Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment [0.03%]
语言、言语和阅读测量的汇聚遗传连锁及家族关联性研究——以特定语言障碍患者家系为例
Mabel L Rice,Shelley D Smith,Javier Gayán
Mabel L Rice
We analyzed genetic linkage and association of measures of language, speech and reading phenotypes to candidate regions in a single set of families ascertained for SLI. Sib-pair and family-based analyses were carried out for candidate gene ...
Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism [0.03%]
脑源性神经营养因子和囊泡运输对树突棘发育与可塑性的调节作用及其在精神发育迟滞和孤独症等神经发育障碍中的重要作用
Christopher A Chapleau,Jennifer L Larimore,Anne Theibert et al.
Christopher A Chapleau et al.
The process of axonal and dendritic development establishes the synaptic circuitry of the central nervous system (CNS) and is the result of interactions between intrinsic molecular factors and the external environment. One growth factor tha...
Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse [0.03%]
罕见基因变异的建模以获得自闭症最古老生物标志物的研究见解：血清素转运体Gly56Ala敲入小鼠的构建
Jeremy Veenstra-Vanderweele,Tammy N Jessen,Brent J Thompson et al.
Jeremy Veenstra-Vanderweele et al.
Alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-HT) production, storage and signaling have long been associated with autism. The 5-HT transporter gene (HTT, SERT, SLC6A4) has received considerable attentio...
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons [0.03%]
Dlx1缺陷小鼠条件性恐惧反应下降及中间神经元亚型特异性丢失
Rong Mao,Damon T Page,Irina Merzlyak et al.
Rong Mao et al.
The inhibitory GABAergic system has been implicated in multiple neuropsychiatric diseases such as schizophrenia and autism. The Dlx homeobox transcription factor family is essential for development and function of GABAergic interneurons. Mi...
Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation [0.03%]
儿童自闭症患者听觉语言皮层磁共振研究中的右利优势现象
Nicole M Gage,Jenifer Juranek,Pauline A Filipek et al.
Nicole M Gage et al.
Purpose: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. ...
Alcino J Silva,Dan Ehninger
Alcino J Silva
Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatri...