Synthesis and Immunogenicity Assessment of Elastin-Like Polypeptide-M2e Construct as an Influenza Antigen [0.03%]
一种弹性蛋白多肽-M2e构建体的合成及其作为流感疫苗抗原的免疫原性评价研究
Rohan S Ingrole,Wenqian Tao,Jatindra N Tripathy et al.
Rohan S Ingrole et al.
The 23 amino acid-long extracellular domain of the influenza virus transmembrane protein M2 (M2e) has remained highly conserved since the 1918 pandemic, and is thus considered a good candidate for development of a universal influenza A vacc...
John N Barry,Alexey A Vertegel
John N Barry
There has been a significant amount of research done on liposomes and nanoparticles as drug carriers for protein drugs. Proteins and enzymes have been used both as targeting moieties and for their therapeutic potential. High specificity and...
Kevin Chung,Jessica A DeQUACH,Karen L Christman
Kevin Chung
Many studies have demonstrated that microscale changes to surface chemistry and topography affect cell adhesion, proliferation, differentiation, and gene expression. More recently, studies have begun to examine cell behavior interactions wi...
EFFECTS OF POLYMERIC NANOPARTICLE SURFACE PROPERTIES ON INTERACTION WITH BRAIN TUMOR ENVIRONMENT [0.03%]
聚合物纳米颗粒表面性质对其与脑肿瘤微环境相互作用的影响
Brandon Mattix,Thomas Moore,Olga Uvarov et al.
Brandon Mattix et al.
Current chemotherapy treatments are limited by poor drug solubility, rapid drug clearance and systemic side effects. Additionally, drug penetration into solid tumors is limited by physical diffusion barriers [e.g., extracellular matrix (ECM...
FEASIBILITY STUDY OF A CLINICAL BLOOD-BRAIN BARRIER OPENING ULTRASOUND SYSTEM [0.03%]
临床血液脑屏障开启超声系统的可行性研究
Fabrice Marquet,Yao-Sheng Tung,Elisa E Konofagou
Fabrice Marquet
In this paper, we investigate the focalization properties of single-element transducers at intermediate frequencies (500 kHz) through primate and human skulls. The study addresses the transcranial targeting involved in ultrasound-induced bl...
ANALYSIS OF DENDRITIC CELL STIMULATION UTILIZING A MULTI-FACETED NANOPOLYMER DELIVERY SYSTEM AND THE IMMUNE MODULATOR 1-METHYL TRYPTOPHAN [0.03%]
利用多面纳米聚合物递送系统及免疫调节剂N1-甲基色氨酸的树突状细胞刺激分析
Kevin P Nikitczuk,Edmund C Lattime,Rene S Schloss et al.
Kevin P Nikitczuk et al.
Dendritic cells (DCs) play a pivotal role in immune modulation. Therefore, understanding and regulating the mechanism of DC activation is paramount for functional optimization of any immunotherapy strategy. In particular, the paradoxical ab...
Andrew J Giustini,Alicia A Petryk,Shiraz M Cassim et al.
Andrew J Giustini et al.
The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with...
SENSING DNA WITH ALTERNATING CURRENTS USING A NANOGAP SENSOR EMBEDDED IN A NANOCHANNEL DEVICE [0.03%]
基于纳通道器件中纳米间隙传感器的交流电DNA检测法
Bret H Davis,Junhan Pan,Chih-Kuan Tung et al.
Bret H Davis et al.
We report an integrated nanochannel/nanoelectrode sensor for the detection of DNA using alternating currents. We find that DNA can be detected using platinum as the metal for the detecting electrodes, with a signal to noise ratio exceeding ...
PROBING α IIb β 3: LIGAND INTERACTIONS BY DYNAMIC FORCE SPECTROSCOPY AND SURFACE PLASMON RESONANCE [0.03%]
动态力光谱和表面等离子共振研究αIIbβ3受体与配体相互作用
Samrat Dutta,David A Horita,Roy R Hantgan et al.
Samrat Dutta et al.
The interaction between platelet integrin αIIbβ3 and fibrin(ogen) plays a key role in blood clot formation and stability. Integrin antagonists, a class of pharmaceuticals used to prevent and treat cardiovascular disease, are designed to c...
MICROFLUIDIC DEVICE FOR EXAMINING DIRECTIONAL SENSING IN DENDRITIC CELL CHEMOTAXIS [0.03%]
用于检测树突细胞化学趋向性中定向感应的微流控装置
Piyush Koria,Abhinav Bhushan,Daniel Irimia et al.
Piyush Koria et al.
Dendritic cell chemotaxis is an important process involved in the acquisition of adaptive immunity. Despite several studies, our understanding of this process remains limited. One of the reasons for this is the lack of experimental models t...