Interferon-alpha Treatment for Disease Control in Metastatic Pheochromocytoma/Paraganglioma Patients [0.03%]
干扰素-α治疗转移性嗜铬细胞瘤/副神经节瘤患者的疗效分析
Julien Hadoux,Marie Terroir,Sophie Leboulleux et al.
Julien Hadoux et al.
Interferon-alpha (IFN-alpha) is recommended in neuroendocrine tumors (NET). Malignant pheochromocytoma and paragangliomas (MPPGLs) constitute a rare subgroup of NET with few treatment options. IFN-alpha efficacy in patients with MPPGLs was ...
The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer [0.03%]
雄激素受体在肥胖和乳腺癌的临床前模型中卵巢功能丧失后支持肿瘤进展
Elizabeth A Wellberg,L Allyson Checkley,Erin D Giles et al.
Elizabeth A Wellberg et al.
The androgen receptor (AR) has context-dependent roles in breast cancer growth and progression. Overall, high tumor AR levels predict a favorable patient outcome, but several studies have established a tumor promotional role for AR, particu...
Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells [0.03%]
二十碳四烯酸在前列腺癌细胞存活中的作用
Cecilia Colombero,Daniela Papademetrio,Paula Sacca et al.
Cecilia Colombero et al.
20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the ω-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2). 20-HETE induces mitogenic responses in different cancer cells. T...
The Complex Biology of the Aryl Hydrocarbon Receptor and Its Role in the Pituitary Gland [0.03%]
芳烃受体的复杂生物学及其在垂体中的作用
Robert Formosa,Josanne Vassallo
Robert Formosa
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydro...
Estrogen Receptor-β Modulation of the ERα-p53 Loop Regulating Gene Expression, Proliferation, and Apoptosis in Breast Cancer [0.03%]
雌激素受体-β调节的ERα-p53信号环在乳腺癌基因表达、增殖和凋亡中的作用研究
Wenwen Lu,Benita S Katzenellenbogen
Wenwen Lu
Estrogen receptor α (ERα) is a crucial transcriptional regulator in breast cancer, but estrogens mediate their effects through two estrogen receptors, ERα and ERβ, subtypes that have contrasting regulatory actions on gene expression and...
Acquired Tamoxifen Resistance in MCF-7 Breast Cancer Cells Requires Hyperactivation of eIF4F-Mediated Translation [0.03%]
获得性他莫昔芬耐药的MCF-7乳腺癌细胞需要eIF4F介导的翻译过度活化
Dedra H Fagan,Lynsey M Fettig,Svetlana Avdulov et al.
Dedra H Fagan et al.
While selective estrogen receptor modulators, such as tamoxifen, have contributed to increased survival in patients with hormone receptor-positive breast cancer, the development of resistance to these therapies has led to the need to invest...
Alcohol Intake and Risk of Breast Cancer by Histologic Subtype and Estrogen Receptor Status Among Women Aged 55 to 74 Years [0.03%]
饮酒与绝经后妇女按病理分型和雌激素受体状态的乳腺癌风险：基于55至74岁女性的研究
Michelle L Baglia,Kathleen E Malone,Mei-Tzu C Tang et al.
Michelle L Baglia et al.
Previous studies suggest that alcohol consumption and risk of breast cancer may differ by histologic subtype and hormone receptor status, though results are not entirely consistent. In this population-based case-control study, we evaluated ...
Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6 [0.03%]
潘伯诺statin通过增加黄体生成素受体和诱发基因-6增强孕激素对子宫内膜癌的生长抑制作用
Hirofumi Ando,Tsutomu Miyamoto,Hiroyasu Kashima et al.
Hirofumi Ando et al.
Although progestin has been used to treat endometrial hyperplasia and endometrial carcinoma (EC), its therapeutic efficacy is limited. In order to improve this, the underlining mechanisms of the effects of progestin need to be elucidated in...
Nanoparticulate Tetrac Inhibits Growth and Vascularity of Glioblastoma Xenografts [0.03%]
纳米颗粒状四乙酸血红素抑制胶质母细胞瘤移植肿瘤的生长和血管生成
Thangirala Sudha,Dhruba J Bharali,Stewart Sell et al.
Thangirala Sudha et al.
Thyroid hormone as L-thyroxine (T4) stimulates proliferation of glioma cells in vitro and medical induction of hypothyroidism slows clinical growth of glioblastoma multiforme (GBM). The proliferative action of T4 on glioma cells is initiate...
A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy [0.03%]
一种新颖的联合靶向雌激素受体和核因子κB途径治疗乳腺癌的方法
Irida Kastrati,Marton I Siklos,Svitlana D Brovkovych et al.
Irida Kastrati et al.
Nearly 75% of breast tumors express estrogen receptor (ER), and will be treated with endocrine therapy, such as selective estrogen receptor modulator (SERM), tamoxifen, or aromatase inhibitors. Despite their proven success, as many as 40-50...