Repair of the CNS using endogenous and transplanted neural stem cells [0.03%]
利用内源性和移植性的神经干细胞修复中枢神经系统
R C Trueman,A Klein,H S Lindgren et al.
R C Trueman et al.
Restoration of the damaged central nervous system is a vast challenge. However, there is a great need for research into this topic, due to the prevalence of central nervous system disorders and the devastating impact they have on people's l...
Kate E A Saunders,G M Goodwin
Kate E A Saunders
Patients with bipolar disorder more frequently suffer from depression than from mania. Indeed depressive symptomatology represents the majority of the illness burden experienced by bipolar patients and is also associated with elevated suici...
Margherita M Lee,Andreas Reif,Angelika G Schmitt
Margherita M Lee
Since its discovery in mammals, adult neurogenesis, the process of generating functional neurons from neural progenitor cells in the adult brain, has inspired numerous animal studies. These have revealed that adult neurogenesis is a highly ...
Christopher Barkus
Christopher Barkus
This chapter focuses on the use of genetically modified mice in investigating the neurobiology of depressive behaviour. First, the behavioural tests commonly used as a model of depressive-like behaviour in rodents are described. These tests...
Yan Gu,Stephen Janoschka,Shaoyu Ge
Yan Gu
Plasticity in the adult brain enables lifelong learning. The fundamental mechanism of adult neural plasticity is activity-dependent reorganization of pre-existing structure, in contrast to the widespread cellular proliferation and migration...
Jaanus Harro
Jaanus Harro
The rapid increase in the number of proposed animal models of depression reflects the dissatisfaction with our current state of knowledge on neurobiology of depression and unsuccessful drug development. Results obtained with even the best v...
Yasin Temel,Lee Wei Lim
Yasin Temel
The neurosurgical treatment of treatment-resistant depression (TRD) has entered a new era with more and more patients being treated with deep brain stimulation (DBS) via surgically implanted intracerebral electrodes. Although the mechanisms...
Trevor Sharp
Trevor Sharp
A long-standing theory is that brain monoamine signalling is critically involved in the mechanisms of antidepressant drug treatment. Theories on the nature of these mechanisms commenced with ideas developed in the 1960s that the drugs act s...
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis [0.03%]
关于跑步的一切：突触可塑性、生长因子和成人海马神经发生
Carmen Vivar,Michelle C Potter,Henriette van Praag
Carmen Vivar
Accumulating evidence from animal and human research shows exercise benefits learning and memory, which may reduce the risk of neurodegenerative diseases, and could delay age-related cognitive decline. Exercise-induced improvements in learn...
Effects of environmental enrichment exposure on synaptic transmission and plasticity in the hippocampus [0.03%]
环境丰富对海马突触传递和可塑性的影响
Michael J Eckert,Wickliffe C Abraham
Michael J Eckert
Exposure to an enriched environment (EE) is beneficial to the structure and function of the brain. The added sensory, social, and spatial complexity of the EE also improves cognitive functions such as memory in both healthy brains and damag...