Hypoxia and Parkinson's Disease: A Dangerous Oversimplification Based on a Subpar Mouse Model [0.03%]
基于一个较差的小鼠模型的帕金森病与低氧的关系：危险的简单化理解
Martin Yarmush
Martin Yarmush
A recent Nature Neuroscience paper by Marutani and colleagues makes the striking claim that chronic hypoxia can reverse or even halt the progression of Parkinson's disease (PD), based on findings in an α-synuclein pre-formed fibril (PFF) m...
Chen-Hua Ma,Jeffrey Yang,Jenna L Mueller et al.
Chen-Hua Ma et al.
Photodynamic therapy (PDT) is a two-step procedure that involves the administration of special drugs, commonly called photosensitizers, followed by the application of certain wavelengths of light. The light activates these photosensitizers ...
REVERSAL OF FIBRONECTIN-INDUCED HIPPOCAMPAL DEGENERATION WITH ENCAPSULATED MESENCHYMAL STROMAL CELLS [0.03%]
骨髓间充质基质细胞通过封装逆转纤连蛋白诱导的海马退行性变
Jean-Pierre Dollé,Jeffrey Barminko,Sai Veruva et al.
Jean-Pierre Dollé et al.
Mesenchymal stromal cells (MSC) can promote tissue protection following injury, in part by modulating inflammatory cell responses. The aim of this study was to investigate the potential tissue protective properties of encapsulated MSCs (eMS...
Prostaglandin E2 Produced by Alginate-Encapsulated Mesenchymal Stromal Cells Modulates the Astrocyte Inflammatory Response [0.03%]
透明质酸包裹的间充质干细胞产生的前列腺素E2调节星形胶质细胞炎症反应
Elizabeth C Stucky,Joshua Erndt-Marino,Rene S Schloss et al.
Elizabeth C Stucky et al.
Astroglia are well known for their role in propagating secondary injury following brain trauma. Modulation of this injury cascade, including inflammation, is essential to repair and recovery. Mesenchymal stromal cells (MSCs) have been demon...
PRO-RESOLUTION POTENCY OF RESOLVINS D1, D2 AND E1 ON NEUTROPHIL MIGRATION AND IN DERMAL WOUND HEALING [0.03%]
Resolution类衍生物D1、D2和E1促进中性粒细胞迁移及真皮伤口愈合的作用研究
Riyesh Menon,Paulina Krzyszczyk,François Berthiaume
Riyesh Menon
An exuberant inflammatory response may exacerbate the primary tissue damage caused by injuries to the skin due to burns, surgery, excessive pressure, and other etiologies, thus increasing the time to heal. We hypothesized that application o...
Sizes and Sufficient Quantities of MSC Microspheres for Intrathecal Injection to Modulate Inflammation in Spinal Cord Injury [0.03%]
调控脊髓损伤后炎症的MSC微球载量及单次注射剂量上限研究
Suneel Kumar,Joanne Babiarz,Sayantani Basak et al.
Suneel Kumar et al.
Microencapsulation of mesenchymal stem cells (MSC) in alginate facilitates cell delivery, localization and survival, and modulates inflammation in vivo. However, we found that delivery of the widely used ~0.5 mm diameter encapsulated MSC (e...
Katsiaryna Kekalo,Fridon Shubitidze,Robert Meyers et al.
Katsiaryna Kekalo et al.
Magnetic nanoparticle hyperthermia uses magnetically-induced heat to kill cancer cells. In an alternating magnetic field, the induced heat depends strongly on particles' absorption properties. In order to achieve and maintain therapeutic te...
Alignment of Carbon Nanotubes: An Approach to Modulate Cell Orientation and Asymmetry [0.03%]
碳纳米管的排列：一种调节细胞取向和不对称性的方法
Qingsu Cheng,Greg M Harris,Marc-Olivier Blais et al.
Qingsu Cheng et al.
Stem cells offer a promising tool in tissue engineering strategies, as their differentiated derivatives can be used to reconstruct most biological tissues. These approaches rely on controlling the biophysical cues that tune the ultimate fat...
Magnetic Nanoparticles with High Specific Absorption Rate at Low Alternating Magnetic Field [0.03%]
低交变磁场下具有高比吸收率的磁性纳米颗粒
K Kekalo,I Baker,R Meyers et al.
K Kekalo et al.
This paper describes the synthesis and properties of a new type of magnetic nanoparticle (MNP) for use in the hyperthermia treatment of tumors. These particles consist of 2-4 nm crystals of gamma-Fe2O3 gathered in 20-40 nm aggregates with a...
Effect of Local Anesthetics on Human Mesenchymal Stromal Cell Secretion [0.03%]
局部麻醉药对人骨髓间充质干细胞分泌表型的影响
Andrea Gray,Ileana Marrero-Berrios,Mehdi Ghodbane et al.
Andrea Gray et al.
Anti-fibrotic and tissue regenerative mesenchymal stromal cell (MSC) properties are largely mediated by secreted cytokines and growth factors. MSCs are implanted to augment joint cartilage replacement and to treat diabetic ulcers and burn i...