Timing and Risk Factors for Hyperglycemia Associated With Anamorelin Administration [0.03%]
安非他明致高血糖的风险因素及发生时间
Yoshihiro Amakawa,Kazuo Kobayashi,Yuma Nonomiya et al.
Yoshihiro Amakawa et al.
Background/aim: Anamorelin, a ghrelin receptor agonist, alleviates cancer cachexia by stimulating appetite and growth hormone secretion but may induce hyperglycemia via insulin resistance. Although clinical trials have re...
Recurrence Risk Stratification in Clear Cell Renal Cell Carcinoma Using TNM 2017 and WHO/ISUP Grade [0.03%]
利用TNM(2017)和WHO/ISUP分级对透明细胞肾细胞癌复发风险进行分层
Kosuke Hamada,Takeshi Yamasaki,Chisato Ohe et al.
Kosuke Hamada et al.
Background/aim: To re-evaluate established recurrence risk models for clear cell renal cell carcinoma (ccRCC) using the tumor, node, metastasis (TNM) 2017 classification and the World Health Organization/International Soc...
Life-threatening Pneumonitis Induced by Osimertinib Monotherapy as a First-line Treatment for Epidermal Growth Factor Receptor Mutation-positive Non-small-cell Lung Cancer: A Retrospective Case-series Study [0.03%]
奥希替尼单药一线治疗表皮生长因子受体突变阳性非小细胞肺癌所致威胁生命的肺炎：一项病例系列研究
Takashi Nojiri,Akiisa Omura,Hiroshi Nishimura et al.
Takashi Nojiri et al.
Background/aim: Drug-related pneumonitis is a recognized adverse event associated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small-cell lung cancer (NSCLC). Osimertin...
Ovarian Sertoli Cell Tumor Coexisting With Uterine Malformation: A Case Report [0.03%]
与子宫畸形并存的卵巢塞托林细胞瘤一例报告
Oliwia Biegańska,Emilia Biczak,Grzegorz Przywara et al.
Oliwia Biegańska et al.
Background/aim: Ovarian Sertoli cell tumors (SCTs) are a rare subgroup of gonadal ovarian neoplasms. They typically occur in young patients and are usually benign. We present a case report of an elderly patient with uteri...
NK92-exo Induces Ferroptosis in A549 Cells by Targeting a miR-663a-SLC11A2 Axis [0.03%]
miR-663a-SLC11A2轴介导的NK92细胞外泌体诱导A549细胞铁死亡
Dong Lan,Liqiang Wei,Denghe Liu et al.
Dong Lan et al.
Background/aim: Natural killer (NK) cell-derived exosomes have demonstrated anti-cancer activity against various cancers, but the role in regulating ferroptosis in lung cancer remains unclear. This study investigates whet...
Inflammatory Cytokine Genotypic Markers and Ovarian Cancer Risk [0.03%]
炎症细胞因子基因多态性与卵巢癌发病风险关联的研究进展及展望
Wen-Shin Chang,Chia-Wen Tsai,Jaw-Chyun Chen et al.
Wen-Shin Chang et al.
Ovarian cancer is the most lethal gynecological malignancy worldwide, largely due to late diagnosis and lack of effective population-level screening tools. Inflammatory cytokines regulate proliferation, apoptosis, angiogenesis, and immune s...
Ascites: A Potential Diagnostic Surrogate for Genetic Profiling in Ovarian Cancer [0.03%]
卵巢癌基因分型的潜在诊断替代标志物——腹水检测
Estrid V Høgdall,Lau K Vestergaard,Douglas N P Oliveira et al.
Estrid V Høgdall et al.
Background/aim: Ovarian cancer is predominantly diagnosed in the late stages of the disease. Ascites can be collected before the start of neoadjuvant treatment or during the treatment course and may serve as a potential b...
Early Progressive Disease Predicts Poor Outcomes of Second-line VEGFR Tyrosine Kinase Inhibitor Therapy After First-line Nivolumab Plus Ipilimumab in Advanced Renal Cell Carcinoma [0.03%]
一线纳武利尤单抗联合伊匹木沙疗后早期疾病进展的晚期肾细胞癌患者二线使用VEGFR酪氨酸激酶抑制剂预后较差
Nobuki Furubayashi,Jiro Tsujita,Azusa Takayama et al.
Nobuki Furubayashi et al.
Background/aim: The optimal treatment sequence after first-line nivolumab plus ipilimumab (Nivo+Ipi) for advanced renal cell carcinoma remains unclear, particularly for patients with early progressive disease (PD). We eva...
Cytometry by Time-of-Flight for Profiling Therapeutic Response in Colorectal Cancer: Strengths, Limitations, and Translational Challenges [0.03%]
飞行时间质谱技术在结直肠癌治疗反应分析中的应用：优势、局限性及转化挑战
Eleandros Kyros,Adam Mylonakis,Pagona Kastanaki et al.
Eleandros Kyros et al.
Background/aim: Response assessment in colorectal cancer (CRC) still relies largely on anatomic imaging, which does not capture dynamic immune or stromal adaptation. Techniques like cytometry by time-of-flight (CyTOF) and...
Preoperative Cachexia Index Predicts Overall Survival Following Curative Resection for Remnant Gastric Cancer [0.03%]
术前恶病质指数可预测残胃癌根治术后生存期
Tomoyuki Matsunaga,Junpei Orihara,Tomohiro Takahashi et al.
Tomoyuki Matsunaga et al.
Background/aim: Remnant gastric cancer (RGC) remains a clinically challenging condition, and prognostic biomarkers reflecting host-related vulnerability are needed. The cachexia index (CXI), incorporating skeletal muscle ...