Leptomeningeal Metastasis in Patients With EGFR-positive NSCLC: A Propensity-matched Retrospective Study of Patients With EGFR-negative NSCLC [0.03%]
表皮生长因子受体阳性非小细胞肺癌患者脑膜转移的倾向匹配病例对照研究
Hiroaki Satoh,Kunihiko Miyazaki,Ryota Nakamura et al.
Hiroaki Satoh et al.
Background/aim: Although patients with epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) can expect long-term survival, some patients develop leptomeningeal metastasis (LM). The study aim...
HPV18-positive Small Cell Neuroendocrine Carcinoma of the Uterine Cervix Treated With Immunotherapy: A Case Report [0.03%]
人乳头瘤病毒18型阳性的子宫颈小细胞神经内分泌癌免疫治疗病例报告
Sakiko Masumoto,Masaaki Tanaka,Kenta Yamamoto et al.
Sakiko Masumoto et al.
Background: Small cell neuroendocrine carcinoma of the cervix (SCNEC) has an extremely poor prognosis. We report a case of recurrent SCNEC with CD274 [Programmed Death-Ligand 1 (PD-L1)] gene amplification and HPV18 positi...
Risk of Non-colorectal Malignancies in Sporadic Versus Lynch Syndrome-associated dMMR Colorectal Cancer [0.03%]
散发型与林奇综合征相关错配修复缺陷结直肠癌患者非结直肠恶性肿瘤风险的差异
Ioannis Gkekas,Jan Novotny,Tuomas Kaprio et al.
Ioannis Gkekas et al.
Background/aim: Deficient mismatch repair (dMMR) colorectal cancer (CRC) arises from either sporadic epigenetic changes or hereditary Lynch syndrome. This retrospective multicenter cohort study is the first to evaluate th...
Mechanistic Studies of Anticancer Effects of Salicylaldehyde Benzoylhydrazone in 2D/3D Lung Cancer Cell Cultures [0.03%]
基于二维和三维培养的肺癌细胞的水杨醛苯甲酰腙抗肿瘤作用机制研究
Wannapa Sangseekew,Jutatip Boonsombat,Sanit Thongnest et al.
Wannapa Sangseekew et al.
Background/aim: 3D culture models have become essential in cancer research, as they reflect tumor biology more accurately and predict in vivo responses more reliably. Numerous studies have proven that cells cultured in 3D...
EZH2 Expression Is Associated With Sensitivity to Inhibitors and Promotes Malignancy in Endometrial Cancer Cells [0.03%]
EZH2表达与子宫内膜癌细胞对抑制剂的敏感性相关并促进恶性肿瘤的发展
Takafumi Onishi,Hiroya Niimi,Aya Kumazaki et al.
Takafumi Onishi et al.
Background/aim: Endometrial cancer (EC) incidence is increasing globally, highlighting the need for novel therapies targeting molecular drivers of malignancy. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferas...
Severe Esophageal Ulceration With Enfortumab Vedotin Plus Pembrolizumab Therapy in Urothelial Carcinoma: A Case Report [0.03%]
恩Fortumab vedotin联合派姆单抗治疗尿路上皮癌致严重食管溃疡1例报告
Hiroki Bamba,Satoshi Yamamoto,Keita Higa et al.
Hiroki Bamba et al.
Background/aim: The combination of enfortumab vedotin (EV) and pembrolizumab (P) has been recently established as the standard first-line treatment for advanced urothelial carcinoma. While the safety profiles of individua...
Primary Debulking Surgery Versus Interval Debulking Surgery in the Management of Advanced-Stage Ovarian Cancer [0.03%]
卵巢癌初始减瘤术与间歇性减瘤术的比较研究
John P Micha,Randy D Bohart,Joshua P Gorman et al.
John P Micha et al.
Background/aim: The improved overall survival rates associated with advanced-stage ovarian cancer primarily reflect the surgeon's capacity to remove all residual disease following either primary debulking surgery (PDS) an...
CD133+ Lung Cancer Stem-like Cells Resist Plasma-activated Medium Through PRDX5-mediated Antioxidant Defense [0.03%]
CD133阳性肺癌类癌干细胞通过PRDX5介导的抗氧化防御抵抗等离子体活化介质
Nan-Nan Yu,Yue Liu,Xiao-Yu Guo et al.
Nan-Nan Yu et al.
Background/aim: Plasma-activated medium (PAM), which generates reactive oxygen and nitrogen species (RONS), has emerged as a promising anti-cancer approach. However, although PAM effectively eliminates bulk tumor cells, s...
Erlotinib Induces Cell Death by Blocking NIX-mediated Mitophagy Through Lysosomal Swelling in IDH1-mutant Cholangiocarcinoma [0.03%]
厄洛替尼通过溶酶体肿胀抑制NIX介导的线粒体自噬在IDH1突变胆管癌中诱导细胞死亡
Yonghyun Kang,Chorong Kim,Chan Yeop Jeong et al.
Yonghyun Kang et al.
Background/aim: Metabolic alterations resulting from mutation in tricarboxylic acid cycle enzymes such as isocitrate dehydrogenase 1 (IDH1) have been observed in various cancers. These alterations can be exploited as ther...
FAS/FAS-ligand Apoptotic Complex Deregulation in Laryngeal Squamous Cell Carcinomas [0.03%]
喉鳞癌中FAS/FAS-配体凋亡调控机制的失常
Michail Athanasopoulos,Vasileios Papanikolaou,Dimitrios Roukas et al.
Michail Athanasopoulos et al.
Background/aim: FAS/FAS-ligand (FAS-L) complex is implicated in critical cell functions including programmed cell death (apoptosis) and immune response regulation. FAS and FAS-ligand are members of the tumor necrosis fact...