DNA methylation, the early-life social environment and behavioral disorders [0.03%]
生命早期的社会环境、表观遗传与行为障碍
Moshe Szyf
Moshe Szyf
One of the outstanding questions in behavioral disorders is untangling the complex relationship between nurture and nature. Although epidemiological data provide evidence that there is an interaction between genetics (nature) and the social...
Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders [0.03%]
智力障碍伴或不伴有刻板和自伤行为患者的应激轴及自主神经生物标志物 saliva中的研究
Frank J Symons,Jason J Wolff,Laura S Stone et al.
Frank J Symons et al.
Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intelle...
The benefit of directly comparing autism and schizophrenia for revealing mechanisms of social cognitive impairment [0.03%]
直接比较自闭症和精神分裂症以揭示社会认知缺陷机制的优势
Noah J Sasson,Amy E Pinkham,Kimberly L H Carpenter et al.
Noah J Sasson et al.
Autism and schizophrenia share a history of diagnostic conflation that was not definitively resolved until the publication of the DSM-III in 1980. Though now recognized as heterogeneous disorders with distinct developmental trajectories and...
Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterization [0.03%]
应用DSM-IV评估脆性X综合征患者的焦虑障碍：流行率和特点分析
Lisa Cordeiro,Elizabeth Ballinger,Randi Hagerman et al.
Lisa Cordeiro et al.
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability (ID). Anxiety and social withdrawal are considered core features of the FXS phenotype, yet there is limited diagnostic evidence of the prevalence of forma...
Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome [0.03%]
22q11.2缺失综合征患儿执行注意力网络的非典型发育特点研究
Joel Stoddard,Laurel Beckett,Tony J Simon
Joel Stoddard
Impairment in the executive control of attention has been found in youth with chromosome 22q11.2 deletion syndrome (22q11.2DS). However, how this impairment is modified by other factors, particularly age, is unknown. Forty-six typically dev...
How might stress contribute to increased risk for schizophrenia in children with chromosome 22q11.2 deletion syndrome? [0.03%]
应力如何导致22q11.2缺失综合征儿童患精神分裂症的风险增加？
Elliott A Beaton,Tony J Simon
Elliott A Beaton
The most common human microdeletion occurs at chromosome 22q11.2. The associated syndrome (22q11.2DS) has a complex and variable phenotype with a high risk of schizophrenia. While the role of stress in the etiopathology of schizophrenia has...
Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems [0.03%]
海马铁缺乏改变发育记忆系统之间的竞争与合作
Erik S Carlson,Stephanie J B Fretham,Erica Unger et al.
Erik S Carlson et al.
Iron deficiency (ID) is the most common gestational micronutrient deficiency in the world, targets the fetal hippocampus and striatum and results in long-term behavioral abnormalities. These structures primarily mediate spatial and procedur...
Molly Losh,Denise Esserman,Joseph Piven
Molly Losh
This study investigated rapid automatized naming (RAN) ability in high functioning individuals with autism and parents of individuals with autism. Findings revealed parallel patterns of performance in parents and individuals with autism, wh...
Common circuit defect of excitatory-inhibitory balance in mouse models of autism [0.03%]
自闭症小鼠模型中兴奋性-抑制性平衡的共同电路缺陷
Nadine Gogolla,Jocelyn J Leblanc,Kathleen B Quast et al.
Nadine Gogolla et al.
One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in the disruption of excitatory/inhibitory (E/I) circuit balance during critical periods of development. We examined whether Parvalbumin (PV)-positive in...
Kimberly Augenstein,Jane B Lane,Antony Horton et al.
Kimberly Augenstein et al.
We report a three generation family in which five members, three females and two males, demonstrate a 44 bp deletion (1164-1207del44) in the MECP2 gene associated with Rett syndrome, leading to a truncation of the C-terminus of the protein....