ACC): a Review with Focus on Second-Line Therapies [0.03%]
晚期肾上腺皮质癌（ACC）的综述及二线治疗:focus
Luke Ardolino,Aaron Hansen,Stephen Ackland et al.
Luke Ardolino et al.
Advanced adrenocortical cancer (ACC) is a rare, highly aggressive malignancy, which typically has a poor prognosis. In advanced ACC, the overall trend is toward a short PFS interval following first-line systemic therapy, highlighting a clea...
TSH Level and Risk of Malignancy in Patients with Bethesda Category IV Thyroid Nodules [0.03%]
促甲状腺激素水平与bethesdaIV类甲状腺结节恶性风险的关系研究
Carolina Fernández-Trujillo,Julio Pérez-Zaballos,Carlos A Rodríguez-Pérez et al.
Carolina Fernández-Trujillo et al.
Fine needle aspiration biopsy does not permit to distinguish between benign and malignant follicular thyroid lesions (category IV in the Bethesda Cytopathology System). Some reports have suggested an association between increased serum TSH ...
Lack of Mutations in POT1 Gene in Selected Families with Familial Non-Medullary Thyroid Cancer [0.03%]
选择家庭中POT1基因不在家族性非髓样甲状腺癌中的突变
Aida Orois,Celia Badenas,Jordi L Reverter et al.
Aida Orois et al.
To date, the genes involved in familial non-medullary thyroid cancer (FNMTC) remain poorly understood, with the exception of syndromic cases of FNMTC. It has been proposed that germline mutations in telomere-related genes, such as POT1, des...
Multicenter Study
Hormones & cancer. 2020 Apr;11(2):111-116. DOI:10.1007/s12672-020-00383-5 2020
Baicalein Is a Phytohormone that Signals Through the Progesterone and Glucocorticoid Receptors [0.03%]
黄酮类化合物 baicalein 通过孕激素和糖皮质激素受体传递信号
Julia R Austin,Brenna J Kirkpatrick,Rocío Rivera Rodríguez et al.
Julia R Austin et al.
While flavonoids have been studied extensively for estrogen receptor activity, they have not been well studied for their ability to modify progesterone receptor (PR) and glucocorticoid receptor (GR) signaling. Three flavonoid compounds, tan...
The Role of mPRδ and mPRε in Human Glioblastoma Cells: Expression, Hormonal Regulation, and Possible Clinical Outcome [0.03%]
mPRδ和mPRε在人胶质母细胞瘤细胞中的作用：表达、激素调节及可能的临床意义
Aylin Del Moral-Morales,Juan Carlos González-Orozco,José Moisés Capetillo-Velázquez et al.
Aylin Del Moral-Morales et al.
Glioblastomas (GBM) are the most frequent and aggressive primary tumor of the central nervous system. In recent years, it has been proposed that sex hormones such as progesterone play an essential role in GBM biology. Membrane progesterone ...
Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells [0.03%]
雌激素通过ERα阳性乳腺癌细胞中PELP1介导的质膜起始信号诱导MMP-9表达
Yu Pan,Xiuli Wang,Yanzhi Zhang et al.
Yu Pan et al.
Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERα coregulators, and has been suggested to be involved in metastasis of several cancers...
Neeraja Sathyamoorthy,Carol A Lange
Neeraja Sathyamoorthy
Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines [0.03%]
小鼠乳腺癌细胞系中胞浆型ERα和NFκB促进细胞存活
Emily Smart,Luis H Alejo,Jonna Frasor
Emily Smart
There is a desperate need in the field for mouse mammary tumors and cell lines that faithfully mimic estrogen receptor (ER) expression and activity found in human breast cancers. We found that several mouse mammary cancer cell lines express...
Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism [0.03%]
双侧肾上腺醛固酮增多症的ATP2B4基因变异的分子及电生理学分析
Namita Ganesh Hattangady,Jessica Foster,Antonio Marcondes Lerario et al.
Namita Ganesh Hattangady et al.
Primary aldosteronism (PA) is the most common cause of secondary hypertension with a high prevalence among patients with resistant hypertension. Despite the recent discovery of somatic variants in aldosterone-producing adenoma (APA)-associa...
Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer [0.03%]
转移性雌激素受体阳性乳腺癌中的孕激素受体基因变异
Amy M Fowler,Kelley Salem,Michael DeGrave et al.
Amy M Fowler et al.
Tumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the pr...