ALOX5AP gene variants show differential association with coronary artery disease in different populations [0.03%]
ALOX5AP基因变异在不同人群中的冠状动脉疾病差异相关性研究
Ahmad Alwan,Sonia C Youhanna,Daniel E Platt et al.
Ahmad Alwan et al.
Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population studied. In this...
Breast and ovarian cancer risk evaluation in families with a disease-causing mutation in BRCA1/2 [0.03%]
BRCA1/2致病突变家庭的乳腺癌和卵巢癌风险评估
Elena Beristain,Berta Ibáñez,Itziar Vergara et al.
Elena Beristain et al.
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, and their identification allows genetic testing of at-risk relatives. However, estimates of these risks illustrate controversies, depending on the publish...
Developing and evaluating a culturally appropriate genetic service for consanguineous South Asian families [0.03%]
适合近亲婚配南亚族裔家庭的文化适宜型遗传学服务的建立与评估
Nasaim Khan,John Benson,Rhona Macleod et al.
Nasaim Khan et al.
Blackburn with Darwen Primary Care Trust (PCT) provides services to a substantial Asian population in which the practice of consanguineous marriage is common and there is a high incidence of autosomal recessive disorders. The aim was to pro...
Updating and refining a study brochure for a cancer registry-based study of BRCA mutations among young African American breast cancer patients: lessons learned [0.03%]
基于癌症登记处的BRCA突变研究的小册子更新与改进——年轻非裔美国乳腺癌患者的启示性经验
Susan T Vadaparampil,Tuya Pal
Susan T Vadaparampil
The aim of the present study was to update, refine, and evaluate a study brochure to promote participation in a population-based study of BRCA mutations among AA women with a personal history of early-onset breast cancer. A multi-step appro...
Genetic variants at the APOE, lipoprotein lipase (LpL), cholesteryl ester transfer protein (CETP), and endothelial nitric oxide (eNOS) genes and coronary artery disease (CAD): CETP Taq1 B2B2 associates with lower risk of CAD in Asian Indians [0.03%]
APOE、脂蛋白脂肪酶（LpL）、胆固醇酯转移蛋白（CETP）和内皮型一氧化氮合酶（eNOS）基因的遗传多态性与冠心病：CETP Taq1 B2B2 在印度人中与较低的冠心病发病风险相关
Aparna Amarendra Bhanushali,Bibhu R Das
Aparna Amarendra Bhanushali
Coronary artery disease (CAD) arises due to a complex interplay between the environment and genetic factors. Alterations in many of the biomarkers such as lipids and lipoprotein levels are characteristic of CAD. The phenotypes themselves ha...
Nadja Bogdanova,Arseni Markoff
Nadja Bogdanova
This review summarizes current knowledge about the role of hereditary hypercoagulation factors predisposing to thrombophilia-associated recurrent fetal loss. Thrombophilias are a major cause of adverse pregnancy outcome, playing a role in t...
Engaging African-Americans about biobanks and the return of research results [0.03%]
与非洲裔美国人讨论生物银行和研究结果的反馈问题
Colin Me Halverson,Lainie Friedman Ross
Colin Me Halverson
We conducted a deliberative engagement to assess attitudinal changes regarding biobank research, governance, and the return of results. We recruited African-Americans from two Southside Chicago health care facilities that serve communities ...
Using a "genomics tool" to develop disease prevention strategy in a low-income setting: lessons from the podoconiosis research project [0.03%]
利用基因组工具在低收入人群疾病预防策略中的应用——来自象皮肿研究的启示
Fasil Tekola Ayele,Adebowale Adeyemo,Charles N Rotimi
Fasil Tekola Ayele
Who is being referred to cancer genetic counseling? Characteristics of counselees and their referral [0.03%]
哪些人接受癌症遗传咨询？被咨询者的特征及其转诊情况
E van Riel,S van Dulmen,M G E M Ausems
E van Riel
Both physician and patient play a role in the referral process for cancer genetic counseling. Access to such counseling is not optimal because some eligible patients are not being reached by current referral practice. We aimed to identify f...
Maria Hedlund,Niclas Hagen,Ulf Kristoffersson
Maria Hedlund