In silico characterization of Shikimate Kinase of Shigella flexneri: a potential drug target [0.03%]
痢疾志贺菌希维醇激酶的计算机辅助表征：潜在的药物作用靶点研究
Neelima Arora,Amit Kumar Banerjee,U S N Murty
Neelima Arora
Shigella flexneri is a major pathogen responsible for Shigellosis causing massive morbidity among young population and imposes huge socio-economic burden. In this study, Shikimate Kinase (SK) from S. flexneri was characterized in silico and...
Deciphering role of amino acids for the stability of Staphylococcus aureus lipase (SAL3) [0.03%]
解析氨基酸对金黄色葡萄球菌酯酶(SAL3)稳定性的作用
Saravanan Parameswaran,Alpana Ankush Throat,Sanjukta Patra
Saravanan Parameswaran
Lipase from Staphylococcus aureus (SAL3) has been gaining attention because of its potential application in detergent industries against its thermostability and pH stability. It has been also used in synthesis of starch oleate recently. Pro...
Prediction of non-classical secreted proteins using informative physicochemical properties [0.03%]
基于具有判别能力的理化性质预测非经典分泌蛋白
Chiung-Hui Hung,Hui-Ling Huang,Kai-Ti Hsu et al.
Chiung-Hui Hung et al.
The prediction of non-classical secreted proteins is a significant problem for drug discovery and development of disease diagnosis. The characteristic of non-classical secreted proteins is they are leaderless proteins without signal peptide...
Effective 3D protein structure prediction with local adjustment genetic-annealing algorithm [0.03%]
基于局部调整遗传模拟退火算法的有效三维蛋白质结构预测方法
Xiao-Long Zhang,Xiao-Li Lin
Xiao-Long Zhang
The protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing the energy function. The protein folding structure prediction is computationally challenging and has been shown to ...
Computational identification and structural analysis of deleterious functional SNPs in MLL gene causing acute leukemia [0.03%]
计算识别并结构分析MLL基因的致病性功能SNP及其急性白血病发病原因
C George Priya Doss,R Rajasekaran,Rao Sethumadhavan
C George Priya Doss
A promising application of the huge amounts of data from the Human Genome Project currently available offers new opportunities for identifying the genetic predisposition and developing a better understanding of complex diseases such as canc...
Prediction of neurotoxins by support vector machine based on multiple feature vectors [0.03%]
基于多特征向量的支持向量机的神经毒素预测方法
Xuan-Min Guang,Yan-Zhi Guo,Xia Wang et al.
Xuan-Min Guang et al.
Neurotoxin is a toxin which acts on nerve cells by interacting with membrane proteins. Different neurotoxins have different functions and sources. With much more knowledge of neurotoxins it would be greatly helpful for the development of dr...
Codon populations in single-stranded whole human genome DNA Are fractal and fine-tuned by the Golden Ratio 1.618 [0.03%]
单链完整人类基因组DNA中密码子群体的分形特性及黄金比例1.618的优化作用
Jean-Claude Perez
Jean-Claude Perez
This new bioinformatics research bridges Genomics and Mathematics. We propose a universal "Fractal Genome Code Law": The frequency of each of the 64 codons across the entire human genome is controlled by the codon's position in the Universa...
Chemometrics-based approach to modeling quantitative composition-activity relationships for Radix Tinosporae [0.03%]
基于化学信息学的定量构效关系研究方法学构建及应用——菝葜干浸膏抗炎药效物质基础研究
Shi-Kai Yan,Zhong-Ying Lin,Wei-Xing Dai et al.
Shi-Kai Yan et al.
Quantitative composition-activity relationship (QCAR) study makes it possible to discover active components in traditional Chinese medicine (TCM) and to predict the integral bioactivity by its chemical composition. In the study, 28 samples ...
Exploiting graphics processing units for computational biology and bioinformatics [0.03%]
利用图形处理单元进行计算生物学和生物信息学研究
Joshua L Payne,Nicholas A Sinnott-Armstrong,Jason H Moore
Joshua L Payne
Advances in the video gaming industry have led to the production of low-cost, high-performance graphics processing units (GPUs) that possess more memory bandwidth and computational capability than central processing units (CPUs), the standa...
Evaluation of similarity measures for gene expression data and their correspondent combined measures [0.03%]
基因表达数据的相似性测度及其组合测度的评估
Gang-Guo Li,Zheng-Zhi Wang
Gang-Guo Li
It is commonly considered that genes with similar expression profiles are functional related. And there are many ways to measure the similarity of gene expression data. Especially with the advent of lots of biological information, new combi...