Prognostic Impact of Early GNRI Sustainability in Metastatic Urothelial Carcinoma Receiving Pembrolizumab [0.03%]
早期GNRI持续性对接受帕博利尤单抗治疗的转移性尿路上皮癌患者预后影响的研究
Yosuke Sugiyama,Taku Naiki,Toshiharu Morikawa et al.
Yosuke Sugiyama et al.
Background/aim: To evaluate the prognostic significance of sustainability of the geriatric nutritional risk index (GNRI) in second-line chemotherapy in patients with metastatic urothelial carcinoma (mUC). ...
Adverse Events and Safety Outcomes Associated With Chemotherapy for Inflammatory Bowel Disease-associated Gastrointestinal Cancers [0.03%]
炎症性肠病相关胃肠道癌症化疗的不良事件和安全性结局
Noboru Hasegawa,Takayuki Ogino,Yuki Sekido et al.
Noboru Hasegawa et al.
Background/aim: Management of inflammatory bowel disease-associated gastrointestinal cancers, including Crohn's disease-associated cancer and ulcerative colitis-associated cancer, remains challenging because of concerns r...
Delayed Initiation of Postoperative S-1 Adjuvant Chemotherapy Worsens Prognosis After Gastric Cancer Recurrence [0.03%]
术后S-1辅助化疗延迟启动使胃癌复发预后恶化
Keiji Nishibeppu,Shinichi Sakuramoto,Yosuke Morimoto et al.
Keiji Nishibeppu et al.
Background/aim: Previous reports revealed the negative prognostic factors for patients with gastric cancer (GC) who received curative surgery plus postoperative S-1 chemotherapy. However, there were few reports on the sur...
Prognostic Impact of Lymph Node Ratio in Patients With Gastric Cancer Undergoing Curative Gastrectomy Post Neoadjuvant Chemotherapy [0.03%]
新辅助化疗后接受根治性胃切除术的胃癌患者的淋巴结比值预后价值
Keisuke Komori,Norihiro Akimoto,Yuta Nakayama et al.
Keisuke Komori et al.
Background/aim: The lymph node ratio (LNR), defined as the ratio of metastatic to examined lymph nodes, is a prognostic indicator in gastric cancer after curative gastrectomy. However, in response to neoadjuvant chemother...
Clinical Outcomes of the Optimized Weekly 8-Gy Palliative Radiotherapy Regimen [0.03%]
优化的 weekly 8 Gy 单独姑息放疗方案的临床疗效分析
Takeshi Fujisawa,Kenji Makita,Masaki Nakamura et al.
Takeshi Fujisawa et al.
Background/aim: At our institution, the "optimized weekly 8 regimen," administered as a single 8-Gy fraction once weekly for up to 3-4 fractions, is used for palliative radiotherapy. This study retrospectively evaluated t...
VEGF and Hypoxia Independently Induce MDR1 Expression to Promote Endothelial Cell Angiogenesis [0.03%]
缺氧和VEGF独立的诱导多药抗性蛋白表达以促进内皮细胞血管生成
Hyeong Sim Choi,Sung-Gook Cho,Min Kyoung Kim et al.
Hyeong Sim Choi et al.
Background/aim: Angiogenesis is a critical process in endothelial biology and tumor progression, primarily regulated by vascular endothelial growth factor (VEGF) and hypoxia. Multidrug resistance protein 1 (MDR1), best kn...
JI-CJ001 Enhances Paclitaxel Sensitivity in Gastric Cancer Cell Lines through Inhibition of HER2/mTOR Signaling and Induction of Autophagy [0.03%]
JI-CJ001通过抑制HER2/mTOR信号传导和诱导自噬增强紫杉醇对胃癌细胞系的敏感性
Min-Woo Kim,Sang-Eun Lee,So Eun Park et al.
Min-Woo Kim et al.
Background/aim: Addressing chemoresistance remains a significant challenge in cancer therapy. Human epidermal growth factor receptor 2 (HER2) signaling and autophagy are central mechanisms contributing to drug resistance ...
Real-world Comparative Study of Androgen Receptor Signaling Inhibitors in Japanese Patients With Non-metastatic Castration-resistant Prostate Cancer [0.03%]
日本非转移性去势抵抗性前列腺癌患者中雄激素受体信号抑制剂的现实世界比较研究
Masaaki Yanishi,Seiji Shimada,Takao Mishima et al.
Masaaki Yanishi et al.
Background/aim: Androgen receptor signaling inhibitors (ARSIs) are widely used for non-metastatic castration-resistant prostate cancer (nmCRPC). However, real-world data comparing clinical outcomes and treatment persisten...
Comparative Study
Anticancer research. 2026 Apr;46(4):2145-2151. DOI:10.21873/anticanres.18103 2026
Chemosensitizing Effects of Resveratrol Derivatives on p53-dependent Apoptosis Triggered by Cisplatin in Human Lung Cancer Cells [0.03%]
白藜芦醇衍生物诱导人肺癌细胞p53依赖性凋亡的化学增敏作用研究
Thanawut Pramualsin,Zin Zin Ei,Satapat Racha et al.
Thanawut Pramualsin et al.
Background/aim: Although cisplatin is a standard treatment for lung cancer, its effectiveness is often limited by tumor chemoresistance and severe side effects, driving the search for approaches that can restore drug sens...
Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells [0.03%]
茋类化合物的羟基甲醚和酮取代衍生物通过提高MEK/ERK结合亲和力增强其抗结直肠癌活性的研究
Pattharaporn Saelim,Zin Zin Ei,Satapat Racha et al.
Pattharaporn Saelim et al.
Background/aim: Colorectal cancer remains a major cause of cancer mortality, driven by recurrence, metastasis, and resistance to therapy. Resveratrol (Res) has notable anticancer properties, yet its clinical utility is li...