Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma [0.03%]
重组甲硫氨酰胺酶对野生型肉瘤细胞与阿霉素的协同作用强于正常细胞，并能克服高阿霉素耐药性肉瘤
Sei Morinaga,Qinghong Han,Kohei Mizuta et al.
Sei Morinaga et al.
Background/aim: Doxorubicin is first-line therapy for soft-tissue sarcoma, but patients can develop resistance which is usually fatal. As a novel therapeutic strategy, the present study aimed to determine the synergy of r...
Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score As a Predictor of Prognosis After Hepatectomy [0.03%]
血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分在肝切除术后的预后价值
Kazuaki Hashimoto,Hiroki Kanno,Hisamune Sakai et al.
Kazuaki Hashimoto et al.
Background/aim: The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is an immune-nutritional assessment score that is a prognostic indicator for several malignant tumors. This study aimed to investigate its pro...
Implications of TP-positive CAFs in the Bone Invasion of Oral Squamous Cell Carcinoma [0.03%]
阳性TP的癌症相关成纤维母细胞对口腔鳞状细胞癌骨侵犯的影响
Aihua Gao,Dong Wook Kim,Meiling Pei et al.
Aihua Gao et al.
Background/aim: Cancer-associated fibroblasts (CAFs) have recently been suggested as critical cellular components of bone invasion in oral squamous cell carcinoma (OSCC). However, the underlying molecular mechanisms and s...
The Novel Platinum Analog Dicycloplatin Provides Reliable Growth Inhibition of Urothelial Carcinoma Cells In Vitro [0.03%]
新型铂类药物二环铂体外抑制尿路上皮癌细胞增殖作用可靠
David Zekan,Thomas Hogan,Barbara Jackson et al.
David Zekan et al.
Background/aim: Platinum-based chemotherapies are a component of standard-of-care regimens for urothelial carcinoma (UC). These nephrotoxic drugs are often dose-limiting, with cisplatin and carboplatin being the most comm...
Corrigendum [0.03%]
勘误表
Published Erratum
Anticancer research. 2024 Jul;44(7):3221. DOI:10.21873/anticanres.17138 2024
Reduced Malignancy of Super Methotrexate-resistant Osteosarcoma Cells With Dihydrofolate Reductase Amplification Despite Paradoxical Gain of Oncogenic PI3K/AKT/mTOR and c-MYC expression [0.03%]
二氢叶酸还原酶扩增的超级甲氨蝶呤耐药性骨肉瘤细胞系的恶性程度降低，尽管出现了致癌性的PI3K / AKT / mTOR和c-MYC表达异常增强现象
Yusuke Aoki,Yutaro Kubota,Noriyuki Masaki et al.
Yusuke Aoki et al.
Background/aim: Methotrexate (MTX) resistance in osteosarcoma leads to a very poor prognosis. In the present study, in order to further understand the basis and ramifications of MTX resistance in osteosarcoma, we selected...
Sant P Chawla,Brian VAN Tine,Noah Federman et al.
Sant P Chawla et al.
A "Think Tank for Osteosarcoma" medical advisory board meeting was held in Santa Monica, CA, USA on February 2-3, 2024. The goal was to develop a strategic approach to prevent recurrence of osteosarcoma. Osteosarcoma metabolism and the geno...
PEMF Potentiates Doxorubicin-induced Late G2 Arrest in MDA-MB-231 Breast Cancer Cells [0.03%]
脉冲电磁场增强多西紫杉醇诱导的MDA-MB-231乳腺癌细胞晚期G₂停滞
Sung-Hun Woo,Byung Chul Jung,Jun-Young Kim et al.
Sung-Hun Woo et al.
Background/aim: Pulsed electromagnetic field (PEMF) stimulation enhances the efficacy of several anticancer drugs. Doxorubicin is an anticancer drug used to treat various types of cancer, including breast cancer. However,...
FLASH Effect Is Not Always Induced by Ultra-high Dose-rate Proton Irradiation Under Hypoxic Conditions [0.03%]
极低氧条件下极高剂量率质子照射不一定诱导闪光效应
Shinji Nomura,Masatoshi Hasegawa,Nagaaki Kamiguchi et al.
Shinji Nomura et al.
Background/aim: Pre-clinical studies have shown that irradiation with electrons at an ultra-high dose-rate (FLASH) spares normal tissue while maintaining tumor control. However, most in vitro experiments with protons have...
Combined Pubic Arch and Ischial Bone Resection for Metachronous and Frequent Local Recurrences of Rectal Cancer [0.03%]
联合耻骨和坐骨切除治疗直肠癌多发局部复发手术切除术式探讨
Koji Komori,Masahiro Yoshida,Satoshi Tsukushi et al.
Koji Komori et al.
Background/aim: Complete surgical resection with negative margins remains the cornerstone for curative treatment of rectal cancer; however, local recurrence can pose a significant challenge. Herein, we aimed to introduce ...