The effect of intellectual ability on functional activation in a neurodevelopmental disorder: preliminary evidence from multiple fMRI studies in Williams syndrome [0.03%]
分子影像遗传学在威廉斯综合征中的初步研究证据
Jennifer R Pryweller,Suzanne N Avery,Jennifer U Blackford et al.
Jennifer R Pryweller et al.
Background: Williams syndrome (WS) is a rare genetic disorder caused by the deletion of approximately 25 genes at 7q11.23 that involves mild to moderate intellectual disability (ID). When using functional magnetic resonan...
Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS) [0.03%]
脆性X综合征患儿儿童注意功能测验(KiTAP)的可行性、可靠性和临床有效性研究
Andrew Knox,Andrea Schneider,Floridette Abucayan et al.
Andrew Knox et al.
Background: Attention and inhibition are core executive-function deficits in FRagile X syndrome (FXS). This pilot study evaluated the feasibility, reproducibility, and clinical relevance of the KiTAP, a computer-based pic...
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings [0.03%]
精神病、神经发育障碍及遗传综合征的奖赏回路异常：动物模型和临床发现
Gabriel S Dichter,Cara A Damiano,John A Allen
Gabriel S Dichter
This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate d...
Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol [0.03%]
酒精早年暴露大鼠模型纹状体_parvalbaninin神经元的长期变化
Andrea De Giorgio,Sara E Comparini,Francesca Sangiuliano Intra et al.
Andrea De Giorgio et al.
Background: Exposure to alcohol in utero is a known cause of mental retardation. Although a certain degree of motor impairment is always associated with fetal alcohol spectrum disorder, little is known about the neurobiol...
Abnormal social reward processing in autism as indexed by pupillary responses to happy faces [0.03%]
自闭症患者对快乐面孔的瞳孔反应异常表明其社会奖励处理机制异常
Leigh Sepeta,Naotsugu Tsuchiya,Mari S Davies et al.
Leigh Sepeta et al.
Background: Individuals with Autism Spectrum Disorders (ASD) typically show impaired eye contact during social interactions. From a young age, they look less at faces than typically developing (TD) children and tend to av...
Preserved reward outcome processing in ASD as revealed by event-related potentials [0.03%]
自闭症患者事件相关电位与奖赏结果处理的关系
James C McPartland,Michael J Crowley,Danielle R Perszyk et al.
James C McPartland et al.
Background: Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-relat...
Association testing of copy number variants in schizophrenia and autism spectrum disorders [0.03%]
精神分裂症和自闭症谱系障碍中的拷贝数变异的关联分析
Bernard J Crespi,Helen J Crofts
Bernard J Crespi
Background: Autism spectrum disorders and schizophrenia have been associated with an overlapping set of copy number variant loci, but the nature and degree of overlap in copy number variants (deletions compared to duplica...
New approaches to investigating social gestures in autism spectrum disorder [0.03%]
自闭症谱系障碍中调查社会手势的新方法
Kenneth T Kishida,Jian Li,Justin Schwind et al.
Kenneth T Kishida et al.
The combination of economic games and human neuroimaging presents the possibility of using economic probes to identify biomarkers for quantitative features of healthy and diseased cognition. These probes span a range of important cognitive ...
Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions [0.03%]
自闭症谱系障碍成人做基于努力的决策时对奖励参数的变化缺乏敏感性
Cara R Damiano,Joseph Aloi,Michael Treadway et al.
Cara R Damiano et al.
Background: Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregul...
Response of neural reward regions to food cues in autism spectrum disorders [0.03%]
孤独症谱系障碍患者的奖赏脑区对食物线索的反应
Carissa J Cascio,Jennifer H Foss-Feig,Jessica L Heacock et al.
Carissa J Cascio et al.
Background: One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to social interaction and attachment. Prior research using established monetary rew...