Identification of Ischemic Stroke Patients Based on Plasma Concentrations of Extracellular Vesicles [0.03%]
基于血浆外泌体浓度的缺血性卒中患者识别
Naomi C Buntsma,Chi M Hau,Mandy Los et al.
Naomi C Buntsma et al.
Patients presenting with stroke symptoms suffer from either ischemic stroke, hemorrhagic stroke, transient ischemic attacks (TIA), or "stroke mimics," which include benign headaches, epilepsy, and vestibular disorders. As ischemic and hemor...
Astrocyte-derived Exosomal GJA1-20 k Targets Pink1-mediated Mitophagy to Attenuate Traumatic Brain Injury [0.03%]
星形胶质细胞源外泌体GJA1-20k通过靶向Pink1介导的线粒体自噬减轻创伤性脑损伤
Yalun Li,Wei Chen,Jiugeng Feng
Yalun Li
Connexin 43 (Cx43), particularly its truncated isoform GJA1-20 k, has shown promise in mitigating neuronal injury through mitochondrial regulation. This study aimed to investigate the therapeutic potential of astrocyte-derived extracellular...
Exploring the Association Between Early PaCO2 Correction Speed and Cerebrovascular Autoregulation in a Porcine Model of Extracorporeal Resuscitation [0.03%]
探索早期纠酸速度与体外心肺复苏后脑血管自主调节恢复的关系：猪模型研究
Mingfeng Cao,Camila S Contreras-Rojas,Qihong Wang et al.
Mingfeng Cao et al.
Background: Prior clinical research demonstrated that rapid reduction in arterial carbon dioxide (PaCO2) levels during extracorporeal membrane oxygenation (ECMO) is associated with acute brain injury (ABI), which may be d...
Comprehensive Venous Outflow Evaluation Predicts Stroke Outcome After Optimal Endovascular Ischemic Stroke Treatment [0.03%]
最佳血管内缺血性卒中治疗后的全面静脉回流评估可以预测卒中结局
Francesco Favruzzo,Lorena Nico,Alvise Fattorello Salimbeni et al.
Francesco Favruzzo et al.
Large vessel occlusion (LVO) acute ischemic stroke represents a leading cause of disability despite successful endovascular treatment (EVT). Venous outflow has recently emerged as a potential predictor of functional outcome in ischemic stro...
Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting [0.03%]
人尿激酶制剂联合治疗可改善前循环支架置入的认知和血流动力学结局
Liuting Hu,Fan Yang,Wenjin Shang et al.
Liuting Hu et al.
Chronic cerebral hypoperfusion due to anterior circulation stenosis contributes to cognitive decline. This study examined whether preoperative human urinary kallidinogenase (HUK) administration improves outcomes following percutaneous trans...
Serum Metabolome Profiling Reveals Biomarkers to Predict Malignant Brain Edema Following Endovascular Stroke Therapy [0.03%]
血清代谢组学揭示内血管性脑卒中治疗后恶性脑水肿预测生物标志物
Jiaqi Luo,Xiaolin Zhao,Mengxuan Xiao et al.
Jiaqi Luo et al.
Metabolomics reflects the body's metabolic state and holds substantial promise for identifying associated biomarkers and exploring pathological processes. This study used serum metabolomics to predict malignant brain edema (MBE) following e...
High Plasma Sarcosine Levels Are Associated with Decreased Risks of Adverse Outcomes After Ischemic Stroke: A Multicenter Prospective Study [0.03%]
血浆甜菜碱水平与缺血性卒中预后的关系：一项前瞻性多中心研究
Lulu Sun,Daoxia Guo,Xinyue Chang et al.
Lulu Sun et al.
Sarcosine has been reported to improve ischemic tolerance in animal models of brain ischemia, but population-based evidence from patients with ischemic stroke is lacking. We conducted a multicenter prospective study to investigate the assoc...
FLT1 as a Protective Factor in Ischemic Stroke: Insights from Real-World Pharmacovigilance and Genetic Evidence [0.03%]
来自真实世界药物警戒和遗传证据的FLT1缺血性卒中的保护因素
Haohao Chen,Jinhua Yang,Zihao Li et al.
Haohao Chen et al.
Ischemic stroke contributes substantially to global death and disability, yet effective molecular targets remain scarce. This study integrates real-world pharmacovigilance data, molecular databases, and genetic evidence to support the disco...
Modified Intracranial Aneurysm Rupture Rat Model with Angiographic Imaging [0.03%]
可进行血管造影成像的颅内动脉瘤破裂改良 rat 模型
William Wei-Lin Pan,Masahiko Itani,Kostadin Karagiozov et al.
William Wei-Lin Pan et al.
Intracranial aneurysms (IAs) are a major cause of spontaneous subarachnoid hemorrhage (SAH) and are associated with high morbidity and mortality. Current IA rodent models often exhibit low rupture rates and limited imaging capabilities, res...
Gamma-Benzylidene Digoxin Derivative Attenuates Neurotoxicity Response in a Murine Stroke Model [0.03%]
γ-苯并伊利地毒毛旋花子苷衍生物通过鼠脑卒中模型神经毒性反应评估其效力大小
Bruno de Souza Gonçalves,Carla P Dos Santos,Matheus V Machado et al.
Bruno de Souza Gonçalves et al.
Stroke is a prevalent age-related disease globally, contributing significantly to neurological dysfunction, disability, and mortality rates. Despite its substantial healthcare burden, effective therapies remain limited. Na/K-ATPase (NKA), b...