Integration of Multi-Omics and Machine Learning Identifies TGFB1 and SERPINE1 as Biomarkers of Vascular Smooth Muscle Cell Senescence in Intracranial Aneurysms [0.03%]
多组学和机器学习的整合鉴定出TGFB1和SERPINE1为颅内动脉瘤血管平滑肌细胞衰老的生物标志物
Haoran Qiu,Kai Chen,Yunruo Chen et al.
Haoran Qiu et al.
Intracranial aneurysms (IAs) are severe cerebrovascular disorders lacking effective gene therapy or pharmacological interventions. Vascular smooth muscle cell (VSMC) senescence has been associated with various cardiovascular and cerebrovasc...
Transplantation of Skin-Derived Precursor Schwann Cells Ameliorates Secondary Brain Injury after ICH in Mice by Activating the PI3K/AKT/FOXO3a Signaling Pathway [0.03%]
皮肤源性前体施万细胞通过激活PI3K/AKT/FOXO3a信号通路移植改善ICH小鼠 secondary brain injury
Yuqian Tang,Yan Song,Qiuwen Sun et al.
Yuqian Tang et al.
This study investigated the therapeutic potential of skin-derived precursor Schwann cells (SKP-SCs) for secondary brain injury following intracerebral hemorrhage (ICH) and its underlying mechanisms. An ICH model was established in mice via ...
Correction to: The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism [0.03%]
关于TP53ARG72PRO多态性决定神经元缺血耐受性的校正文章
Maria E Ramos-Araque,Cristina Rodriguez,Rebeca Vecino et al.
Maria E Ramos-Araque et al.
Published Erratum
Translational stroke research. 2026 Feb 3;17(1):22. DOI:10.1007/s12975-026-01417-w 2026
Identification of Brain Regions and Networks Critical to Poststroke Cognitive Impairment Through Lesion-symptom and Lesion Network Analyses [0.03%]
基于卒中病灶与认知功能损害关系及病灶连接子图的分析鉴别影响卒中后认知损害的关键脑网络
Min Li,Shijie Long,Mingxi Dang et al.
Min Li et al.
Clarifying the critical lesion regions of poststroke cognitive impairment (PSCI) could improve the understanding of how anatomical locations and functional networks jointly influence the manifestation of cognitive deficits. Lesion-symptom a...
Feasibility of a Multi-Laboratory Model of Middle Cerebral Artery Thromboembolic Stroke with Thrombolysis: TE-MCAo [0.03%]
多中心实验室中间 cerebral MCA 栓塞性卒中溶栓模型的可行性：TE-MCAo
Michelle Lin,Mozammel Bhuiyan,Carly McCurry et al.
Michelle Lin et al.
No single animal stroke model satisfies all needs of translational stroke investigation. While the nylon filament model is widely accepted in preclinical translational stroke research, thromboembolic models have more physiological relevance...
Janos Lückl,Monika Szücs,Ferenc Rarosi et al.
Janos Lückl et al.
A gap in developing novel preclinical treatment strategies for ischemic stroke is predicting long-term outcome in experimental stroke models early during ischemia to reduce heterogeneity and sample size. Besides saving costs through improve...
Outcomes of Bypass Surgery in Patients with Moyamoya Syndrome Secondary To Sickle Cell Disease: a Multicenter Study [0.03%]
关于镰形细胞病继发 moyamoya 综合征患者旁路手术效果的多中心研究
Basel Musmar,Joanna M Roy,Hammam Abdalrazeq et al.
Basel Musmar et al.
Background: Moyamoya syndrome (MMS) associated with sickle cell disease (SCD) is a severe vasculopathy that significantly increases stroke risk. While cerebral revascularization is increasingly considered in this populati...
Multicenter Study
Translational stroke research. 2026 Jan 21;17(1):18. DOI:10.1007/s12975-026-01412-1 2026
Recent Advances in Mitochondrial Transplantation for Ischemic Stroke: A Review of in Vitro and in Vivo Studies [0.03%]
缺血性卒中线粒体移植的最新进展：体内外研究综述
Zixian Mei,Weijie Zhong,Tanjun Deng et al.
Zixian Mei et al.
Ischemic stroke is a common and devastating disease that imposes a huge burden on global health and the economy. Mitochondrial dysfunction is a key feature of cerebral ischemia-reperfusion injury (CIRI). Mitochondrial transplantation, an em...
Collagen Imaging in Human Intracranial Aneurysms - a Translational Proof-of-Concept Study [0.03%]
人脑动脉瘤胶原成像的转化概念验证研究
Katharina A M Hackenberg,Nicola Willett,Uwe Seibold et al.
Katharina A M Hackenberg et al.
Unruptured intracranial aneurysms (IAs) are highly prevalent in the general population and there is an unmet need for radiological surrogates for the assessment of an increased risk of rupture. High turnover of type I collagen, i.e. abundan...
Association between Lipid Accumulation Product and 3-Month Functional Outcome after Ischemic Stroke: the Obesity-Stroke Paradox [0.03%]
脂质蓄积产物与缺血性卒中后3个月功能结局的相关性：肥胖性卒中的悖论
Yuan Ren,Ying Zhou,Tian-Yu Gu et al.
Yuan Ren et al.
To explore the association of lipid accumulation product (LAP) with 3-month functional outcome and etiologic subtypes in patients with acute ischemic stroke. Patients with acute ischemic stroke admitted from July 1, 2020, to June 30, 2022 w...