Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [0.03%]
海马铁缺乏改变发育记忆系统之间的竞争与合作
Erik S Carlson,Stephanie J B Fretham,Erica Unger et al.
Erik S Carlson et al.
Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedur...
Molly Losh,Denise Esserman,Joseph Piven
Molly Losh
This study investigated rapid automatized naming (RAN) ability in high functioning individuals with autism and parents of individuals with autism. Findings revealed parallel patterns of performance in parents and individuals with autism, wh...
Common circuit defect of excitatory-inhibitory balance in mouse models of autism [0.03%]
自闭症小鼠模型中兴奋性-抑制性平衡的共同电路缺陷
Nadine Gogolla,Jocelyn J Leblanc,Kathleen B Quast et al.
Nadine Gogolla et al.
One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development. We examined whether Parvalbumin (PV)-positive in...
Kimberly Augenstein,Jane B Lane,Antony Horton et al.
Kimberly Augenstein et al.
We report a three generation family in which five members, three females and two males, demonstrate a 44 bp deletion (1164-1207del44) in the MECP2 gene associated with Rett syndrome, leading to a truncation of the C-terminus of the protein....
Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment [0.03%]
语言、言语和阅读测量的汇聚遗传连锁及家族关联性研究——以特定语言障碍患者家系为例
Mabel L Rice,Shelley D Smith,Javier Gayán
Mabel L Rice
We analyzed genetic linkage and association of measures of language, speech and reading phenotypes to candidate regions in a single set of families ascertained for SLI. Sib-pair and family-based analyses were carried out for candidate gene ...
Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism [0.03%]
脑源性神经营养因子和囊泡运输对树突棘发育与可塑性的调节作用及其在精神发育迟滞和孤独症等神经发育障碍中的重要作用
Christopher A Chapleau,Jennifer L Larimore,Anne Theibert et al.
Christopher A Chapleau et al.
The process of axonal and dendritic development establishes the synaptic circuitry of the central nervous system (CNS) and is the result of interactions between intrinsic molecular factors and the external environment. One growth factor tha...
Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse [0.03%]
罕见基因变异的建模以获得自闭症最古老生物标志物的研究见解：血清素转运体Gly56Ala敲入小鼠的构建
Jeremy Veenstra-Vanderweele,Tammy N Jessen,Brent J Thompson et al.
Jeremy Veenstra-Vanderweele et al.
Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attentio...
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons [0.03%]
Dlx1缺陷小鼠条件性恐惧反应下降及中间神经元亚型特异性丢失
Rong Mao,Damon T Page,Irina Merzlyak et al.
Rong Mao et al.
The inhibitory GABAergic system has been implicated in multiple neuropsychiatric diseases such as schizophrenia and autism. The Dlx homeobox transcription factor family is essential for development and function of GABAergic interneurons. Mi...
Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation [0.03%]
儿童自闭症患者听觉语言皮层磁共振研究中的右利优势现象
Nicole M Gage,Jenifer Juranek,Pauline A Filipek et al.
Nicole M Gage et al.
Purpose: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. ...
Alcino J Silva,Dan Ehninger
Alcino J Silva
Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatri...