Deep Immunophenotyping Reveals a Resilient Tph-ABC Axis in Difficult-to-treat Rheumatoid Arthritis: A Case Report of JAK Inhibitor Failure Complicated by Herpes Zoster and Thrombosis [0.03%]
深度免疫表型分析揭示了难治性类风湿关节炎中Tph-ABC轴的弹性：一种jak抑制剂失败并由带状疱疹和血栓并发症的病例报告
Chang-Lung Wu,Jeng-Wei Lu,Yi-Jung Ho et al.
Chang-Lung Wu et al.
Background/aim: The management of difficult-to-treat rheumatoid arthritis (D2T-RA) is frequently complicated by the occurrence of severe adverse events (SAEs) that severely restrict therapeutic options. Emerging evidence ...
Association of Liver Immune Status Index With the Nutritional Status and Prognosis in Patients With Cirrhosis [0.03%]
肝纤维化患者免疫指标与营养状况和预后的关系研究
Ryota Yoshioka,Takashi Nishimura,Naoto Ikeda et al.
Ryota Yoshioka et al.
Background/aim: In patients with cirrhosis, decreased immune function is observed and is considered to lead to various unfavorable clinical events. Although it is not easy to clinically evaluate the immune status of patie...
5-Azacytidine Enhances Differentiation of Human Placenta-derived Mesenchymal Stem Cells Towards Schwann-like Cells [0.03%]
5-氮杂胞苷增强人胎盘间充质干细胞向施万细胞样细胞的分化作用
Areechun Sotthibundhu,Wilasinee Promjantuek,Phongsakorn Kunhorm et al.
Areechun Sotthibundhu et al.
Background/aim: Mesenchymal stem cells (MSCs) can be used for regenerative medicine, particularly in the treatment of neurodegenerative diseases and peripheral nerve injuries. Among these, human placenta-derived mesenchym...
Refined Surgical Protocol for the Insertion of Bioactive-coated Titanium Microscrews in the Rat Tibia [0.03%]
改良的载生物活性物质微螺钉植入大鼠胫骨的外科操作流程
Alexis Vera-Becerra,Iván Valdivia-Gandur,Pablo Acuña-Mardones et al.
Alexis Vera-Becerra et al.
Background/aim: Sensitive bioactive coatings, such as polycaprolactone with cholecalciferol, present handling challenges in animal models due to their susceptibility to mechanical damage. This study aimed to develop and v...
Longitudinal Immune Profiling of T Cell Exhaustion During IL-17A Blockade in a Patient With HLA-B27-negative Spondyloarthritis and Sjögren's Syndrome: A Case Report [0.03%]
IL-17A抑制治疗HLA-B27阴性银屑病关节炎和舍格伦综合征患者的T细胞耗竭的纵向免疫特征分析：案例报告
Yu-Siang Su,Jeng-Wei Lu,Yi-Jung Ho et al.
Yu-Siang Su et al.
Background/aim: Coexisting Sjögren's syndrome (SS) and human leukocyte antigen-B27 (HLA-B27)-negative ankylosing spondylitis (AS) is rare and therapeutically challenging. In patients with prior Stevens-Johnson syndrome (...
Establishment of a Step-down FSH Superovulation Protocol in Microminipigs for Zygote Collection [0.03%]
微小型猪采卵用的递减FSH超数排卵方案的建立
Paing Thaw,Kazuki Hano,Ibuki Saito et al.
Paing Thaw et al.
Background/aim: Domestic pigs have become increasingly important models in translational research; however, their large size presents logistical and ethical challenges. Microminipigs offer a practical alternative for long...
Nutritional Assessment of Pesticide-associated Metabolic Stress in Plant-based Diets [0.03%]
植物性饮食中与农药相关的代谢压力的营养评估
Ramona Alina Tomuța,Maria Flavia Gîtea,Marc Cristian Ghitea et al.
Ramona Alina Tomuța et al.
Background/aim: Chronic low-dose pesticide exposure through high fruit and vegetable consumption is an underappreciated risk factor for metabolic dysfunction. While plant-based diets provide antioxidants and polyphenols, ...
Anti-Inflammatory and Anti-apoptotic Effects of Phosphodiesterase Inhibitors Against Streptozocin-induced Diabetic Nephropathy [0.03%]
磷酸二酯酶抑制剂对链尿佐菌素诱导的糖尿病肾病的抗炎和抗凋亡作用
Osama Mahmoud Mehanna,Basem H Elesawy,Ahmed Elaskary et al.
Osama Mahmoud Mehanna et al.
Background/aim: A variety of actions implicated in diabetic nephropathy (DN) are attributed to inflammatory cytokines and apoptosis of tubular epithelial cells. Building on our previous research demonstrating the role of ...
Dysregulation of ERAD and Stress Response Proteins by V493F FTO Over-expression: A Proteomic Perspective [0.03%]
V493FFTO过表达导致ERAD和应激反应蛋白失调：蛋白质组学视角
Aylin Kanli
Aylin Kanli
Background/aim: Demethylase fat mass and obesity-related protein (FTO), which belongs to the AlkB homologous (ABH) family, is associated with various neurological diseases, cancer, and obesity. This protein, which contain...