Wolfgang Sommer,Rainer Spanagel
Wolfgang Sommer
Sébastien Couillard-Després
Sébastien Couillard-Després
Although significant inconsistencies remain to be clarified, a role for neurogenesis in hippocampal functions, such as cognition, has been suggested by several reports. Yet, investigation in various species of mammals, including humans, rev...
Jeffrey H Meyer
Jeffrey H Meyer
Neurochemical imaging is frequently applied to measure markers of pathological change so as to understand mechanisms that create symptoms of major depressive disorder. For example, indices of greater monoamine oxidase A(MAO-A) level, partic...
Deficient plasticity in the hippocampus and the spiral of addiction: focus on adult neurogenesis [0.03%]
海马区成人神经发生的缺失与成瘾的恶性循环
Juan J Canales
Juan J Canales
Addiction is a complex neuropsychiatric disorder which causes disruption at multiple levels, including cognitive, emotional, and behavioral domains. Traditional biological theories of addiction have focused on the mesolimbic dopamine pathwa...
Network, cellular, and molecular mechanisms underlying long-term memory formation [0.03%]
长期记忆形成的神经元、细胞和分子机制
Mariana Carasatorre,Víctor Ramírez-Amaya
Mariana Carasatorre
The neural network stores information through activity-dependent synaptic plasticity that occurs in populations of neurons. Persistent forms of synaptic plasticity may account for long-term memory storage, and the most salient forms are the...
Adult-born neurons in the olfactory bulb: integration and functional consequences [0.03%]
嗅球新生神经元的整合及其功能影响
Gilles Gheusi,Gabriel Lepousez,Pierre-Marie Lledo
Gilles Gheusi
The generation of new neurons is sustained throughout life in the olfactory system. In recent years, tremendous progress has been made toward understanding the proliferation, differentiation, migration, and integration of newborn neurons in...
Neurogenesis in the adult mammalian brain: how much do we need, how much do we have? [0.03%]
成人哺乳动物脑神经发生：我们需要多少，我们拥有多少？
Ilias Kazanis
Ilias Kazanis
The last two decades cytogenic processes (both neurogenic and gliogenic) driven by neural stem cells surviving within the adult mammalian brain have been extensively investigated. It is now well established that within at least two cytogeni...
Phillip J Cowen
Phillip J Cowen
The classification of depression is well established in major diagnostic systems and operational definitions now make the diagnosis of depression reasonably reliable. However, classification and diagnosis continue to be based on clinical pr...
Jennifer Y F Lau
Jennifer Y F Lau
Rates of depression double in the transition to adolescence. Symptoms of depression in adolescence also predict adult mood disorders. From a preventative perspective, research into the risk factors for adolescent depression is critical. Sim...
Karen Hodgson,Peter McGuffin
Karen Hodgson
Since the publication of the working draft of the human genome just over a decade ago, there have been dramatic advances in our understanding of the role genetics play in both normal human functioning as well as in disease. The identificati...