TUNABLE COMPLEMENT ACTIVATION BY PARTICLES WITH VARIABLE SIZE AND Fc DENSITY [0.03%]
尺寸和Fc密度可调的颗粒引起补体激活的可调性
Patricia M Pacheco,Benjamin LE,David White et al.
Patricia M Pacheco et al.
The complement system is an integral innate immune component that is made up of a cascade of enzymatic proteins that, once activated, results in lysis of invading pathogens, opsonization or recruitment of other innate and/or acquired immune...
Amanda P Malefyt,S Patrick Walton,Christina Chan
Amanda P Malefyt
The development of nanoscale delivery vehicles for siRNAs is a current topic of considerable importance. However, little is understood about the exact trafficking mechanisms for siRNA-vehicle complexes across the plasma membrane and into th...
TARGETING OF MACROPHAGE FOAM CELLS IN ATHEROSCLEROTIC PLAQUE USING OLIGONUCLEOTIDE-FUNCTIONALIZED NANOPARTICLES [0.03%]
利用寡核苷酸功能化纳米颗粒靶向动脉粥样硬化斑块中的巨噬细胞泡沫细胞
Gaurav Sharma,Zhi-Gang She,David T Valenta et al.
Gaurav Sharma et al.
Macrophage foam cells are key components of atherosclerotic plaque and play an important role in the progression of atherosclerosis leading to plaque rupture and thrombosis. Foam cells are emerging as attractive targets for therapeutic inte...