Metabolism-driven Immune Escape Defines Therapeutic Vulnerability in Type I and Type II Ovarian Cancer [0.03%]
代谢驱动的免疫逃逸定义了一种治疗弱点，这种弱点在I型和II型卵巢癌中有所不同
Kohei Miyata,Fusanori Yotsumoto
Kohei Miyata
Ovarian cancer is a heterogeneous disease characterized by diverse molecular, metabolic, and immunological features, which contribute to limited and inconsistent responses to immunotherapy. Recent advances in cancer metabolism have revealed...
Metformin Induces PARP1-mediated Cell Death in NPC/HK1 Human Nasopharyngeal Carcinoma Cells [0.03%]
二甲双胍可通过PARP1介导的细胞死亡诱导鼻咽癌细胞凋亡
Chih-Chun Wang,Yaw-Chang Huang,Chief-Chung Wang et al.
Chih-Chun Wang et al.
Background/aim: Nasopharyngeal carcinoma (NPC) in endemic regions remains prone to treatment failure and poor prognosis due to distant metastasis, underscoring the need for novel therapeutic strategies. Metformin exhibits...
Identification of Risk Factors for the Local Recurrence of Hepatocellular Carcinoma Post-radiofrequency Ablation [0.03%]
射频消融后肝细胞癌局部复发危险因素的识别
Kosuke Tanaka,Akifumi Kuwano,Masayoshi Yada et al.
Kosuke Tanaka et al.
Background/aim: Radiofrequency ablation (RFA) is a mainstay curative treatment for unresectable hepatocellular carcinoma (HCC). Despite the success of RFA, however, some patients with HCC continue to experience local recu...
Ovarian Metastasis from EBV-Associated Undifferentiated Nasopharyngeal Carcinoma: An Exceptionally Rare Occurrence [0.03%]
EB病毒相关的未分化鼻咽癌卵巢转移：极其罕见的病例
Hatice Avsar,Imdat Eroglu,Aysenur Demirci et al.
Hatice Avsar et al.
Background/aim: Nasopharyngeal carcinoma (NPC) commonly metastasizes to bone, lung, and liver, whereas ovarian involvement is exceptionally rare, with only one previously reported case. Recognizing such atypical spread is...
Ubiquitin Ligase RNF149 Promotes Head and Neck Cancer Growth via Downregulation of CDKN2C [0.03%]
E3泛素连接酶RNF149通过下调CDKN2C促进头颈部肿瘤生长
Yu-Hsuan Hung,Min-Hong Wang,Li-Tzong Chen et al.
Yu-Hsuan Hung et al.
Background/aim: Head and neck squamous cell carcinoma (HNSC) remains one of the main causes of cancer-related deaths among male patients with cancer. Although surgery, chemotherapy, radiotherapy, targeted therapy, and imm...
IBP1 Represses the Migration and Invasion of Hepatocellular Carcinoma Cells by Inhibiting SOCE-dependent Formation of Neutrophil Extracellular Traps by Targeting the Akt Pathway [0.03%]
IBP1通过靶向Akt通路抑制SOCE依赖的中性粒细胞胞外陷阱形成从而抑制肝癌细胞迁移和侵袭
Yifeng Lou,N I Chen,Jiong Zheng et al.
Yifeng Lou et al.
Background/aim: Considering its implication in liver disease, we herein aimed to reveal the effects of Insulin-like growth factor-binding protein 1 (IBP1) in hepatocellular carcinoma (HCC). ...
Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models [0.03%]
胃癌前临床模型中PB101联合化疗的疗效研究
Minsung Park,Cheng Hyun Lee,Kui-Jin Kim et al.
Minsung Park et al.
Background/aim: Gastric cancer (GC) remains a leading cause of cancer-associated deaths globally, particularly in East Asia. Although anti-angiogenic therapies have yielded therapeutic benefit in GC, their efficacy is lim...
Chris D Platsoucas
Chris D Platsoucas
Imipramine Targets Apoptosis, Metastasis, and EGFR/SRC-mediated EMT in Oral Cancer Cells [0.03%]
伊米普利明靶向口腔癌细胞中的凋亡、转移及EGFR/SRC介导的上皮间质转化
Wei-Chun Wang,Ying-Tzu Chen,Fei-Ting Hsu et al.
Wei-Chun Wang et al.
Background/aim: Oral cancer (OC) exhibits aggressive growth and metastatic potential. Imipramine, a tricyclic antidepressant, has been recently explored for its anticancer activity. This study investigated imipramine's th...
Inhibition of AP-1 Reduces CD46-mediated Invasion of Bladder and Colon Cancer Cells [0.03%]
AP-1抑制减少膀胱癌和结肠癌细胞的CD46介导侵袭作用
Thuy Nguyen Thi,VAN-Tan Nguyen,Hien Duong Thanh et al.
Thuy Nguyen Thi et al.
Background/aim: CD46 is a membrane cofactor protein (MCP) essential for several physiological and pathological processes, including tumorigenesis and metastasis. In our previous studies, CD46 increased the production of m...