Prescription Medications and Overall Survival in Metastatic Hormone Sensitive Prostate Cancer [0.03%]
转移性激素敏感型前列腺癌的处方药与总体生存期的关系
Carley Pickett,Krishny Karunanandaa,Kaitlin Stackable et al.
Carley Pickett et al.
Background/aim: With new therapies for metastatic prostate cancer, patients are living longer, increasing the need for better understanding of the impact of comorbid disease. Prescription medications may risk-stratify pat...
Adipose-derived Mesenchymal Stem Cell Transplantation Improves Ovarian Function and Oocyte Quality in Aged Mice [0.03%]
脂肪来源的间充质干细胞移植改善老龄小鼠卵巢功能和卵子质量
Toyofumi Hirakawa,Fusanori Yotsumoto,Shiori Imi et al.
Toyofumi Hirakawa et al.
Background/aim: Age-related decline in the number of ovulations and ovum quality are major causes of female infertility, and stem cells have been reported to be effective in tissue regeneration. However, current therapeut...
Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer [0.03%]
野生型EGFR非小细胞肺癌术后复发免疫检查点抑制剂疗效分析
Yoshito Imamura,Taketo Kato,Yuji Nomata et al.
Yoshito Imamura et al.
Background/aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSC...
Inhibitory Effect of Pyra-Metho-Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments [0.03%]
Pyra-Metho-Carnitine对正常及肿瘤微环境巨噬细胞的分化和成熟具有抑制作用
Takanori Kitaguchi,Taichi Matsumoto,Kazumasa Yoshida et al.
Takanori Kitaguchi et al.
Background/aim: In a previous study, we have demonstrated heightened Pyra-Metho-Carnil (PMC) efficacy in nude mice with intact innate immunity that lack T and B cells. This has prompted hypothesizing that PMC may target m...
Identification of DNA Repair-related Genes as Biomarkers Reflecting MSI, TMB, and TIL in Colorectal Cancer [0.03%]
识别DNA修复相关基因作为反映微卫星不稳定性、肿瘤突变负荷和肿瘤浸润淋巴细胞的生物标志物在结直肠癌中的作用
Junya Fukuda,Tomoya Sudo,Maako Kikuchi et al.
Junya Fukuda et al.
Background/aim: There are no established biomarkers for immune checkpoint inhibitors (ICI) in colorectal cancer (CRC) with microsatellite stability (MSS) or proficient mismatch repair (pMMR). Therefore, this study aimed t...
Patient's HLA Genotype Is Associated With the Risk of Central Nervous System Dissemination and Clinical Disease Presentation in Diffuse Large B-cell Lymphoma [0.03%]
患者的人类白细胞抗原基因型与弥漫性大B细胞淋巴瘤中枢神经系统播散风险及临床疾病表现有关
Riina K Ollikainen,Antti Sippola,Taina Turpeenniemi-Hujanen et al.
Riina K Ollikainen et al.
Background/aim: Central nervous system (CNS) involvement in aggressive B-cell lymphoma, either as a primary or secondary event to systemic disease, portends a poor prognosis. This study sought to identify patients at high...
Evaluation of Interaction With Bio-absorbable Polyglycolic Acid Spacer and Anti-adhesive Agents Using a Rat Experimental Model [0.03%]
采用聚乙醇酸可吸收支架和防粘连剂的相互作用评价实验模型(大鼠)
Akihiro Fujisawa,Shohei Komatsu,Satoshi Omiya et al.
Akihiro Fujisawa et al.
Background/aim: Neskeep®, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed...
Influence of Tyrosine Kinase Inhibitors and Everolimus on TGFβ1 and TGF-β Receptor 2 in Squamous Cell Carcinoma Cells [0.03%]
酪氨酸激酶抑制剂和依维莫司对鳞状细胞癌中TGFβ1和TGF-β受体2的影响
Lena Huber,Manuel Thomas Knüttel,Benedikt Kramer et al.
Lena Huber et al.
Background/aim: Transforming growth factor-β (TGF-β) plays a significant role in the formation of different cancer subtypes. There is evidence that TGF-β pathways promote cancerogenic cell characteristics but also have...
Incorporating Tumor Genomic Profiling and Circulating Tumor Cell-derived Organoids into Clinical Practice for Gastrointestinal Cancers [0.03%]
肿瘤基因组学和循环肿瘤细胞衍生类器官在消化道癌症临床应用中的作用
Wen-Chi Wu,Chien-Fu Hsu,Ming-Huang Chen et al.
Wen-Chi Wu et al.
Background/aim: Precision medicine aims to revolutionize healthcare by tailoring treatment regimens. This study aimed to integrate comprehensive tumor genomic profiling (CTGP) by targeted-gene panel sequencing and drug sc...
Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes [0.03%]
肺癌脑转移瘤中三级淋巴器官结构的预后意义及其与临床结局的相关性
Shota Nohira,Shunichiro Kuramitsu,Masasuke Ohno et al.
Shota Nohira et al.
Background/aim: The prognosis of patients with brain metastases (BMs) originating from lung cancer remains poor, despite advancements in treatment strategies. The role of tertiary lymphoid structures (TLSs) within the tum...