Targeted Sensitization of Leukemic T-cells to Anticancer Drugs by SIRT1 Agonist SRT-1720 [0.03%]
SIRT1激动剂SRT-1720增强白血病T细胞对化疗药物的敏感性
Donika Ivanova,Dessislava Lazarova,Zhivko Zhelev et al.
Donika Ivanova et al.
Background/aim: Leukemia therapy targets multiple molecular pathways, including non-oncogenic but clinically relevant factors such as Silent Information Regulator 1 (SIRT1), which acts either as a tumor suppressor or tumo...
Targeting mTOR Signaling in Cancer: The Promise of Natural Product-derived Inhibitors [0.03%]
靶向癌症mTOR信号：天然产物派生抑制剂的前景
Pithi Chanvorachote,Chatchai Chaotham,Zin Zin Ei et al.
Pithi Chanvorachote et al.
Recent advances in cancer biology have revolutionized the development of targeted and combination therapies, offering new avenues for improving cancer management. Among the central molecular regulators, the mammalian target of rapamycin (mT...
Anatomical-specific Lymphatic Route Beyond Mesorectal Fascia: Analyses from Female Cadavers and Patients With Rectal Cancer [0.03%]
女性尸体和直肠癌患者的解剖学特异性盆腔淋巴回流路径分布研究
Daisuke Kuwata,Hiroshi Shimoda,Takuya Miura et al.
Daisuke Kuwata et al.
Background/aim: This study aimed to clarify the lymphatic network around the anorectum using cadavers and consider a treatment strategy for locally advanced lower rectal cancer (LARC). ...
First-line FOLFOXIRI-based Chemotherapy for Unresectable Metastatic Colorectal Cancer: Real-world Outcomes, Safety, and Conversion Surgery [0.03%]
一线FOLFOXIRI为主的化疗用于不可切除的转移性结直肠癌：真实世界中的疗效、安全性及转化手术
Akira Inoue,Hirofumi Ota,Yusuke Matsuura et al.
Akira Inoue et al.
Background/aim: In Japan, contemporary real-world data that simultaneously assess effectiveness, safety, conversion feasibility, and long-term outcomes of first-line FOLFOXIRI-based chemotherapy for unresectable metastati...
Radiotherapy Strategies for Stage II Breast Cancer With Lymphovascular Invasion After Mastectomy [0.03%]
乳房切除术后淋巴血管侵袭性二期乳腺癌的放射治疗策略
Shuang Gao,Xueqiao Yu,Yang Li et al.
Shuang Gao et al.
Background/aim: Lymphovascular invasion (LVI) is a strong prognostic factor associated with poor survival outcomes in breast cancer. However, the clinical benefit of postmastectomy radiotherapy (PMRT) for early-stage dise...
Describing the Mutational Characteristics of Myxofibrosarcoma: An AACR Project GENIE Analysis [0.03%]
黏液纤维肉瘤的突变特征描述：AACR项目GENIE分析结果
Marlaena Nooney,Bryce Rigden,Elijah Torbenson et al.
Marlaena Nooney et al.
Background/aim: Myxofibrosarcomas (MFS) are highly infiltrative soft tissue sarcomas that most commonly occur in adults within the sixth to seventh decades. Diagnosis relies on histopathological analysis as no definitive ...
Clinical Parameters and Radiomics of Vestibular Schwannomas in NF2-related Schwannomatosis [0.03%]
NF2相关施万细胞瘤的前庭 schwannoma 的临床参数和影像组学特征
Nina Boe,Victor-F Mautner,Reinhard E Friedrich et al.
Nina Boe et al.
Background/aim: NF2-related schwannomatosis is a rare hereditary tumor predisposition syndrome, formerly known as Neurofibromatosis type 2 (NF2), and is characterized by the development of multiple schwannomas. The hallma...
Impact of the Immunonutritional Status on the Feasibility of Subsequent Treatment After the Discontinuation of Trifluridine-Tipiracil Plus Bevacizumab Therapy in Patients With Metastatic Colorectal Cancer [0.03%]
免疫营养状况对转移性结直肠癌患者 trifluridine-tipiracil 联合贝伐珠单抗治疗停药后后续治疗可行性的 影响
Yuki Seki,Masatsune Shibutani,Hideki Tanda et al.
Yuki Seki et al.
Background/aim: A smooth transition to subsequent treatments is crucial for improving the prognosis of patients with metastatic colorectal cancer who receive chemotherapy. This study aimed to examine how patient factors a...
Clinicopathological Significance of HER2 Expression Redefined by the HER2-low Concept in Ductal Carcinoma In Situ [0.03%]
HER2低表达概念下的导管原位癌的临床病理意义
Koji Takada,Shinichiro Kashiwagi,Mayuko Hirata et al.
Koji Takada et al.
Background/aim: The introduction of the HER2-low concept has redefined the biological spectrum of breast cancer. However, the clinicopathological and prognostic significance of HER2 expression in ductal carcinoma in situ ...
Tumor Location Significantly Correlates With PD-L1 Status in Patients With Small Sized Non-small Cell Lung Cancer [0.03%]
肿瘤位置与小细胞肺癌患者的PD-L1状态显著相关
Takuma Tsukioka,Ryu Nakajima,Kyukwang Chung et al.
Takuma Tsukioka et al.
Background/aim: Predicting programmed death-ligand 1 (PD-L1) expression in resectable lung cancer cases is highly significant for establishing treatment strategies. Although there were differences in tumor characteristics...