Internal Capsule Involvement Explains the Prognostic Impact of ASPECTS after Endovascular Thrombectomy for Large-Core Infarction [0.03%]
梗死核心体积较大缺血卒中行血管内治疗后，ASPECTS评分的预后影响由脑内小囊状占位解释
Kyubong Lee,Woochan Choi,Yang-Ha Hwang et al.
Kyubong Lee et al.
The prognostic implications of Alberta Stroke Program Early CT Score (ASPECTS) subscores in patients with large-core ischemic stroke undergoing endovascular thrombectomy (EVT) remain uncertain. We hypothesized that specific ASPECTS regions ...
Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cells Promote Functional Recovery after Experimental Intracerebral Hemorrhage Via Local and Systemic Immunomodulation [0.03%]
人脐带间充质干细胞的静脉输注通过局部和全身免疫调节促进实验性脑出血后功能恢复
Shoichiro Tsuji,Yoji Kuramoto,Yuki Takeda et al.
Shoichiro Tsuji et al.
Intracerebral hemorrhage (ICH) is associated with high mortality and disability, and current treatments offer limited benefits for functional recovery. Human umbilical cord-derived mesenchymal stromal cell (hUCMSC) have strong proliferative...
The Hyperacute Phase of Cerebral Infarction in a Swine Model Investigated with Cone-Beam CT Perfusion Imaging [0.03%]
锥形束CT灌注成像在猪脑梗死超急性期的动物实验研究
Gota Nagayama,Hirokazu Koseki,Ayako Ikemura et al.
Gota Nagayama et al.
In the clinical practice, patients hospitalized within 60 minutes from onset of stroke are rarely seen. This study investigated this phase in a swine middle cerebral artery (MCA) occlusion model using cone-beam CT perfusion imaging. Seven s...
Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside [0.03%]
缺血性脑卒中治疗中针对DNA损伤修复通路的靶点：从实验到临床
Zixian Xie,Yumin Luo,Ziping Han
Zixian Xie
Despite advances in reperfusion therapies following cerebral ischemic stroke, effective treatment options remain limited, and achieving optimal outcomes post-revascularization continues to be a significant challenge. Increasing evidences ha...
Transauricular Vagus Nerve Stimulation in Acute Ischaemic Stroke Requiring Mechanical Thrombectomy: Sham-Controlled, Randomised Device Trial [0.03%]
急性缺血性脑卒中机械取栓患者的耳后迷走神经刺激治疗：假手术对照随机装置试验
Gareth L Ackland,David Crane,Sanjali Ahuja et al.
Gareth L Ackland et al.
Autonomic dysfunction leads to hemodynamic instability and immunosuppression after ischaemic stroke, and is independently associated with worse outcomes. We hypothesized that non-invasive peripheral neuromodulation, using transcutaneous aur...
Development and Validation of an Interpretable Hemodynamics-Based Machine Learning Model for Predicting Cerebral Arteriovenous Malformation Rupture [0.03%]
一种可解释的基于血流动力学的机器学习模型的开发和验证，用于预测脑动静脉畸形破裂风险
Chengzhuo Wang,Tzak Sing Lau,Heze Han et al.
Chengzhuo Wang et al.
Cerebral arteriovenous malformation (AVM) is a cerebrovascular disease associated with a risk of intracranial hemorrhage. Currently, most risk prediction models for AVM rupture are based on demographic characteristics and lesion morphology,...
Multicenter Study
Translational stroke research. 2025 Dec 26;17(1):8. DOI:10.1007/s12975-025-01393-7 2025
Anticoagulation after Hemorrhagic Transformation in Acute Cardioembolic Ischemic Stroke [0.03%]
出血性转变的急性心源性缺血性卒中后的抗凝治疗
Hyunsoo Kim,Ye-Eun An,Beom-Seok Seo et al.
Hyunsoo Kim et al.
To assess the association of anticoagulation in patients with cardioembolic acute ischemic stroke (CES) who develop hemorrhagic transformation (HT) and its impact on neuroimaging and functional outcomes. This retrospective study enrolled pa...
Transcutaneous Auricular Vagus Nerve Stimulation Reduces Inflammatory Biomarkers after Large Vessel Occlusion Stroke: Results of a Prospective Randomized Open-Label Blinded Endpoint Trial [0.03%]
耳迷走神经刺激减少大型血管阻塞型卒中后的炎症标志物：一项前瞻性开放性盲终点试验的结果
Osvaldo J Laurido-Soto,Gansheng Tan,Susan Searles Nielsen et al.
Osvaldo J Laurido-Soto et al.
Inflammation exacerbates brain injury following acute ischemic stroke (AIS). Transcutaneous auricular vagus nerve stimulation (taVNS) reduces systemic inflammation, but its efficacy in AIS remains unexplored. We examined the safety and anti...
Randomized Controlled Trial
Translational stroke research. 2025 Dec 22;17(1):7. DOI:10.1007/s12975-025-01405-6 2025
Plasma Metabolites of Kynurenine Pathway and Risk of Stroke in the General Population: A Nested Case-control Study [0.03%]
普通人群血浆犬尿氨酸代谢物与卒中风险：一项队列病例对照研究
Yingjun Mu,Xudong Wang,Qingyao Wang et al.
Yingjun Mu et al.
Kynurenine pathway has been linked to several cardiovascular diseases, but their specific associations with stroke risk remain elusive. This study aimed to explore the associations between kynurenine pathway metabolites and the subsequent r...
Circadian Blood Pressure Phenotyping Identifies Subtype-Specific Risk and Outcomes in Acute Ischemic Stroke: A Prospective Study [0.03%]
急性缺血性卒中患者昼夜血压分型识别卒中铁板子风险及预后：前瞻性研究
Priyanka Boettger,Jamschid Sedighi,Michael Buerke et al.
Priyanka Boettger et al.
Circadian organization of blood pressure (BP) is increasingly recognized as a determinant of vascular risk, but its role in acute ischemic stroke (AIS) remains undefined. We investigated whether early circadian BP phenotypes derived from hi...