Neural systems underlying reward and approach behaviors in childhood and adolescence [0.03%]
儿童及青少年时期奖赏和趋近行为的神经机制
Adriana Galván
Adriana Galván
Transitions into and out of adolescence are critical developmental periods of reward-seeking and approach behaviors. Converging evidence suggests that intriguing reward-related behavioral shifts are mediated by developmental changes in fron...
The role of corticolimbic circuitry in the development of anxiety disorders in children and adolescents [0.03%]
童年和青春期焦虑障碍的 corticolimbic 神经环路的作用机制研究
Johnna R Swartz,Christopher S Monk
Johnna R Swartz
Although most individuals progress through the periods of childhood and adolescence without significant disturbance, these developmental stages encompass the peak onset times for many forms of psychopathology related to altered emotion regu...
Connectivity [0.03%]
连通性
Francisco Xavier Castellanos,Samuele Cortese,Erika Proal
Francisco Xavier Castellanos
The connectivity of neuronal systems is their most fundamental characteristic. Here, we focus on recent developments in understanding structural and functional connectivity at the macroscale, which is accessible with current imaging technol...
Nina S Hsu,Susanne M Jaeggi
Nina S Hsu
Cognitive control, otherwise known as executive function, refers to our ability to flexibly adjust or regulate habitual actions or behaviors. As a cluster of separable components, it depends heavily on the prefrontal cortex, one of the last...
Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease [0.03%]
长跑而非氟西汀治疗可增加三转基因小鼠模型中阿尔茨海默病的神经发生，但不会改变其神经病理学特征
Michael W Marlatt,Michelle C Potter,Thomas A Bayer et al.
Michael W Marlatt et al.
Reductions in adult neurogenesis have been documented in the original 3xTg mouse model of Alzheimer's disease (AD), notably occurring at the same age when spatial memory deficits and amyloid plaque pathology appeared. As this suggested redu...
Randomized Controlled Trial
Current topics in behavioral neurosciences. 2013:15:313-40. DOI:10.1007/7854_2012_237 2013
Differential effects of stress and glucocorticoids on adult neurogenesis [0.03%]
应激和糖皮质激素对成人神经发生的不同影响
Timothy J Schoenfeld,Elizabeth Gould
Timothy J Schoenfeld
Stress is known to inhibit neuronal growth in the hippocampus. In addition to reducing the size and complexity of the dendritic tree, stress and elevated glucocorticoid levels are known to inhibit adult neurogenesis. Despite the negative ef...
Andrea Gómez-Palacio-Schjetnan,Martha L Escobar
Andrea Gómez-Palacio-Schjetnan
It has been suggested that long-term modifications of synaptic transmission constitute the foundation of the processes by which information is stored in the central nervous system. A group of proteins called neurotrophins are considered pow...
Katherine A Collins,Daniela Schiller
Katherine A Collins
The precise neural substrates of major depressive disorder (MDD) remain elusive, and FDA-approved antidepressants fail at least one-third of treatment-seeking patients. It is imperative, therefore, to identify novel research strategies to t...
Novel insights into depression and antidepressants: a synergy between synaptogenesis and neurogenesis? [0.03%]
抑郁症和抗抑郁药物的新见解：突触发生与神经发生之间的协同作用？
Francis Rodriguez Bambico,Catherine Belzung
Francis Rodriguez Bambico
Major depressive disorder has been associated with manifold pathophysiological changes. These include metabolic abnormalities in discreet brain areas; modifications in the level of stress hormones, neurotransmitters, and neurotrophic factor...
The effect of systemic chemotherapy on neurogenesis, plasticity and memory [0.03%]
系统化疗对神经发生、可塑性和记忆的影响
Peter Wigmore
Peter Wigmore
Chemotherapy has been enormously successful in treating many forms of cancer and improving patient survival rates. With the increasing numbers of survivors, a number of cognitive side effects have become apparent. These have been called "ch...