Teruya Uchiyama,Kunihiro Asanuma,Kouji Kita et al.
Teruya Uchiyama et al.
Background/aim: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, and lung metastasis is the major cause of death. Highly metastatic osteosarcoma cells are mechanically softer than ...
Prognostic Factors and the Impact of Adjuvant S-1 Chemotherapy in Resected Ampulla of Vater Carcinoma: A Single-institution Retrospective Study [0.03%]
壶腹癌手术的预后因素及辅助S-1化疗的影响：单中心回顾性研究
Hajime Imamura,Tomohiko Adachi,Takashi Hamada et al.
Hajime Imamura et al.
Background/aim: Ampulla of Vater carcinoma is a rare malignancy with limited survival after resection, and the role of adjuvant therapy remains unclear. S-1 (oral prodrug of 5-FU with modulators gimeracil and oteracil) ha...
Prognostic Factors for Pulmonary Metastasectomy for Colorectal Cancer: A Propensity Score Matching Analysis [0.03%]
结直肠癌肺转移手术的预后因素分析：倾向性评分匹配研究
Shoji Okado,Shota Nakamura,Minoru Sugihara et al.
Shoji Okado et al.
Background/aim: This study aimed to investigate prognostic factors in pulmonary metastasectomy for colorectal cancer (CRC), considering the location of the primary tumor. ...
Prolonged Castration Prior to Docetaxel Reduces Febrile Neutropenia in Patients With Metastatic Hormone-sensitive Prostate Cancer Receiving Triple Therapy [0.03%]
长效去势联合多西他赛可降低转移性雄激素敏感前列腺癌三联疗法患者的发热性中性粒细胞减少风险
Yasutaka Yamada,Tomoki Shirafuji,Kodai Sato et al.
Yasutaka Yamada et al.
Background/aim: Triplet therapy, combining androgen deprivation therapy (ADT), darolutamide, and docetaxel has recently emerged as the standard first-line treatment for metastatic hormone-sensitive prostate cancer (mHSPC)...
Splicing Factor SF3B4 Suppresses Pancreatic Cancer Growth and Migration by Inhibiting Autophagy [0.03%]
剪接因子SF3B4通过抑制自噬抑制胰腺癌的生长和迁移
So-Hyun Choi,Jiyoon Seo,Seung Min Jeong
So-Hyun Choi
Background/aim: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, characterized by aggressive progression, profound chemoresistance and unique metabolic adaptations such as elevated autophagy...
Differences of HER2 Status by HercepTest and PATHWAY 4B5 Immunohistochemical Assays in Breast Cancer [0.03%]
HercepTest和PATHWAY 4B5免疫组化在乳腺癌HER2状态检测中的差异分析
Shinsuke Sasada,Momoko Takaya,Kanako Suzuki et al.
Shinsuke Sasada et al.
Background/aim: Human epidermal growth factor receptor 2 (HER2) status assessment is subdivided according to trastuzumab-deruxtecan (T-DXd) suitability, and there is a discrepancy in HER2 staining depending on reagents. T...
POM121 Drives Gastric Cancer Progression via the mTOR/p70S6K Signaling Axis [0.03%]
POM121通过mTOR/p70S6K信号轴促进胃癌进展
Hong-Beum Kim,Seong-Hun Kim,Hye-Hwa Lee et al.
Hong-Beum Kim et al.
Background/aim: Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide. This study aimed to clarify the oncogenic function of POM121 and its involvement in signaling pathways driving t...
Alessia Nisco,Maria Tolomeo,Angela Sposato et al.
Alessia Nisco et al.
Background/aim: Uterine cancer is the fourth most frequently diagnosed cancer in women, and continues to present significant clinical challenges, particularly in older populations. Tumor progression is tightly linked to m...
Prognostic Significance of PPFIA2 in Localized Prostate Cancer: Integrative Analysis and Functional Validation [0.03%]
PPFIA2在局部前列腺癌中的预后价值：整合分析与功能验证
Jipu Liu,Cheng Ya Hsu,Jianming Lu et al.
Jipu Liu et al.
Background/aim: Prostate cancer (PCa) is a leading malignancy in men, with biochemical recurrence (BCR) indicating potential disease progression in up to 50% of patient's post-curative therapy. The liprin-α family gene P...
Prognostic Impact of Residual T and N Status After Neoadjuvant Therapy in Breast Cancer [0.03%]
新辅助治疗后乳腺癌患者残留淋巴结和原发灶病理状态的预后价值分析
Sae Fujioka,Shinichiro Kashiwagi,Yuko Kikukawa et al.
Sae Fujioka et al.
Background/aim: Residual disease after neoadjuvant systemic therapy (NST) is strongly associated with prognosis in breast cancer. However, currently available indices such as the Residual Cancer Burden (RCB) and Neo-Biosc...