Oral Administration of Itraconazole Induces M1 Polarization of Tumor-associated Macrophages in Gynecological Cancer [0.03%]
口服伊曲康唑可诱导妇科肿瘤相关巨噬细胞向M1型极化
Tomoko Ueda,Hiroshi Tsubamoto,Roze Taniguchi et al.
Tomoko Ueda et al.
Background/aim: Itraconazole (ITZ), an antifungal agent with reported anticancer properties, has been shown to induce phenotypic repolarization of tumor-associated macrophages (TAMs) from an M2-like to an M1-like phenotyp...
Association Between AI-derived Thoracic Calcium Volume and Aortic Valve Calcification Quantified by Agatston Scoring [0.03%]
基于人工智能的冠脉钙化体积与升主动脉弓钙化程度的关系研究
Gonçalo G Almeida,Dana Belde,Mike Guldimann et al.
Gonçalo G Almeida et al.
Background/aim: Aortic valve calcification is a key determinant of aortic stenosis severity. Whether AI-derived thoracic aortic calcium volume reflects valvular calcification remains unclear. This study examined the assoc...
Stereotactic Radiotherapy for Metastatic Anaplastic Thyroid Cancer: A Single-center Experience and Systematic Review [0.03%]
立体定向放射治疗转移性间变性甲状腺癌的单中心经验及系统评价
Robert Rennollet,Ralph Gurtner,Claus Belka et al.
Robert Rennollet et al.
Background/aim: Anaplastic thyroid cancer (ATC) is a highly aggressive malignancy associated with a limited prognosis. Recent advances in targeted therapies and improved systemic therapy options have led to an increasing ...
Cost-Effectiveness of PSMA PET/CT as Single Procedure for Diagnosis and Staging High-Grade Prostate Cancer: A Single Center Experience [0.03%]
一次检查即可诊断和分期高危前列腺癌的PSMA-PET/CT性价比：单中心经验报告
Pietro Pepe,Ludovica Pepe,Gabriele Pepe et al.
Pietro Pepe et al.
Background/aim: Although prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is recommended for staging high risk prostate cancer (PCa), recently, it has demonstrated a good...
Male Sex as a Risk Factor for Perioperative Morbidity and Recurrence Following Minimally Invasive Distal Gastrectomy for Gastric Cancer: A Propensity Score Matching Analysis [0.03%]
胃癌微创远端胃大部切除术后围手术期并发症和复发的危险因素-倾向匹配分析
Yuma Ebihara,Noriaki Kyogoku,Hironobu Takano et al.
Yuma Ebihara et al.
Background/aim: This study aimed to investigate the effect of sex-related differences on surgical outcomes, postoperative complications, and prognosis in patients undergoing minimally invasive distal gastrectomy (MIDG) fo...
Protective Effect of Exercise Training Against Age-induced Cerebral Microvascular Rarefaction: VEGF/Flk-1/PI3K/Akt Signaling and GLUT1 Expression [0.03%]
运动训练防治脑微血管衰老的机制研究：VEGF/Flk-1/PI3K/Akt信号转导和葡萄糖转运体1表达的作用
Sheepsumon Viboolvorakul,Decha Buranajitpirom,Suthiluk Patumraj
Sheepsumon Viboolvorakul
Background/aim: Age-related cerebral microvascular loss is associated with reduced angiogenesis and leads to inadequate tissue perfusion in the brain. Vascular endothelial growth factor (VEGF), crucial for angiogenesis, d...
Ultra-low Concentrations of Cisplatinum Down to the IC10 in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells In Vitro and In Vivo [0.03%]
顺铂与低至IC10浓度的重组美登素联合使用可协同抑制肺癌细胞的体内和体外生长
Yohei Asano,Qinghong Han,Shukuan Li et al.
Yohei Asano et al.
Background/aim: To determine whether methionine restriction using recombinant methioninase (rMETase) enhances the efficacy of ultra-low-dose cisplatinum against lung cancer cells in vitro, and whether combining a methioni...
Onset and Outcomes of Immune-related Adverse Events in Genitourinary Cancer Treated With Immune Checkpoint Inhibitors [0.03%]
免疫检查点抑制剂治疗泌尿生殖系统肿瘤的免疫相关不良事件的发生及转归
Minoru Kato,Shoma Yamamoto,Taisuke Matsue et al.
Minoru Kato et al.
Background/aim: Immune checkpoint inhibitors are widely used in treating metastatic urothelial carcinoma and metastatic renal cell carcinoma. However, the incidence, timing, and clinical impact of immune-related adverse e...
Po-Yu Tsai,Tun-Shin Lo,Jing-Yang Huang et al.
Po-Yu Tsai et al.
Background/aim: Hypertension is a vascular disorder that affects both the vascular system and neural tissue. Insomnia may further impair health and contribute to dementia development. This study examined the association b...
Successful Retreatment of Chronic Hepatitis C Virus Genotype 1A Infection With Glecaprevir/Pibrentasvir in a Pediatric Patient With Developmental Disorder [0.03%]
一种发育障碍的儿童患者成功接受glecaprevir/pibrentasvir治疗慢性HCV 1a型感染
Toru Ishikawa,Koyata Fujii,Saeka Sakakibara et al.
Toru Ishikawa et al.
Background/aim: Although direct-acting antiviral (DAA) therapy is now available for pediatric patients with chronic hepatitis C virus (HCV) infection, the challenges associated with its use are similar to those observed i...