Nim Tottenham
Nim Tottenham
This chapter considers the functional utility of the prolonged period of immaturity in human brain development. Development of the amygdala and its connections with the prefrontal cortex is used as an example system for discussing the speci...
Anka D Mueller,Peter Meerlo,Dennis McGinty et al.
Anka D Mueller et al.
The hippocampal dentate gyrus plays a critical role in learning and memory throughout life, in part by the integration of adult-born neurons into existing circuits. Neurogenesis in the adult hippocampus is regulated by numerous environmenta...
Marguerite Matthews,Joel T Nigg,Damien A Fair
Marguerite Matthews
Over the last two decades, there have been numerous technical and methodological advances available to clinicians and researchers to better understand attention deficit hyperactivity disorder (ADHD) and its etiology. Despite the growing bod...
Sleep in childhood and adolescence: age-specific sleep characteristics, common sleep disturbances and associated difficulties [0.03%]
儿童和青少年的睡眠：年龄特异性睡眠特点、常见的睡眠障碍及相关的困扰
Nicola L Barclay,Alice M Gregory
Nicola L Barclay
Sleep changes throughout the lifespan, with particularly salient alterations occurring during the first few years of life, as well as during the transition from childhood to adolescence. Such changes are partly the result of brain maturatio...
Behavioral and electrophysiological correlates of sleep and sleep homeostasis [0.03%]
睡眠及睡眠稳态的行为学和电生理学特征
Tom Deboer
Tom Deboer
The definition of what sleep is depends on the method that is applied to record sleep. Behavioral and (electro)-physiological measures of sleep clearly overlap in mammals and birds , but it is often unclear how these two relate in other ver...
R J R Blair,Stuart F White,Harma Meffert et al.
R J R Blair et al.
The disruptive behavior disorders include Conduct Disorder (CD), Oppositional Defiant Disorder (ODD), and Attention Deficit Hyperactivity Disorder (ADHD). These disorders are highly comorbid with each other as well as with mood and anxiety ...
Xiao-Jiang Li,Shihua Li
Xiao-Jiang Li
Huntington's disease is caused by the expansion of a polyglutamine repeat (>37 glutamines) in the disease protein huntingtin, which results in preferential neuronal loss in distinct brain regions. Mutant huntingtin causes late-onset neurolo...
João Casaca Carreira,Ali Jahanshahi,Dagmar Zeef et al.
João Casaca Carreira et al.
Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: tra...
Tsung-Ung W Woo
Tsung-Ung W Woo
The clinical symptoms and cognitive and functional deficits of schizophrenia typically begin to gradually emerge during late adolescence and early adulthood. Recent findings suggest that disturbances of a specific subset of inhibitory neuro...
Rhia Ghosh,Sarah J Tabrizi
Rhia Ghosh
Huntington's disease (HD) is a devastating inherited neurodegenerative condition characterized by progressive motor, cognitive, and psychiatric symptoms. Symptoms progress over 15-20 years, and there are currently no disease-modifying thera...