After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum [0.03%]
脑内出血后大鼠纹状体内少突前体细胞在白质纤维束内增殖分化
Michael J E Joseph,Jayalakshmi Caliaperumal,Lyanne C Schlichter
Michael J E Joseph
Damage to myelinated axons contributes to neurological deficits after acute CNS injury, including ischemic and hemorrhagic stroke. Potential treatments to promote re-myelination will require fully differentiated oligodendrocytes, but almost...
Nils Henninger,Marc Fisher
Nils Henninger
Pharmacological and device-induced reperfusion therapies have demonstrated increasingly positive outcomes regarding both reperfusion efficacy and 90-day functional outcomes after acute ischemic stroke. However, presently, only a minority of...
Transient Aortic Occlusion Augments Collateral Blood Flow and Reduces Mortality During Severe Ischemia due to Proximal Middle Cerebral Artery Occlusion [0.03%]
短暂性主动脉阻塞可增强严重大脑中动脉阻塞性缺血时的侧支循环及减少死亡率
Gomathi Ramakrishnan,Bin Dong,Kathryn G Todd et al.
Gomathi Ramakrishnan et al.
Cerebral collateral circulation provides alternative vascular routes for blood to reach ischemic tissues during stroke. Collateral therapeutics attempt to augment flow through these collateral channels to reduce ischemia and brain damage du...
Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man [0.03%]
棕榈乙醇胺/芹菜素在脑缺血治疗中的应用：从实验动物到人体研究
Carlo Caltagirone,Carlo Cisari,Carlo Schievano et al.
Carlo Caltagirone et al.
Acute ischemic stroke, the most frequent cause of permanent disability in adults worldwide, results from transient or permanent reduction in regional cerebral blood flow and involves oxidative stress and inflammation. Despite the success of...
Observational Study
Translational stroke research. 2016 Feb;7(1):54-69. DOI:10.1007/s12975-015-0440-8 2016
Acute Blockage of Notch Signaling by DAPT Induces Neuroprotection and Neurogenesis in the Neonatal Rat Brain After Stroke [0.03%]
组织蛋白酶S抑制剂AVP-013通过减少缺血性脑卒中后神经炎症和铁过载发挥神经保护作用
Zhongxia Li,Jiangping Wang,Congying Zhao et al.
Zhongxia Li et al.
Notch signaling is critically involved in various biological events. Notch undergoes cleavage by the γ-secretase enzyme to release Notch intracellular domain that will translocate into nucleus to result in expression of target gene. γ-Sec...
Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke [0.03%]
鬼笔环肽作为缺血性及出血性卒中的潜在治疗靶点
Qasim Alhadidi,Muhammad Shahdaat Bin Sayeed,Zahoor A Shah
Qasim Alhadidi
Neurovascular unit (NVU) is considered as a conceptual framework for investigating the mechanisms as well as developing therapeutic targets for ischemic and hemorrhagic stroke. From a molecular perspective, oxidative stress, excitotoxicity,...
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction [0.03%]
急性大脑中动脉脑梗死患者液体摄入与脑水肿的相关性研究
Pornpatr A Dharmasaroja
Pornpatr A Dharmasaroja
Evidence of the appropriate amount of fluid intake during the first few days after acute stroke was scarce. Concerns were raised in patients with acute malignant middle cerebral infarction, who tended to have malignant brain edema later. Th...
Post-Stroke Walking Behaviors Consistent with Altered Ground Reaction Force Direction Control Advise New Approaches to Research and Therapy [0.03%]
步态地面反作用力方向控制异常提示中风后步行行为的改变并为研究和康复治疗提出新建议
Wendy L Boehm,Kreg G Gruben
Wendy L Boehm
Recovery of walking after stroke requires an understanding of how motor control deficits lead to gait impairment. Traditional therapy focuses on removing specific observable gait behaviors that deviate from unimpaired walking; however, thos...
Matched Cohort Analysis of the Effects of Limb Remote Ischemic Conditioning in Patients with Aneurysmal Subarachnoid Hemorrhage [0.03%]
血管性亚急性期蛛网膜下腔出血患者远隔缺血适应效果的匹配队列研究
Azim N Laiwalla,Yinn Cher Ooi,Raymond Liou et al.
Azim N Laiwalla et al.
Remote ischemic conditioning (RIC) is a powerful innate response to transient subcritical ischemia that protects against severe ischemic insults at distant sites. We have previously shown the safety and feasibility of limb RIC in aneurysmal...
Controlled Clinical Trial
Translational stroke research. 2016 Feb;7(1):42-8. DOI:10.1007/s12975-015-0437-3 2016
Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion [0.03%]
部分MHC结构体治疗以早期免疫扩张为特征的血栓性缺血性脑卒中
Abby L Dotson,Yingxin Chen,Wenbin Zhu et al.
Abby L Dotson et al.
Inflammation and thrombosis are tightly linked, with inflammation contributing to thromboembolism and to stroke outcome. Thromboembolism is a frequent cause of ischemic stroke; yet, the most used occlusion mouse models of experimental strok...